It already has completed a preclinical study in healthy rhesus monkeys and obtained preclinical proof of concept in the form of a favorable cytokine profile

S-TARget Therapeutics, of Vienna, Austria, said it achieved in vivo proof of concept for drug candidate SG100, which is in development for the prevention and therapy of severe allergic asthma caused by house dust mite (HDM) allergens

Ltd. (Osaka, Japan) ND For successfully determining a novel protein crystal structure of an undisclosed proprietary G-protein-coupled receptor drug discovery target 3/8/13 ThromboGenics NV (Leuven, Belgium) Alcon Inc. (unit of Novartis AG; Basel, Switzerland) €45 ($58.8) For formal European Union approval for Jetrea for treating patients with vitreomacular traction 3/18/13 Tris Pharma Inc. (Monmouth Junction, N.J.) Vernalis plc (Winnersh, UK) ND For its achievement of proof of concept for the

Last month, it inked a deal with AbbVie, of Chicago, giving the big pharma firm an option to RPC4046 following the Phase II proof-of-concept trial in EoE

Inhibitor Works, but Not as Suspected A team from Agios Pharmaceuticals Inc., along with academic and industrial collaborators, published proof-of-concept data that inhibiting the metabolic enzymes IDH-1 and IDH-2 can lead stem-like leukemia and brain tumor cells to differentiate into mature cells, which in turn stops them from continuing to divide

Earlier this year, Shape completed a proof-of-concept Phase Ib study of SHP-141 in psoriasis...The strategy is to generate clinical proof of concept with the molecule, then sell the company to a larger pharmaceutical company that can do the late-stage development and commercialization," Onsi said, adding that Healthcare Ventures plans to remain the sole venture partner

But over this year and next, its main priority will be to obtain clinical proof of concept for its two lead programs, as well scaling up manufacturing and identifying the appropriate regulatory pathways.

Galapagos said it intends to start a proof-of-concept study in ulcerative colitis patients in the second quarter

But over this year and next, its main priority will be to obtain clinical proof of concept for its two lead programs, as well scaling up manufacturing and identifying the appropriate regulatory pathways.

Founded in late 2005, Edison worked quietly for six years to demonstrate proof of concept on its translational platform, based on redox biochemistry – the foundation from which cells generate and regulate energy metabolism – and to bridge key discoveries in genetically confirmed pediatric rare mitochondrial diseases to major adult central nervous system disorders such as Alzheimer's disease and Parkinson's disease, where redox and mitochondrial dysfunction also may play a critical role

Galapagos said it intends to start a proof-of-concept study in ulcerative colitis patients in the second quarter

3SBio Inc., of Shenyang, China, called an extraordinary general meeting of shareholders for April 25 to vote on the merger plan with Decade Sunshine Ltd. and its wholly owned subsidiary Decade Sunshine Merger Sub. The merger would result in 3SBio becoming a privately held subsidiary of Decade Sunshine Ltd., with its American Depository Shares no longer listed on the Nasdaq Global Market. The company's board of directors approved the merger agreement and recommended that shareholders vote to

Kala just completed a Series A for $11.5 million through a consortium including Crown Venture Fund LLC, Lux Capital Management and Polaris Venture Partners in addition to Third Rock Ventures to advance its ophthalmic programs through clinical proof of concept

proof-of-concept trials 12/14/12 Genisphere Inc. (Hatfield, Pa.) Lankenau Institute for Medical Research Partnership To develop nanotherapeutic products for cancers and eye diseases The two organizations have an existing collaboration in the area of inflammatory bowel disease biomarkers centered on Genisphere's 3DNA dendrimer technology for delivery of a variety of therapeutic agents to cells 12/4/12 Gentium SpA (Villa Guardia, Italy) National University Corporation Hamamatsu University School

Summit plc, of Oxford, UK, said it plans to initiate a two-part proof-of-concept trial with lead candidate SMT-C1100 in Duchenne's muscular dystrophy (DMD

Until 2010, Genetix's key accomplishment was human proof-of-concept data for programs in CCALD and thalassemia

Soricimed Biopharma Inc., of Toronto, reported results from molecular imaging investigation that provided proof of concept for the use of SOR peptides to detect and potentially treat ovarian, breast, thyroid, prostate and colon cancer

GeNeuro is planning a proof-of-concept study after completion of an extension trial in early 2014

We will keep options open, but would like to get to clinical proof of concept in humans if we can."