Proceeds will be used to support clinical trials with Amplimexon, a formulation of imexon for injection in oncology indications...Proceeds from the financings will be used to expand manufacturing capabilities and fund clinical trials, including ongoing Phase III trials with the Technosphere Insulin System...TopoTarget markets Savene for the treatment of anthracycline extravasation, the leakage of chemotherapeutics into surrounding tissue, and has seven oncology drugs in clinical development

pulled in a $30 million Series C financing to continue clinical development of obesity drugs Contrave and Excalia...presented preclinical data revealing an additive and synergistic weight loss effect when amylin is used in combination with other neurohormones and kicked off four clinical trials to evaluate the amylin analogue pramlintide in combination with leptin, PYY 3-36, the combination of leptin and PYY 3-36, and approved oral anti-obesity drugs...Anesiva expects to file a common technical

Proceeds from the current round should be sufficient to get there, and a clinical trial with ICS-283 is slated to begin before the end of 2007...Despite the significant interest both pharma and biotech have shown in the field, Azab said Intradigm plans to take ICS-283 through proof of concept without a partner...The trial will be conducted in Sweden and was green-lighted by Swedish regulatory authorities last month.

Aradigm Corp., of Hayward, Calif., said results of a Phase IIa trial of inhaled hydroxychloroquine (HCQ) in patients with moderate-persistent asthma did not meet the pre-specified clinical efficacy endpoints...MGI Pharma Inc., of Minneapolis, said interim results from 35 patients in its Phase II combination study of Gliadel Wafer (polifeprosan 20 with carmustine implant) in newly diagnosed, resectable, high-grade malignant glioma showed a median survival of 18.6 months when Gliadel Wafer and

SR Pharma plc, of London, raised £3.8 million (US$7.2 million) through the sale of 20 million shares at 19 pence (US$36 cents) per share to fund development programs and provide working capital...Subsidiaries of SR Pharma include Berlin-based Atugen AG, which specializes in RNAi therapeutics, and London-based Stanford Rook Ltd., which is seeking to license its clinical-stage Mycobacterium vaccae-based technology and related products for asthma, cancer and tuberculosis.

Researchers at Johns Hopkins, Fox Chase Cancer Center and the National Cancer Institute are testing Morphotek's second clinical-stage drug, MORAb-009, against pancreatic, non-small cell lung and ovarian cancers, as well as mesothelioma (a rare form of cancer usually associated with exposure to asbestos...Some big pharma firms feel the same way, but not all...Some companies want to see more clinical validation, and are happy to pay more

ImmunoGen Inc., of Cambridge, Mass., began clinical testing of AVE1642, an antibody designed to bind to the insulin-like growth factor-1 receptor that is expressed on many cancers...Nutra Pharma Corp., of Boca Raton, Fla., said its subsidiary, ReceptoPharm, received approval in the UK to begin its Phase IIb trial of RPI-78M in adrenomyeloneuropathy, a rare inherited metabolic disorder characterized by the loss of the myelin sheath on nerve fibers within the brain and adrenal atrophy

The results represent the first clinical evaluation of a vero cell-based candidate H5N1 pandemic vaccine...Novagali Pharma SA, of Evry, France, completed enrollment of patients ahead of schedule in a pivotal multi-center Phase III program to evaluate the efficacy and safety of Nova22007 for vernal keratoconjunctivitis...The duration of morning stiffness (the primary clinical endpoint of the study) was significantly reduced in the Lodotra group while under standard IR prednisone no change in morning

Nitec Pharma AG, of Basel, Switzerland, said it saw positive results in a Phase III clinical trial with Lodotra, a new, modified-release tablet that has been developed to optimize the efficacy of orally administered low-dose prednisone in rheumatoid arthritis...NovaDel Pharma Inc., of Flemington, N.J., said it had positive results from a pharmacokinetic study of its improved oral spray formulation of sumatriptan, the active ingredient in London-based GlaxoSmithKline plc's leading migraine remedy

