Company Executive Salary ($k) Bonus ($k) Total Cash ($k) Other ($k) Long-term ($k) Total direct ($k) Options* ($k) Stocks* ($k) ACHILLION PHARMA Gautam Shah 265 61 326 16 526 868 AFFYMAX Robert F. Venteicher 314 59 373 4 629 1006 ALEXION PHARMA David W. Keiser1 400 400 15 270 684 5947 248 ALEXZA PHARMACTCLS Michael J. Simms 315 88 403 18 390 811 ALKERMES Gordon G. Pugh 353 1080 1434 73 1956 3463 62 57 ALLOS THERAPEUTICS James V. Caruso

James V. Cassella ALEXZA PHARMACTCLS 321 49 369 85 R. Michael Gendreau CYPRESS BIOSCIENCE 313 55 367 86 Brian Dickson CORNERSTONE THERAPEUTICS 270 95 365 87 Peter K. Working CELL GENESYS 364 0 364 88 John M. Lambert IMMUNOGEN 295 68 363 89 Brian P. Zambrowicz LEXICON PHARMACEUTICALS 363 0 363 90 Roger Mills ACADIA PHARMACEUTICALS 361 0 361 91 Brian Schwartz ARQULE 313 47 360 92 Mark Gurney DECODE GENETICS 360 0 360 93 Philip Jochelson

James V. Cassella 321 49 369 76 246 692 0 0 ALKERMES Elliot W. Ehrich 354 130 484 8 551 1,042 183 57 ALLOS THERAPEUTICS Pablo J. Cagnoni 401 170 571 5 832 1,409 0 102 ALNYLAM PHARMA John A. Schmidt Jr

390 195 585 5 Gustav Christensen DYAX CORP 374 200 574 6 Tristan B. Orpin ILLUMINA INC 351 218 569 7 James V. Caruso ALLOS THERAPEUTICS INC 396 169 565 8 Geoffrey M. Nichol MEDAREX INC 414 144 558 9 Mark R. Baker J.D

Company Executive Salary ($k) Bonus ($k) Total Cash ($k) Other ($k) Long-term ($k) Total direct ($k) Options* ($k) Stocks* ($k) ACADIA PHARMA John Kaiser 277 111 388 80 90 558 0 0 ACCELRYS Richard C. G. Murphy1 299 15 315 425 62 802 0 58 ACCESS PHARMA Phillip S. Wise 200 0 200 10 137 347 0 0 AFFYMAX Paul B. Cleveland 334 122 456 4 636 1,095 0 0 ALEXZA PHARMA Anthony G. Tebbut2 321 46 367 76 314 757 0 0 ALLOS THERAPEUTICS James V

James V. Cassella ALEXZA PHARMACTCLS INC 303 59 363 95 Penny M. Heaton NOVAVAX INC 261 99 360 96 Daniel Hartman DECODE GENETICS INC 360 - 360 97 Stephen Uden NEUROGEN CORP 350 - 350 98 Philip Jochelson SOMAXON PHARMACEUTICALS INC 278 71 350 99 Paolo Baroldi VANDA PHARMACEUTICALS INC 277 72 349 100 Trevor Hallam PALATIN TECHNOLOGIES INC 305 42 347 101 Robert Segal DISCOVERY LABORATORIES INC 273 70 343 102 David K. Bol AVALON PHARMA INC 275 62

James V. Cassella 303 59 363 24 164 552 - - ALLOS THERAPEUTICS Pablo J. Cagnoni5 380 225 605 4 721 1,331 - - AMAG PHARMA Jerome M. Lewis 225 94 319 35 228 583 1,419 62 AMGEN Roger M. Perlmutter 908 605 1,513 1,564 1,635 4,713 - - AMYLIN PHARMA Alain D. Baron 395 68 463 0 1,084 1,548 1,683 6 ANESIVA Daniel J. Gennevois6 441 - 441 4 223 669 - - ANTIGENICS Roman Chicz7 285 - 285 232 86 604 - - ARENA PHARMA Dominic P. Behan 370

For the 76 business and corporate development executives in BioWorld s company survey who received base salary plus bonus Rank Executive Company Salary ($k) Bonus ($k) Total ($k) 1 George J. Morrow AMGEN INC 961 640 1,601 2 Barry A. Labinger HUMAN GENOME SCIENCES INC 460 205 665 3 Geoffrey M. Nichol MEDAREX INC 400 191 591 4 John A. Keller INCYTE CORP 339 245 584 5 Philip K. Yachmetz SAVIENT PHARMACEUTICALS INC 357 222 579 6 James V. Caruso ALLOS

