Public Companies | Private Companies PUBLIC COMPANIES - December 2007 Company (Symbol) Type Of Financing Number Of Shares, Units Or Warrants (M) Amount Raised (US$M) Advanced Life Sciences Holdings Inc. (ADLS) Private placement of common stock 10.2S $20 Amarin Corp. plc (AMRN) Private placement of American depositary shares and warrants to buy ADSs; and a private placement of convertible notes 16.3ADSs and W for 8.1ADSs $8.1 Ardea Biosciences (IBPI) Private

Commenced Trading COMMENCED TRADING - December 2007 INITIAL OFFERINGS Company Date Filed Date Comm. Shares/Units (M) Price Shares Out (M) Gross (M) Hybrigenics SA (France; PARIS:ALHYG) ND 12/26/07 0.708S and W E8.70 10.1 E6.16 ($23.8) COMMENCED TRADING - November 2007 INITIAL OFFERINGS Company Date Filed Date Comm. Shares/Units (M) Price Shares Out (M) Gross (M) ARYx Therapeutics Inc. (ARYX) 8/31/07 11/7/07 5S $10 17.5 $50 Medgenics Inc

January | February | March | April | May | June | July | August | September | October | November | December December - 2006 Company Company Type/Product Area Terms/Details AC Immune Ltd. (Switzerland) Genentech Inc. (NYSE:DNA) Deal to develop anti-beta-amyloid antibodies for treating Alzheimer's disease and other conditions AC Immune gets up-front and research funding; it could get more than $300M in milestones for Alzheimer's and additional indications, and would get royalties

Follow-on Offerings FOLLOW-ON OFFERINGS - December 2006 Company Date Filed Date Comm. Shares/Units (M) Price Gross (M) Advanced Magnetics Inc. (AMAG) 8/11/06 12/7/06 2.103S $62 $130.4 Alnylam Pharmaceuticals Inc. (ALNY) 11/27/06 12/12/06 4.7S $22 $103.4 Arena Pharmaceuticals Inc. (ARNA) 11/28/06 12/8/06 13.225S $13.21 $174.7 Biopure Corp. (BPUR) 12/7/06 12/8/06 28.35U $0.64 $18.1 MannKind Corp. (MNKD) 11/27/06 12/7/06 23S $17.42

January | February | March | April | May | June | July | August | September | October | November | December December - 2006 Biotech Company Pharma Company Type/Product Area Terms/Details Acadia Pharmaceuticals Inc. (ACAD) Ipsen SA (France) Acadia licensed certain technology designed to add to its serotonin platform The nonexclusive license complements Acadia's existing program; Ipsen gets $0.25M up front, along with potential milestone and royalty payments Affymetrix Inc. (AFFX

January | February | March | April | May | June | July | August | September | October | November | December COMPLETED MERGERS AND ACQUISITIONS - December 2006 Company Acquired Acquired By Or Merged With Date Announced Date Completed Value (M) Terms/Details Connetics Corp. (CNCT) Stiefel Laboratories Inc. 10/23/06 12/28/06 $670 Stiefel paid $17.50 per share in cash, or $670M, for Connetics; the offer was a 62% premium to the four-week average price Elbion AG (Germany

Public Companies | Private Companies PUBLIC COMPANIES - December 2006 Company (Symbol) Type Of Financing Number Of Shares, Units Or Warrants (M) Amount Raised (US$M) Acusphere Inc. (ACUS) Registered direct offering 9.259S and 3.7W $25.5 Advancis Pharmaceutical Corp. (AVNC) Private placement of stock 6S $18 Alexza Pharmaceuticals Inc. (ALXA) Product-specific funding vehicle N/A $50 Alizyme plc (UK; LSE:AZM) Private placement of stock 18.12S $28.3

Commenced Trading COMMENCED TRADING - December 2006 INITIAL OFFERINGS Company Date Filed Date Comm. Shares/Units (M) Price Shares Out (M) Gross (M) Affymax Inc. (AFFY) 7/28/06 12/15/06 4.255S $25 14.87 $106.4 Newron Pharmaceuticals SpA (Italy; SWX:NWRN) 11/20/06 12/8/06 2.147S CHF55 5.82S CHF118 ($98.5) Pacgen Biopharmaceuticals Corp. (Canada; CDNX:PGA) 11/28/06 12/8/06 6.789S and 3.4W C$1.05 30.52 C$7.13 ($6.2) COMMENCED TRADING

Public Companies | Private Companies PUBLIC COMPANIES - December 2005 Company (Symbol) Type Of Financing Number Of Shares, Units Or Warrants (M) Amount Raised (M) Acrongenomics Inc. (OTC BB:AGNM) Private placement of stock 1S $4 Alchemia Ltd. (Australia; ASX:ACL) Private placement of stock and share purchase plan 19.6S $16.1 Amarin Corp. plc (UK; AMRN) Private placement of stock and warrants 26.1S and 9.1W $26.4 Amphion Innovations plc (AIM:AMP) Private