BioAlliance Pharma SA, of Paris, reported that Phase I/II data of its doxorubicin Transdrug for primary liver cancer showed that a 30mg/m2 dose administered via intra-arterial hepatic injection showed an objective response of 16.7 percent in patients following a single injection...Those results were presented at the 7th international conference of the Asian Clinical Oncology Society in Beijing

Two big pharma-backed venture capital funds joined the Geneva-based company's roster of investors...The company aims to take ADX10059 through clinical development, and it plans to participate in its commercialization...Addex also is seeking near-term revenue opportunities by out-licensing additional clinical and preclinical drug candidates that are targeted at larger indications, which are beyond its scope

It is concentrating its resources on three clinical-stage programs: VX-950 (telaprevir) for chronic hepatitis C infection, which is in Phase IIb...The lead drug, VX-950, is partnered with Mitsubishi Pharma Corp., of Osaka, Japan, for the Far East and with Janssen for the rest of the world except North America, where Vertex retained the rights...Auxilium markets Testim 1 percent, a topical testosterone gel, to treat hypogonadism, and it has five projects in clinical development

The product was in-licensed from Tokyo-based Asahi Kasei Pharma Corp. (AKP), which has developed the product in Asian territories and recently submitted a new drug application in Japan...Leading up to the Series A round, AKP and NGN "worked to refine a clinical development plan and business plan," said Jeff Wager, president and CEO of Artisan...Medior was spun-out of Trellis Bioscience Inc., of South San Francisco.

Emisphere Technologies Inc., of Tarrytown, N.Y., said Novartis Pharma AG, of Basel, Switzerland, notified Emisphere of new Phase I data indicating that recombinant human growth hormone can be absorbed when given to growth hormone-deficient patients in a prototype oral formulation using Emisphere's eligen delivery technology...GTx Inc., of Memphis, said an independent Drug Safety Monitoring Board recommended that the company continue clinical development as planned with its two pivotal Phase III

NovaDel Pharma Inc., of Flemington, N.J., started a clinical trial for its formulation of zolpidem oral spray...Clinical trial site initiations and the enrollment of women for the trial began in late July, when the company announced it would submit applications to the FDA for the products: a screening test to detect the presence of 14 high-risk types of HPV and a genotyping test to detect two specific types of HPV-16 and 18, which cause about 70 percent of the cases of cervical cancer

ESBATech intends to start the first clinical trials of ESBA105 in 2007...The second candidate slated for clinical development within 18 months is the oncology drug ACE-041, a GDF antagonist that blocks angiogenesis, even in anti-VEGF resistant tumors...Esprit Pharma Inc., of East Brunswick, N.J., completed a Series B round, raising about $90.8 million, with participation from New Enterprise Associates, Apax Partners Inc., Domain Associates LLC and Montagu Newhall Global Partners, as well as new

Clinical trials are expected to begin later this year...MGI Pharma Inc., of Minneapolis, said the European Medicines Agency has granted Dacogen (decitabine) for Injection orphan designation in acute myeloid leukemia...Dacogen is being co-developed by MGI Pharma and Janssen-Cilag, a unit of New Brunswick, N.J.-based Johnson & Johnson

Abiogen Pharma, of Pisa, Italy, started a Phase II trial of its anti-anxiety drug, ABIO 08-01, in Vienna, Austria, in patients that have generalized anxiety disorder...Cell Genesys Inc., of South San Francisco, said clinical results of GVAX immunotherapy for prostate cancer in patients with early stage disease were published in a June issue of Clinical Cancer Research

BioAlliance Pharma SA, of Paris, presented preliminary results from its Doxorubicin Transdrug Phase I/II trial for primary liver cancer, at the 12th International Symposium on Viral Hepatitis and Liver Disease in Paris...Dendreon Corp., of Seattle, disclosed publication of results of a pivotal Phase III study (D9901) of Provenge, in the July issue of the Journal of Clinical Oncology