Rank Name of Executive Age Company FYE Value of Exercisable In-the-Money Options ($000) Total No. of Shares Owned By CEO # (000) Percent of Co. Stock Owned By CEO ## (%) Stock Price 12/31/02 ($) Stock Price 12/31/03 ($) Percent Change Stock Price (%) 1 Arthur Levinson 54 Genentech Inc. 124,078 2,111,821 33.16 93.57 182.2 2 John Martin 52 Gilead Sciences Inc. 74,189 2,024,150 34 58.28 71.4 3 Henri Termeer 58 Genzyme Corp. 51,735 3,237,831 1.4 29.57 49.29

Address 515 Galveston Drive, Redwood City, CA 94063. Phone number (650) 298-5300. Fax number (650) 364-2715 Internet address www.maxygen.com Management Russell Howard, CEO Simba Gill, president Lawrence Briscoe, senior vice president and CFO Paul Spence, senior vice president of research and development Year Established 1997 (spun off from GlaxoWellcome plc) IPO Year 1999; NASDAQ:MAXY Employees Approximately 300 Business/Strategy Maxygen Inc. optimizes genes and proteins

Company Stock Price 12/31/01 Stock Price 12/31/02 Stock Price Change(%) Shares Out (M)* Mkt. Cap. (M)** 3-Dimensional Pharmaceuticals Inc. (Nasdaq:DDDP) 8.4900 3.2300 -62.0 22.6 73.0 Aclara Biosciences Inc. (Nasdaq:ACLA) 5.0700 2.1000 -58.6 36.2 76.0 Affymetrix Inc. (Nasdaq:AFFX) 37.7500 22.8900 -39.4 58.4 1,336.8 Agilent Technologies Inc. (NYSE:A) 28.5100 17.9600 -37.0 471.2 8,462.8 Applied Biosystems Group (NYSE:ABI) 39.2700 17.5400 -55.3 209.2 3,669.4

Name Description Size (kb) Aeropyrum pernix First aerobic member of the Archaea to be sequenced; grows optimally at 95C (203 F) 1,669 Agrobacterium tumefaciens C58-Cereon Major plant pathogen; causes disease by transferring its own DNA into plant cells 4,915 Agrobacterium tumefaciens C58-DuPont Major plant pathogen; causes disease by transferring its own DNA into plant cells 4,915 Anabaena Cyanobacterium; increases nitrogen content of soil to provide an important source of natural

Address 1000 Marina Boulevard, Suite 450, Brisbane, CA 94005 Phone number (650) 829-2600 Fax number (650) 829-2647 Internet address www.x-mine.com Management Sandip Ray, president and CEO Thomas Neff, chairman Todd Golub, director Tadashi Matsumoto, director Rory Riggs, director Year Established 2000 Employees 4 Business/Strategy X-Mine Inc. is a biological data mining and knowledge discovery company founded by leaders in the field of genomics from the MIT/Whitehead Institute

Address 111 West Lemon Avenue, Monrovia, CA 91016 Phone number (626) 305-5900 Fax number (626) 305-0350 Internet address www.xencor.com Management Bassil Dahiyat, president and CEO Stephen Doberstein, vice president of chemical biology Joyce Morrison, vice president of intellectual property E. William Radany, chief business officer Year Established 1997 Employees 73 Business/Strategy Xencor Inc. discovers and develops protein and small-molecule therapeutics using its rational

Address 6H Gill Street, Woburn, MA 01801 Phone number (781) 937-5550 Fax number (781) 938-0060 Internet address www.usgenomics.com Management Eugene Chan, chairman and CEO David Hoey, vice president of business development Michael Olex, senior vice president of general management Year Established 1997 Employees Approximately 35 Business/Strategy U.S. Genomics Inc. is developing technologies for direct, linear analysis of DNA for the global life sciences industry. The company's

Address Wagistrasse 27, 8952 Schlieren, Zurich, Switzerland Phone number +41 4 4 200 2200 Fax number +41 4 4 200 2211 Internet address www.the-genetics.com Management Harald Eistetter, CEO Andreas Ziegler, CFO Ernst Hafen, co-founder and scientific director Mario Jenni, co-founder and COO Year Established 1998 Employees 26 Business/Strategy The Genetics Company Inc. works in the field of high-throughput in vivo functional genomics, or invonomics. The company has compiled

Address 1745 38th Street, Boulder, CO 80301 Phone number (303) 625-9000 Fax number (303) 545-2525 Internet address www.somalogic.com Management Larry Gold, CEO Scott Kothlow, director of finance and administration Joseph Heilig, senior director, science Keith Warner, chief commercialization officer John Vozella, senior director, regulatory affairs and quality assurance Year Established 1999 Employees 55 Business/Strategy SomaLogic Inc. is researching proteomics and clinical