Company Executive Salary ($k) Bonus ($k) Total Cash ($k) Other ($k) Long-term ($k) Total direct ($k) Options ($k) Stocks ($k) ACADIA PHARMA Roger Mills1 342 85 427 0 164 593 - - ACCELRYS R. William Taylor 240 98 338 0 144 483 - - ACCESS PHARMA Phillip S. Wise 200 - 200 9 - 209 - - ALEXZA PHARMA Anthony G. Tebbut2 304 48 353 159 266 778 - - ALKERMES Michael J. Landine 315 160 475 6 961 1,443 - 85 ALLOS THERAPEUTICS James V. Caruso3 377

James V. Cassella ALEXZA PHARMACTCLS INC 289 57 345 121 Stephen R. Lee ORASURE TECHNOLOGIES INC 268 75 343 122 Lee L. Rubin CURIS INC 339 0 339 123 Philip Jochelson SOMAXON PHARMACEUTICALS INC 263 74 337 124 Daniel L. Weiner PHARSIGHT CORP 260 73 333 125 Nebojsa Janjic REPLIDYNE INC 275 57 332 126 Jack R. Barber CYTRX CORP 262 69 331 127 Kenneth S. Kornman INTERLEUKIN GENETICS INC 331 0 331 128 Michael B. Stewart SONUS PHARMACEUTICALS INC 331 0

James V. Cassella 289 57 345 37 82 464 0 0 ALLOS THERAPEUTICS INC Michael E. Saunders (3) 263 63 326 2 122 450 0 0 ALTUS PHARMACEUTICALS INC Alexey L. Margolin 295 96 391 11 100 502 0 0 AMGEN INC Roger M. Perlmutter 884 1,645 2,529 2,022 5,509 10,060 0 0 AMYLIN PHARMA Alain D. Baron 367 248 615 1 891 1,506 1,636 15 ANADYS PHARMA Devron R. Averett 250 40 290 4 353 647 16 0 ANTIGENICS INC/DE Roman Chicz 285 86 370 12 193 575 0 0

James V. Caruso ALLOS THERAPEUTICS INC 211 74 284 62 William J. Welch MONOGRAM BIOSCIENCES 283 0 283 63 Dushyant Pathak RENOVIS INC 281 0 281 64 W. Charles Montgomery ATHEROGENICS INC 280 0 280 65 Frederick Finnegan CRITICAL THERAPEUTICS INC 278 0 278 66 John F. Womelsdorf CYCLACEL PHARMA 250 25 275 67 Marc G. Corrado ENTREMED INC 220 55 275 68 Fred L. Vitale HANA BIOSCIENCES INC 200 75 275 69 Philip J. Young INSMED INC 268 0 268 70 James H

James V. Caruso (2) (3) ALLOS THERAPEUTICS INC 211 74 284 94 332 710 0 0 Vincent J. Miles ALNYLAM PHARMACEUTICALS INC 252 38 289 4 254 547 1,336 0 Peter S. Lawrence (4) ARQULE INC 361 97 458 3 239 598 0 0 David L. Snitman ARRAY BIOPHARMA INC 271 94 365 19 0 384 0 0 Charles Montgomery ATHEROGENICS INC 280 0 280 14 469 763 0 0 Jyrki Mattila AUXILIUM PHARMA INC 315 115 430 7 163 601 0 25 James H. Meade (5) AVALON PHARMA INC 230 37 267

James V. Cassella (58) 219 20 239 24 0 263 63 0 Northwest Biotherapeutics Inc

Alan McClelland (12) 239 0 239 101 Neurogen Corporation James V. Cassella (58) 219 20 239 102 Inspire Pharmaceuticals Inc

Definitions & methodology Using the same 225 proxy statements, we have gathered data on the compensation of executives responsible for Research & Development (R&D) in the industry. The sample size of companies shrinks to 144 in the case of this position because many companies have no such position listed among the top wage earners (companies disclose compensation only for the five most highly paid executives or, in the case of small companies, for executives who earn more than $100,000). In

Definitions & Methodology Using the same 259 proxy statements, we have gathered data on the compensation of executives responsible for Research & Development (R&D) in the industry. The sample size of companies shrinks to 188 in the case of this position because many companies have no such position listed among the top wage earners (companies disclose compensation only for the five most highly paid executives or, in the case of small companies, for executives who earn more than $100,000). In