It was established in 2007 by investment bankers Burrill & Co., of San Francisco, and Kuwait Life Sciences Co., the life sciences arm of Kuwait's National Technology Enterprises Co. (NTEC), in order to in-license and market biologic and small-molecule drugs in the Middle East, Africa, Turkey and Caspian Sea region

Other data demonstrated that pharmacological inhibition of Usp14 by the company's small-molecule inhibitors stimulated degradation of the proteins in cell, neuron and brain slice models, suggesting the compounds' potential in a number of protein aggregation-related neurodegenerative disorders

Harvard and Evotec will work together to identify and optimize small-molecule inhibitors for the targets based on technologies licensed from Harvard

It was established in 2007 by investment bankers Burrill & Co., of San Francisco, and Kuwait Life Sciences Co., the life sciences arm of Kuwait's National Technology Enterprises Co. (NTEC), in order to in-license and market biologic and small-molecule drugs in the Middle East, Africa, Turkey and Caspian Sea region

They also plan to search for small molecules that will be able to mimic the activity of the peptides they have described

The goal of Effector – named after the effector mechanism required by many oncogenes – is to develop small molecules that can restore homeostasis, reversing the disregulation that leads to disease...Karyopharm's platform technology – a rapid chemical optimization system with integrated computational/in silico rational drug design – yielded multiple small-molecule SINEs aimed at forcing the nuclear localization of major tumor suppressor and growth regulatory proteins, which cause selective death of

It was established in 2007 by investment bankers Burrill & Co., of San Francisco, and Kuwait Life Sciences Co., the life sciences arm of Kuwait's National Technology Enterprises Co. (NTEC), in order to in-license and market biologic and small-molecule drugs in the Middle East, Africa, Turkey and Caspian Sea region

Inc. (Whitehouse Station, N.J.) $86.5 Exercised option for Merck to exclusively license small-molecule compounds for a target in cardiovascular disease The companies inked the deal in 2009, and under the terms, Xenon received milestone payments and an option fee and is eligible for further research, development and regulatory milestone payments of up to $86.5M 4/18/13 MAY Hyperion Therapeutics Inc. (South San Francisco) Valeant Pharmaceuticals International Inc. (Montreal) $13-$22 Hyperion

Total Value in 2013: $6,192M* Number of Deals in 2013: 97 Company (Location) Company (Location) Value (M) Type/Product Area Terms/Details Date APRIL Alchemia Ltd. (Brisbane, Australia) AstraZeneca AB (Sodertalje, Sweden; unit of AstraZeneca plc) $240 Deal for Alchemia's Diversity Scanning Array and Versatile Assembly on Stable Templates technologies to discover and develop small molecules for multiple targets in the oncology, respiratory, cardiovascular, metabolism, infection and neuroscience

Clinical trials involving personalized cellular therapies are closely supervised by the FDA, because while small-molecule drugs are static, destined to have a certain efficacy and safety profile, cellular therapies intrinsically vary between patients – and that variation is magnified by having not just a different patient each time, but a different egg donor for each patient

In 2007, the company inked a blockbuster deal with Pfizer Inc., of New York, focused on its Gene Expression Modulation by Small-molecules (GEMS) technology platform, which identifies small molecules that regulate post-transcriptional control mechanisms

Labeta and his team hope to bring the approach into the clinic, either with peptides themselves or with small molecules

Harvard and Evotec will work together to identify and optimize small-molecule inhibitors for the targets based on technologies licensed from Harvard

In its S-1 filing, Esperion, of Plymouth, Mich., is looking to raise $70 million to boost work on its oral small molecule for lowering low-density lipoprotein cholesterol (LDL-C...An oral small molecule, ETC-1001 is designed as an alternative to statin therapy such as Lipitor (atorvastatin, Pfizer

While those local compounders still exist, the lack of oversight has led to the emergence of a new industry that compounds both small-molecule drugs and biologics in bulk and markets them throughout the country

Ablynx NV, of Ghent, Belgium, initiated preclinical development of next-generation anti-IgE Nanobody ALX-0962 in severe allergic asthma. ALX-0962 consists of a potent anti-IgE Nanobody with a dual mode of action – the ability to bind with high affinity to IgE while also displacing receptor-bound IgE – together with a serum albumin binding Nanobody for in vivo plasma half-life extension. BioAlliance Pharma SA, of Paris, reported the International Independent Board of Experts' data and safety

What is more, they have already found a small molecule that blocks the receptor, and they have crystallized the binding pocket, which should make it possible to design or find other small molecules that can be used as drugs to inhibit the growth of breast cancer cells...The small molecule that de Boer and his colleagues have used to block the estrogen receptor is called fusicoccin, which is a product of the fungus Phomopsis amygdali

sales force, a pipeline of small molecules and early stage discovery capabilities

ProQinase GmbH, of Freiburg, Germany, and Mercachem BV, of Nijmegen, the Netherlands, received a €2.5 million (US$3.24 million) grant from the European Union's Eurostars program to support their joint efforts to establish and expand a small molecule drug discovery platform that will combine biological and pharmacological assay systems with chemical space libraries targeted against most prominent epigenetic enzyme families