January | February | March | April | May | June | July | August | September | October | November | December | December - 2010 Biotech Company Pharma Company Type/Product Area Terms/Details Adamis Pharmaceuticals Corp. (OTC BB:ADMP) Beximco Pharmaceuticals Ltd. (Bangladesh) Partnership to introduce four separate drugs in the area of allergy and asthma in the U.S. over three years The two companies also will co-develop other drugs Anaphore Inc. Mitsubishi Tanabe Pharma Corp
January | February | March | April | May | June | July | August | September | October | November | December COMPLETED MERGERS AND ACQUISITIONS - December 2010 Company Acquired Acquired By Or Merged With Date Announced Date Completed Value (M) Terms/Details Avid Radiopharmaceuticals Inc. Eli Lilly and Co. 11/9/10 12/22/10 $300 Lilly paid $300M to buy Avid, which could earn $500M more based on a milestones Genzyme Genetics (unit of Genzyme Corp.; GENZ) Laboratory Corp. of America (NYSE:LH) 9/14
Public Companies | Private Companies PUBLIC COMPANIES - December 2010 Company (Symbol) Type Of Financing Number Of Shares, Units Or Warrants (M) Amount Raised (US$M) Access Pharmaceuticals Inc. (OTC BB:ACCP) Registered direct offering 2.3S $6 Anavex Life Sciences Corp. (OTC BB:AVXL) Private placement of units 0.03U $0.1 Bavarian Nordic A/S (Denmark; CSE:BAVA) Private placement of shares 1.05S DKK205 ($36.2) BioSante Pharmaceuticals Inc. (BPAX) Registered direct
January | February | March | April | May | June | July | August | September | October | November | December | December - 2009 Biotech Company Pharma Company Type/Product Area Terms/Details Adimab Inc. Pfizer Inc.; an undisclosed company Agreement for Adimab to deliver fully human antibodies against a central nervous system target selected by Pfizer; the new deal with the undisclosed company will focus on an oncology target Both deals involve up-front fees, milestone payments
January | February | March | April | May | June | July | August | September | October | November | December COMPLETED MERGERS AND ACQUISITIONS - December 2009 Company Acquired Acquired By Or Merged With Date Announced Date Completed Value (M) Terms/Details Applied Genomics Inc. Clarient Inc. (CLRT) 12/22/09 12/22/09 $17.6 Clarient acquired Applied Genomics in an all-stock merger involving 7.6M shares Avigen Inc. (AVGN) MediciNova Inc. (MNOV) 6/25/09 12/18/09 $37 MediciNova acquired Avigen for
Public Companies | Private Companies PUBLIC COMPANIES - December 2009 Company (Symbol) Type Of Financing Number Of Shares, Units Or Warrants (M) Amount Raised (US$M) Advaxis Inc. (OTC BB:ADXS) Sale of FY08 net operating tax losses and research tax credits N/A $0.3 Amsterdam Molecular Therapeutics BV (the Netherlands; Euronext:AMT) Private placement of convertible bonds N/A E5 ($7.3) Arrowhead Research Corp. (ARWR) Private placement of units 5U $3.2 AVAX
Commenced Trading COMMENCED TRADING - December 2009 INITIAL OFFERINGS Company Date Filed Date Comm. Shares/Units (M) Price Shares Out (M) Gross (M) Movetis (Belgium; Euronext:MOVE) 12/4/09 12/4/09 6.9S E12.25 N/A E85 ($126) COMMENCED TRADING - November 2009 INITIAL OFFERINGS Company Date Filed Date Comm. Shares/Units (M) Price Shares Out (M) Gross (M) No initial public offerings commenced in November. COMMENCED TRADING - October 2009 INITIAL
January | February | March | April | May | June | July | August | September | October | November | December | December - 2009 Company Company Type/Product Area Terms/Details Alkermes Inc. (ALKS) Acceleron Pharma Inc. Licensing agreement for a long-acting Fc fusion technology platform Alkermes gains worldwide rights to Medifusion in return for an up-front payment and equity investment in Acceleron, plus future milestones and royalties Allos Therapeutics Inc. (ALTH) Idis
January | February | March | April | May | June | July | August | September | October | November | December | December - 2008 Company Company Type/Product Area Terms/Details AAIPharma Inc. (PK:AAIIQ) Cortria Corp. Agreement granting Cortria the right to use AAIPharma's controlled-release drug delivery technology, ProCR, in conjunction with its TRIA-662 TRIA-662 is Cortria's lead candidate in Phase II development for dyslipidemia Advanced Cell Technology Inc. (PK:ACTC) CHA
