A.P. Pharma Inc., of Redwood City, Calif., filed a registration statement for a proposed public offering of up to $28.8 million in common stock...Proceeds from the financing are expected to support clinical development of APF530, a Phase III-stage drug for chemotherapy-induced nausea and vomiting, as well as for development of other drug candidates, working capital, capital expenditures and other general corporate purposes

Astellas Pharma, of Tokyo, and Theravance Inc., of South San Francisco, presented data from two Phase III trials in which telavancin compared favorably to standard therapy in the treatment of patients with complicated skin and skin structure infections, including those caused by Gram-positive organisms...The data were presented at the 17th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) in Munch. (See BioWorld Today, Dec. 11, 2006

Enzon licensed EZN-2968 in July from Santaris Pharma AS, of Horsholm, Denmark...The randomized, double-blind, placebo-controlled trial will enroll about 330 participants who will receive the drug twice a day for eight weeks and will measure changes in the Hamilton Anxiety Score, the Clinical Global Impressions Improvement Scale and the Clinical Global Severity of Illness Scale

Clinical Data Inc., of Newton, Mass., said its PGxHealth Division completed enrollment in a pivotal Phase III study of Vilazodone for the treatment of depression...The study was designed to supplement the European clinical trial database generated by Bayer Schering Pharma AG, of Berlin, which licensed U.S

Intarcia has conducted two Phase II clinical trials with an injectible formulation of omega interferon, both as a monotherapy and in combination with ribavirin...In prostate cancer, Bayer Schering Pharma AG markets the FDA-approved, CMS-reimbursed Viadur (leuprolide acetate implant...Last week, Memory started a Phase IIa clinical trial of MEM 3454 in Alzheimer's disease

Sucampo Pharma Ltd., of Tokyo, a subsidiary of Bethesda, Md.-based Sucampo Pharmaceuticals Inc., has begun a repeated-dose Phase I clinical study in Japan of Amitiza (lubiprostone), its U.S.-approved drug for chronic idiopathic constipation in adults...Clinical endpoints are regression and disappearance of lesions, safety and quality of life

7TM Pharma A/S, of Horsholm, Denmark, began a Phase I/II trial of TM30339, an obesity agent derived from the company's discovery program on Y4 receptor selective agonists...The primary clinical endpoint is the cumulative number of new gadolinium-enhancing lesions, a marker of MS disease activity...Secondary objectives include additional MRI measurements, analysis of clinical relapses, measures of neurologic disability, immunologic evaluations and safety

raised C$24.4 million (US$20.7 million) in a Series B round of financing, largely to advance its two lead pain programs into clinical development...Early in the programs' human testing, healthy volunteers would be used for establishing clinical efficacy through established models of pain "that are fairly predictive," Lamontagne said, "so you can get an idea of your compounds' efficacy, or some preliminary ideas...The transaction also includes options to purchase the number of preferred shares bought

Dermagraft clinical development goes back at least to the early 1990s, when Marrow-Tech Inc. - which soon after changed its named to Advanced Tissue Sciences Inc. - was conducting early testing of the dermal skin replacement product in indications including burns, chronic venous skin ulcers and diabetic ulcers...Antares Pharma Inc., of Ewing, N.J., closed on a secured credit facility consisting of two term loans that together total $10 million...Clinical Data Inc., of Newton, Mass., said it raised

of Tarrytown, N.Y., announced today that Novartis Pharma AG, of Basel, Switzerland, and its development partner Nordic Bioscience, of Herlev, Denmark, have initiated a Phase III trial of an oral form of salmon calcitonin, a new drug candidate that uses Emisphere's eligen-delivery technology to treat osteoporosis...In 2000, Emisphere and Novartis Pharma entered into a license agreement for the development of oral salmon calcitonin...The clinical trial is being conducted by Nordic Bioscience following a

The trial will enroll approximately 30 patients at one or two clinical sites in New Zealand...Adherex expects the financing to last into 2008 and support clinical development of cancer drugs ADH-1 (Exherin) and eniluracil, which was licensed from GlaxoSmithKline plc., of London. (See BioWorld Today, Jan. 19, 2007...IDM Pharma Inc., of Irvine, Calif., closed a $12.8 million private placement through the sale of 4.5 million shares of common stock at the market price of $2.82 per share

Cyclacel Pharmaceuticals Inc., of Berkeley Heights, N.J., said it plans to begin clinical development of seliciclib, an orally available cyclin dependent kinase inhibitor, in patients with nasopharyngeal cancer (NPC) in the second half of this year...That decision was based on clinical data from an independent investigator-sponsored study, in which antitumor activity was observed in seven out of 13 locally advanced, treatment-na ve NPC patients at a well tolerated dose...Scolr Pharma Inc., of Bellevue

Data were presented at the American Society of Clinical Oncology 2007 Gastrointestinal Cancers Symposium held in Orlando, Fla...Droxidopa, on the market since 1989 in Japan, was licensed from Dainippon Sumitomo Pharma Co...Data were presented at the American Society of Clinical Oncology Gastrointestinal Cancers Symposium in Orlando, Fla

The company said it will no longer pursue clinical development of that drug...MGI Pharma Inc., of Minneapolis, said data from a Phase III trial of Saforis (glutamine powder in UpTec) for Oral Suspension indicate that the drug significantly reduced the incidence of severe oral mucositis when compared to placebo

Staff Writer Preparing for upcoming clinical trials in secondary hyperparathyroidism and vitamin D deficiency in chronic kidney disease, Cytochroma Inc...EyeGate Pharma Inc., of Paris, closed a $2 million extension of its Series B round, bringing the total financing round to $12 million...Shares of Isis (NASDAQ:ISIS) lost 83 cents Wednesday to close at $11.25.

Commonly known as tetrahydrobiopterin, 6R-BH4 is an essential enzyme cofactor that is involved in the production of nitric oxide, a molecule that has been shown in clinical studies to play a key role throughout the cardiovascular system, including regulation of endothelial function...Enzon licensed the product from Santaris Pharma A/S, of Copenhagen, Denmark, in July 2006, along with a survivin antagonist and six additional RNA antagonist candidates, all directed at cancer targets. (See BioWorld

The revised clinical development plan also includes a Phase II study to evaluate CPP-109 in methamphetamine addition...MGI Pharma Inc., of Minneapolis, said results from its Phase II study evaluating three low dose regimens of Dacogen (decitabine) for injection in myelodysplastic syndromes and chronic myelomonocytic leukemia showed a 73 percent objective response rate, which included a 34 percent complete response rate, a 1 percent partial response rate, a 24 percent marrow complete response rate

A.P. Pharma Inc., of Redwood City, Calif., said it probably would not meet a previously announced target of a 2007 filing of its new drug application for APF530, due to a slower-than-expected rate of sites being activated in the ongoing 1,350-patient Phase III trial...Previously reported clinical trial results have shown 100 percent seroprotection after two doses in subjects 18 to 39 years of age, and after three doses in subjects 40 to 70...Nastech plans to advance its clinical obesity program in

ChemoCentryx Inc., of Mountain View, Calif., presented clinical and preclinical data from studies of the company's drug candidate Traficet-EN (CCX282-B), a first-in-class, orally active, anti-inflammatory agent that targets the chemokine receptor known as CCR9, at the 2006 Crohn's and Colitis Foundation of America's National Research and Clinical Conference/Fifth Annual Advances in the Inflammatory Bowel Diseases meeting being held this week in Miami...Schwarz Pharma AG, of Monheim, Germany