They transferred this aberrant genomic sequence into embryonic stem cells and inserted these into early- stage fertilized mouse eggs, which they then implanted in the uteri of foster mothers
This dreaded disease of the blood occurs when one of the stem cells that gives rise to mature white blood cells mutates...The authors conclude that these structural features indicate that the ALL1 gene may help to regulate the development and differentiation of blood stem cells
said Tuesday that it filed a product license application (PLA) supplement with the FDA seeking approval to market Leukine for use in peripheral blood stem cell (PBSC) mobilization for transplantation...Valoree Dowell, vice president, corporate communications for Immunex, told BioWorld that 4,000 to 5,000 stem cell transplants were performed in the U.S
These scientists used hematopoietic stem cells as their targets for transduction by the ribozyme gene because of their pluripotent nature, thus potentially allowing permanent immune system reconstitution of patients...Macrophage-like cells differentiated from these stem cells in vitro and reproducibly expressed the ribozyme gene at high levels
SyStemix, which focuses mainly on developing cellular and gene therapy products based on hematopoietic stem cells and progenitors, also is collaborating with Sandoz...We remain confident that SyStemix is a leader, or the leader, technologically in stem cell- based cell therapy
in conjunction with autologous bone marrow and peripheral blood stem cell transplants for the treatment of breast cancer and lymphoma...Baxter's major competitor in the stem cell purification field is CellPro Inc., of Bothell, Wash
has started a Phase III trial of its Ceprate SC stem cell concentration system for a new indication following the FDA's decision earlier this month not to approve the cell purification procedure for autologous bone marrow transplants...The Ceprate SC system is designed to capture and purify CD34 antigen-expressing stem cells, separating them from tumor cells, before the CD34 cells are transplanted back in the patient
The FDA said CellPro's premarketing approval (PMA) application, submitted in December 1993, must be amended to satisfy various concerns about the stem cell purification system before it can be reconsidered...The Ceparate SC stem cell system targets CD34+ cells, which replicate to form cells of the blood and immune system
Reasoning that retinoic acid might induce potentially malignant embryonic stem cells to grow up and differentiate into mature white blood cells that don't proliferate out of control, clinicians have administered retinoic acid to cancer patients, with both good and bad results
Systemix Inc., of Palo Alto, Calif., has received approval from the FDA and European regulatory officials to begin its first clinical trial using purified hematopoietic stem cells to treat myeloma patients...The Phase I/II studies will analyze the treatment's safety and rapid engraftment of the stem cells, which provide all of the cells of the blood and immune system
Sperm cells develop from precursor stem-cell spermatogonia, which are "a unique and very fascinating population of cells," Brinster told BioWorld Today...The development of the spermatogonial stem-cell transplantation technique," Dym wrote, "and the possibility of manipulating the genetic makeup of the spermatogonia, provide many potential opportunities for agricultural, biological and medical research
with its Stem Cell Chemokine, BB-10010, which is being tested for its ability to mobilize blood cells into peripheral blood and as a protector of stem cells during chemotherapy
British Biotech plc completed a safety study of its Stem Cell Chemokine in healthy volunteers and has begun a study in cancer patients, the Oxford, England, company said Monday...The goal would be to harvest stem cells from the bloodstream before chemotherapy and replace then after treatment, potentially replacing bone marrow transplantation
With this construct, Miller added, "we transduced a group of CD34+ cells, which are a population of bone-marrow progenitor cells that includes stem cells
The company's findings, published in the Oct. 18 issue of Blood, show how facilitating cells permit the engraftment of purified allogeneic bone marrow stem cells without provoking graft-versus-host disease. * Cortecs International Ltd., of London, has signed a worldwide distribution agreement with Germany-based Boehringer Mannheim Diagnostics, a division of Corange Ltd, of London, for Cortecs' immuno sorbent assay
She added, "Of course, the target cell of most human gene therapy protocols is the human stem cell, and that is not efficiently infected by existing vectors
Proia and his co-workers at several NIH institutes crippled the murine Hexa gene in mouse embryonic stem cells, and raised a generation of rodents to serve as biochemical and pathological models for human Tay-Sachs
Kathleen Rinehart, Genzyme's spokeswoman, said the collaboration combines IntroGene's stem cell gene therapy with her company's experience with Gaucher's disease, which is caused by the lack of the enzyme, glucocerebrosidase (GCR...IntroGene's technology involves employing a retrovirus to introduce the GCR enzyme into stem cells in the bone marrow
They transferred this aberrant genomic sequence into embryonic stem cells and inserted these into early- stage fertilized mouse eggs, which they then implanted in the uteri of foster mothers