January | February | March | April | May | June | July | August | September | October | November | December | December - 2008 Biotech Company Pharma Company Type/Product Area Terms/Details Acura Pharmaceuticals Inc. (ACUR) King Pharmaceuticals Inc. Exercised option to license a fourth immediate-release opioid analgesic product candidate using Acura's Aversion technology, which is designed to deter common methods of prescription drug misuse and abuse King paid Acura an option
January | February | March | April | May | June | July | August | September | October | November | December COMPLETED MERGERS AND ACQUISITIONS - December 2008 Company Acquired Acquired By Or Merged With Date Announced Date Completed Value (M) Terms/Details Nucleonics Inc. Alnylam Pharmaceuticals Inc. (ALNY) 12/8/08 12/8/08 ND Alnylam acquired the intellectual property assets of Nucleonics Omrix Biopharmaceuticals Inc. (OMRI) Johnson & Johnson 11/24/08 12/31/08 $438 J&J acquired Omrix for
Public Companies | Private Companies PUBLIC COMPANIES - December 2008 Company (Symbol) Type Of Financing Number Of Shares, Units Or Warrants (M) Amount Raised (US$M) Aeolus Pharmaceuticals Inc. (OTC BB:AOLS) Private placement of senior convertible notes and warrants ND $0.125 AMDL Inc. (AMEX:ADL) Private placement of 12% senior notes and warrants ND $1.08 Ardea Biosciences Inc. (RDEA) Private placement of common stock and warrants 2.7S and W for 0.68S $30.6
Follow-on Offerings FOLLOW-ON OFFERINGS - October - December 2008 Company Date Filed Date Comm. Shares/Units (M) Price Gross (M) There were no follow-on offerings in October, November and December FOLLOW-ON OFFERINGS - September 2008 Company Date Filed Date Comm. Shares/Units (M) Price Gross (M) Vertex Pharmaceuticals Inc. (VRTX) 9/18 9/18 8.625S $25.50 $219.9 FOLLOW-ON OFFERINGS - August 2008 Company Date Filed Date Comm. Shares/Units (M
Commenced Trading COMMENCED TRADING - July - December 2008 INITIAL OFFERINGS Company Date Filed Date Comm. Shares/Units (M) Price Shares Out (M) Gross (M) No initial public offerings commenced in July, August, September, October, November and December COMMENCED TRADING - June 2008 INITIAL OFFERINGS Company Date Filed Date Comm. Shares/Units (M) Price Shares Out (M) Gross (M) PCI Biotech Holding ASA (Norway; OSLO:PCIB) 6/11/08 6/11/08 3S NOK20 ($3.9) 5.4
Follow-on Offerings FOLLOW-ON OFFERINGS - December 2007 Company Date Filed Date Comm. Shares/Units (M) Price Gross (M) Anesiva Inc. (ANSV) 12/13/07 12/26/07 12.3S $4.05 $49.8 EpiCept Corp. (EPCT) 10/14/07 12/4/07 3.3S and W for 1.75S $1.50 $4.95 FOLLOW-ON OFFERINGS - November 2007 Company Date Filed Date Comm. Shares/Units (M) Price Gross (M) Arena Pharmaceuticals Inc. (ARNA) 10/22/07 11/2/07 11S $9.91 $109.01 Biopure Corp. (BPUR) 11
January | February | March | April | May | June | July | August | September | October | November | December December - 2007 Company Company Type/Product Area Terms/Details Advanced Viral Research Corp. (ADVR) Cetek Corp. Agreement under which ADVR acquired certain assets, including rights to two new anticancer compounds, as well as high-throughput affinity-based drug screening technology called AFP ADVR will receive rights to a microbial culture library for screening potential
January | February | March | April | May | June | July | August | September | October | November | December December - 2007 Biotech Company Pharma Company Type/Product Area Terms/Details Abeome Corp. Millipore Corp. Exclusive worldwide marketing and distribution agreement for rights to Abeome's stem cell monoclonal antibody Human Embryonic Stem Cell Antigen-1 Abeome received an undisclosed up-front payment and also will receive royalties on sales by Millipore Addex
January | February | March | April | May | June | July | August | September | October | November | December | December - 2010 Biotech Company Pharma Company Type/Product Area Terms/Details Adamis Pharmaceuticals Corp. (OTC BB:ADMP) Beximco Pharmaceuticals Ltd. (Bangladesh) Partnership to introduce four separate drugs in the area of allergy and asthma in the U.S. over three years The two companies also will co-develop other drugs Anaphore Inc. Mitsubishi Tanabe Pharma Corp