The San Francisco-based company said proceeds, raised exclusively from existing shareholders and partner companies, will advance the clinical development of Pexa-Vec in HCC and in the follow-on indication of refractory colorectal cancer

Galapagos NV, of Mechelen, Belgium, and AbbVie Inc., of Chicago, extended their clinical development collaboration on the oral JAK1 inhibitor GLPG0634 to include Crohn's disease...The pharma also will assume responsibility for funding and clinical development beyond Phase II and for completing regulatory and commercialization activities

Ltd. (Seoul, South Korea) ND Licensing agreement for the anti-angiogenic peptide ALM201 for clinical development and marketing in South Korea Shin Poong will make undisclosed up-front and milestone payments, along with royalties 4/30/13 Ambrx Inc. (San Diego) Astellas Pharma Inc. (Tokyo) $300 Oncology-focused discovery and development collaboration in antibody drug conjugates Ambrx will receive $15M up front, and up to $285M in research, development, regulatory and sales-based milestones for an

announced its first miRNA candidate for clinical development, RG-101, which also targets miR-122

In its filing, the company said it plans to use proceeds from the IPO to fund the clinical development of lead candidate ataluren (formerly PTC124) in Duchenne's muscular dystrophy caused by nonsense mutations (nmDMD) and cystic fibrosis caused by nonsense mutations (nmCF), to seek marketing approval of ataluren in the indications in the U.S

Galapagos NV, of Mechelen, Belgium, and AbbVie Inc., of Chicago, extended their clinical development collaboration on the oral JAK1 inhibitor GLPG0634 to include Crohn's disease...The pharma also will assume responsibility for funding and clinical development beyond Phase II and for completing regulatory and commercialization activities

These 290 patients served as a base of clinical experience prior to kicking off our clinical development," Wuite told BioWorld Today

Genor BioPharma has more than 100 employees with 10 products in the pipeline, three at the IND or clinical-development stage

Merck Serono SA, of Rockland, Mass., a division of Merck KGaA, of Darmstadt, Germany, and Quintiles Inc., of Research Triangle Park, N.C., signed a new, five-year clinical development agreement

In April 2014, Astellas said clinical development, quality assurance, regulatory affairs and pharmacovigilance functions – all currently located in Itabashi-ku, Tokyo – will be "relocated and consolidated" closer to the company's headquarters in Nihonbashi, Chuo-ku, Tokyo

is more than doubling its cash position with a $30 million registered direct offering, with proceeds to fund R&D activities, namely clinical development of DX-2930, a drug slated to start clinical development for prophylactic use in hereditary angioedema (HAE

Moving Quickly While most drugs languish in clinical trials for upwards of a decade, Zelboraf and Xalkori were able to move quickly, largely due to the fact that both were paired with companion diagnostics very early in their clinical development, allowing them to find the right patient population, establish efficacy and present a convincing case to regulators. (See BioWorld Insight, Sept. 6, 2011.) "Early development of these tests also potentially enables clinical trials to be smaller and more

A partnership signed with Clovis Oncology Inc., of Boulder, Colo., last year, for example, calls for Clovis to be fully responsible for all aspects of preclinical and clinical development and commercialization of compounds discovered by Array

clinical development plan and financial terms relating to ISIS-TTRRx to reflect an accelerated development plan for that antisense drug...Isis has 28 candidates in preclinical and clinical development across a wide variety of indications, with nine scheduled to report data in the next 12 months

In other words, if the protein is effective, clinical development might be more rapid than in cases where a drug candidate has to be identified to recapitulate an effect

CytRx said it will focus on clinical development of aldoxorubicin and expansion of its oncology pipeline, based on its linker platform technology...Nimbus will control and conduct research up to achievement of drug candidate status, at which point Shire will have an exclusive option to acquire the program and assume clinical development and future commercialization activities

Menarini will be responsible for manufacture and clinical development of each product, with OBT providing proprietary cancer targets, antibody generation and drug conjugation technologies

The mTOR kinase is a key regulator of growth, and it is targeted by hundreds of agents now in preclinical and clinical development...Such inhibitors are in clinical development, but like most targeted therapies, work only for a time until tumors mutate their way around them

In terms of further clinical development of the antibodies, one question is – as always – how well the effects in mice predict those in people