Address 400 West Cummings Park, Suite 2850, Woburn, MA 01801 Phone number (781) 938-3830 Fax number (781) 938-3880 Internet address www.silicoinsights.com Management Dinesh Patel, chairman John Babish, vice president of research Nandan Padukone, president and COO Christos Hatzis, vice president of technology Lynne Selinger, associate director of corporate operations Year Established 2000 Employees 12 Business/Strategy Silico Insights Inc. uses its i-Sight Discovery technology

Address 14 Tech Circle, Natick, MA 01760 Phone number (508) 650-1459 Fax number (508) 655-1625 Internet address www.sequiturinc.com Management Tod Woolf, president Year Established 1996 Employees 25 Business/Strategy Sequitur Inc. discovers and validates pharmaceutical target genes through commercial alliances with pharmaceutical and biotechnology partners. Its functional genomics technology helps to identify the triggers of disease during drug discovery, using antisense and RNAi

Address 4370 Varsity Drive, Suite G, Ann Arbor, MI 48108 Phone number (734) 677-2893 Fax number (734) 477-9902 Internet address www.rubicongenomics.com Management Fred Beyerlein, president and CEO Linda Palka, director of finance and administration, controller and secretary/treasurer Vladimir Makarov, co-founder and CSO John Langmore, co-founder and vice president of commercial development Houng-Yau Mei, vice president of operations Year Established 1998 Employees 16 Business

Address 270 Littlefield Avenue, South San Francisco, CA 94080 Phone number (650) 266-1400 Fax number (650) 266-1460 Internet address www.renovis.com Management Corey Goodman, director, president and CEO John Doyle, vice president and CFO Tito Serafini, chief discovery scientist and vice president of genomic research Lynne Zydowsky, COO, director and senior vice president of business development Year Established 2000 Employees 37 Business/Strategy Renovis Inc. utilizes a

Address 26101 Research Road, Hayward, CA 94545 Phone number (510) 266-7500 Fax number (510) 784 2569 Internet address www.zyomyx.com Management Lawrence Cohen, president and CEO Garrett Roper, senior vice president and CFO Peter Wagner, senior vice president and chief technology officer Hirdey Bhathal, vice president of corporate development Steffen Nock, vice president of biochemistry Year Established 1998 Employees 41 Business/Strategy Zyomyx Inc. is developing and

Address 44 Hartwell Avenue, Lexington, MA 02421 Phone number (781) 274-6500 Fax number (781) 274-0839 Internet address www.zycos.com Management Mark Philip, president and CEO Roman Chicz, vice president of discovery research Mary Lynne Hedley, vice president of research Kathleen Beach, vice president of medical affairs Robert Urban, vice president, new technologies and targets Year Established 1996 Employees N/A Business/Strategy Zycos Inc. is a drug discovery and development

Address Fraunhoferstrasse 9, D-82152 Martinsried, Germany Phone number +49 8986 3070 Fax number +49 8986 3071 11 Internet address www.xerion-pharma.com Management Markus Ewert, president and CEO Peter Biewald, CFO Leodevico Ilag, CSO Year Established 1998 Employees Approximately 50 Business/Strategy Xerion Pharmaceuticals AG is a trans-Atlantic biopharmaceutical company focused on generating highly qualified drug targets and therapeutic antibody leads. The company uses

Address 3650 Gilmore Way, Burnaby, British Columbia, Canada V5G 4W8 Phone number (604) 484-3300 Fax number (604) 484-3450 Internet address www.xenongenetics.com Management Frank Holler, president and CEO Leonard Cox, senior director, finance Michael Hayden, CSO Karen Corraini, legal counsel and director, business development Guy Rouleau, research head, Xenon Genetics Research Inc. Year Established 1997 Employees Approximately 35 Business/Strategy Xenon Genetics Inc. is a

Address Fraunhoferstrasse 22, 82152 Martinsried, Germany Phone number +49 8989 9594 00 Fax number +49 8989 9594 20 Internet address www.xantos-bio.de Management Peter Buckel, CEO Stephan Wehselau, CFO Christoph Hergersberg, CSO David Chilvers, chief business officer Year Established 1999 Employees 60 Business/Strategy Xantos Biomedicine AG uses its functional genomics technologies to enable rapid identification of disease-relevant targets and drugs. It uses its XantoScreen high

Address Warthestrasse 21, D-14513 Teltow/Berlin, Germany Phone number +49 3328 3508 61 Fax number +49 3328 3508 60 Internet address www.wita-proteomics.com Management Andreas Kpke, chairman and CEO Wolfgang Krmer, director of scientific operations Ulrich Wacker, director of scientific project management Pascal Bolon, director of sales and marketing Birgit Throne-Kromer, QM manager Year Established 2001 (spun out from WITA GmbH) Employees 20 Business/Strategy WITA Proteomics AG