Follow-on Offerings FOLLOW-ON OFFERINGS - December 2005 Company Date Filed Date Comm. Shares/Units (M) Price Gross (M) Biopure Corp. (BPUR) 12/1/05 12/21/05 10.12S $0.68 $6.9 Dendreon Corp. (DNDN) 10/26/05 12/7/05 11.5S $4.50 $51.8 Medivation Inc. (OTC BB:MDVN) 10/6/05 12/15/05 5.635S $2 $11.27 OxiGene Inc. (OXGN) 12/1/05 12/15/05 7.475S $3.65 $27.3 ViroPharma Inc. (VPHM) 10/19/01 12/7/05 10.35S $16.75 $173.4 FOLLOW-ON

Commenced Trading COMMENCED TRADING - December 2005 INITIAL OFFERINGS Company Date Filed Date Comm. Shares (M) Price Shares Out (M) Gross (M) BioAlliance Pharma SA (France; Euronext: BIO) 11/17/05 12/7/05 2.256S EUR 13.30 8.27 EUR30 (US$35.5) Somaxon Pharmaceuticals Inc. (SOMX) 10/7/05 12/15/05 5S $11 18.03 $55 COMMENCED TRADING - November 2005 INITIAL OFFERINGS Company Date Filed Date Comm. Shares (M) Price Shares Out (M) Gross

January | February | March | April | May | June | July | August | September | October | November | December December - 2005 Company Company Type/Product Area Terms/Details Affymetrix Inc. (AFFX) Vita Genomics (Taiwan) Vita got nonexclusive access to Affymetrix microarray technology to develop and market in vitro diagnostics The license covers tests for alpha interferon treatment response in hepatitis patients, and for early onset and allergic asthma in infants and young children

January | February | March | April | May | June | July | August | September | October | November | December December - 2005 Biotech Company Pharma Company Type/Product Area Terms/Details Affymetrix Inc. (AFFX) Applied Biosystems Group ABG got nonexclusive rights to patents related to the use and sale of microarrays for gene expression analysis The license will be applied to the expansion of the Applied Biosystems Expression Array System; terms were not disclosed Alder Bio

January | February | March | April | May | June | July | August | September | October | November | December COMPLETED MERGERS AND ACQUISITIONS - December 2005 Company Acquired Acquired By Or Merged With Date Announced Date Completed Value (M) Terms/Details Advanced Ocular Systems Inc. Regenera Ltd. (Australia; ASX:RGA) 10/31/05 12/30/05 $31 Regenera is issuing up to 100.8M shares in the deal, retaining at least 52.2% ownership; the combined firm assumed the Advanced

FOLLOW-ON OFFERINGS - December 2004 Company Date Filed Date Comm. Shares/Units (M) Price Gross (M) Array BioPharma Inc. (ARRY) 4/22/04 12/9/04 9.2S $7.75 $71.3 Nastech Pharmaceutical Co. Inc. (NSTK) 9/30/04 12/9/04 4.25S $13.50 $57.38 NitroMed Inc. (NTMD) 11/8/04 12/8/04 3.579S $24.46 $87.5 Serologicals Corp. (SERO) 7/21/04 12/16/04 4.83S $22.80 $110.1 FOLLOW-ON OFFERINGS - November 2004 Company Date Filed Date Comm. Shares/Units (M

Commenced Trading COMMENCED TRADING - December 2004 INITIAL OFFERINGS Company Date Filed Date Comm. Shares/Units (M) Price Shares Out (M) Gross (M) Chemokine Therapeutics Corp. (Canada; TSE:CTI) 10/22/04 12/30/04 18.4S C$1 31.73 C$18.4 (US$14.9) SemBioSys Inc. (Canada; TSE:SBS) 11/29/04 12/6/04 4.025S and 2.01W C$5 12.60 C$20.1 (US$16.5) COMMENCED TRADING - November 2004 INITIAL OFFERINGS Company Date Filed Date Comm. Shares/Units (M

Public Companies | Private Companies PUBLIC COMPANIES - December 2004 Company (Symbol) Type Of Financing Number Of Shares, Units Or Warrants (M) Amount Raised (M) Abgenix Inc. (ABGX) Private placement of convertible notes N/A $225 Aradigm Corp. (ARDM) Private placement of stock and warrants 8.3S and ND $12.5 Biomira Inc. (BIOM) Private placement of stock and warrants 4.89S and 0.978W $12.57 Biopure Corp. (BPUR) Private placement of stock and warrants 40S

January | February | March | April | May | June | July | August | September | October | November | December December - 2004 Company Company Type/Product Area Terms/Details Array BioPharma Inc. (ARRY) InterMune Inc. (ITMN) InterMune got expanded rights to certain compounds under their September 2002 collaboration to discover drugs for hepatitis C Array gets a $2.5M payment, while all other terms remain the same; under a new deal, InterMune has an exclusive option through March

January | February | March | April | May | June | July | August | September | October | November | December December - 2004 Biotech Company Pharma Company Type/Product Area Terms/Details Advancis Pharmaceutical Corp. (AVNC) Par Pharmaceutical Inc. They added a pulsatile version of a combination amoxicillin/clavulanate product to their existing collaboration They were developing only an amoxicillin product; the target for both is ear infections; Par will continue to fund