A.P. Pharma Inc., of Redwood City, Calif., will raise $4.5 million in convertible notes in a private placement deal with certain investors, including Tang Capital Partners...The discussion topics included dosing system, clarification of assays for manufacture and quality control, and a QT/metabolism clinical study

Under the agreement, GTC would receive an initial inventory of bulk drug substance for use in clinical studies...Merrimack's first major pharma deal, in 2009, focused on MM-121

The two companies share equally the cost of Phase II and Phase III clinical studies...ArQule's clinical pipeline additionally includes ARQ 621, an Eg5 inhibitor, in Phase I and ARQ 736, a pan-RAF inhibitor

Clinical studies are slated to start in early 2011

The Horizant NDA resubmission also included a final safety update, which provided updated and new safety information on patients in clinical studies who have been treated with the drug...Geron said it plans to use the net proceeds for R&D, including clinical trials for its product candidates, development activities for in-licensed products and other general corporate purposes

AstraZeneca plc, of London, and Bristol-Myers Squibb Co., of New York, reported results from a randomized, double blind Phase III clinical study demonstrating that the addition of the investigational drug dapagliflozin to existing therapy with glimepiride, a sulphonylurea, produced significant reductions of HbA1c levels, less than 7 percent, in adults with Type II diabetes vs...Sanofi and its partner, Zealand Pharma AS, of Copenhagen, Denmark, had reported top-line results in April

Clinical studies to date have shown a nasal formulation of a monovalent norovirus VLP vaccine to be immunogenic, having the ability to create an immune response, for example, and it is generally well tolerated

Bionomics Ltd., of Adelaide, Australia, released data that demonstrated efficacy of anti-anxiety compound BNC210 in preclinical and clinical studies...Bionor Pharma ASA, of Skein, Norway, reported that immune memory in HIV vaccination can be safely reactivated seven years after immunization with Vacc-4x, a peptide-based, therapeutic HIV vaccine, by re-vaccinating with Vacc-4x

Cerulean Pharma Inc., of Cambridge, Mass., reported results of a Phase I clinical study of CRLX101 (formerly IT-101), Cerulean's lead clinical development candidate, and preclinical data on Cerulean's development candidate, CRLX288, at the American Chemical Society National Meeting & Exposition, ongoing in Boston

Proceeds will be used for manufacture and clinical studies of its cancer therapeutic AEOL 10150, as well as preclinical development of other Aeolus compounds...Bioniche Pharma's lead product Urocidin for bladder cancer is currently in clinical trials. (See BioWorld Today, July 16, 2010.)

Going forward, Dicerna will use the $25 million Series B financing to support clinical studies of its oncology therapeutics, and will rely on further nondilutive funding from pharma partners to develop and mature its technology

Antisense Pharma GmbH, of Regensburg, Germany, said the FDA issued an investigational new drug authorization for clinical studies with the transforming growth factor-beta 2 inhibitor trabedersen for patients with high-grade glioma

The proceeds from the transaction will be used for further development of the company's lead clinical programs, including its Phase II clinical study program of Serdaxin, Zoraxel and Archexin

Horizon Pharma Inc., of Northbrook, Ill., reported interim results from a pilot clinical study showing that Lodotra (modified-release prednisone tablet) chronotherapy might improve asthma control and asthma-related quality of life when added to standard asthma therapy in patients with severe nocturnal asthma

KaloBios Pharmaceuticals Inc., of South San Francisco, said data from the initial clinical studies of KB001, an antibody fragment against PcrV on Pseudomonas aeruginosa, demonstrated promising therapeutic activity in the prevention of serious lung infection in mechanically ventilated patients colonized with the bacterium and in limiting potentially damaging inflammation in patients with cystic fibrosis

A Phase Ib study is planned at the established maximum-tolerated dose of 275 mg/m2 at various dosing schedules and in select tumor types including gastric, head and neck, breast and liver cancers, to seek additional signals of activity and to help guide future clinical studies...Noxxon Pharma AG, of Berlin, said it has successfully completed a Phase I trial with Spiegelmer NOX-A12, which is being developed for acute as well as chronic indications in the area of hematological malignancies and/or

Icagen Inc., of Research Triangle Park, N.C., said that based on the efficacy demonstrated in the firm's recent study of photosensitive epilepsy patients, coupled with a favorable clinical safety profile, consistent pharmacokinetics and the lack of a maximal tolerated dose in all clinical studies to date, the firm proposed, and the FDA has approved, a study of up to two additional cohorts of photosensitive epilepsy patients at higher doses of ICA-105665...Icagen said it currently expects that the

We have established collaborations with two big pharma companies on that," Soula said...The company said that funding will allow it to accelerate global launch of lead product ViaMetrics-E, a rapid, noninvasive procedure designed to enhance in vitro fertilization outcomes, as well as to complete an ongoing FDA clinical study and implement manufacturing and product enhancements

AM-Pharma BV, of Bunnik, the Netherlands, reported positive results from its Phase II acute kidney injury trial with alkaline phosphatase, which showed statistically significant improvement on the primary clinical endpoint and on several secondary endpoints after interim analysis of the treatment effect on 26 patients...This is the fifth clinical study to be initiated on STA-9090, a synthetic, small molecule Hsp90 inhibitor with a novel chemical structure