Centocor Inc. has filed a post-trial motion in the patent infringement suit it recently lost to Xoma Corp., asking the court to reverse at least some of the jury's verdict, a Xoma spokeswoman said on Friday. Centocor spokesman Richard Koenig declined to elaborate, but said the company may also ask U.S. District Court Judge Robert H. Schnacke to order a new trial. On Oct. 28, a San Francisco jury found that Centocor (NASDAQ:CNTO) infringed the patent covering Berkeley, Calif.- based Xoma's E5
Biogen Inc. said Friday that it has filed for an offering of 2 million shares of common stock. If the offering is completed, Biogen will have 30 million shares outstanding. Underwriters Lehman Brothers, Hambrecht & Quist Inc. and Merrill Lynch and Co. have a 300,000-share overallotment option. Biogen stock (NASDAQ:BGEN) closed down $1.50 at $42.25. The Cambridge, Mass., company's revenues are generated from worldwide sales by licensees of five products, including alpha interferon and vaccines
Bio-Technology General Corp. said Friday that it has begun Phase I clinical trials of BioTropin recombinant human growth hormone in patients with HIV. The trials will examine the potential of BioTropin to reverse or slow down wasting in HIV- infected and AIDS patients. The New York company is also conducting two additional Phase I trials of BioTropin to prevent wasting, one in cancer patients and a second in elderly patients hospitalized with hip fracture and suffering from muscle atrophy. In
David E. Robinson, former chief operating officer of Erbamont Inc., is joining Ligand Pharmaceuticals as president and chief executive officer. Robinson replaces Ligand's founder, Howard C. Birndorf, who will remain on the board as chairman emeritus. The privately held San Diego company focuses on intracellular receptor technology. Dr. Gerald A. Faich has been named chief executive officer of GHBA/PACT Inc., a St. David's, Pa., pharmaceutical industry contract research organization that
Using a gene therapy approach, tumor cells that were engineered to pump out large quantities of interleukin-4 and reimplanted in mice have prompted immune destruction of the tumor. This application of the immune messenger IL-4 suggests a new therapeutic approach to human cancer. Several companies are testing IL-4 itself in clinical trials against cancers, but the gene therapy approach provides a local, tumor-killing effect of IL-4 without the risk of toxic side effects. "The lymphokine is
TSI Corp. has acquired G.D.R.U. Ltd., a London-based provider of Phase I human clinical contract testing services, for 1.1 million shares of TSI common stock. The stock (NASDAQ:TSIN) closed Friday at $13, down 25 cents. The acquisition allows TSI to add human clinical trials to the preclinical and toxicology services it already provides. No regulatory approval or notification equivalent to an investigational new drug application (IND) in the United States is required for Phase I clinicals in
Published results of a Phase II clinical trial of ProCyte Corp.'s Iamin drug show that it decreases wound healing time by two days, from 21 days to 19 days, compared with a placebo cream. However, the 43-patient study, using patients recovering from Moh's micrographic surgery, was too small to produce statistically significant results. To gain additional efficacy information, the Kirkland, Wash., company is conducting a multicenter Phase II trial in diabetic patients suffering from chronic
Cytel Corp. and Sumitomo Pharmaceuticals Co. Ltd. have signed a five-year technology development agreement worth up to $45 million to develop drugs based on Cytel's LEC-CAM cell adhesion technology. In a separate announcement on Thursday, Cytel said it has filed for an initial public offering of 3 million shares of stock priced between $12 and $14 per share. The deal with Sumitomo covers leukocyte endothelial cell adhesion molecules to treat acute inflammatory diseases and cancer. LEC-CAMs are
WASHINGTON -- Immune Response Corp. will participate in a Nov. 12 Food and Drug Administration advisory committee meeting that will consider the use of surrogate markers -- similar to those now being used by the company -- in Phase II/III clinical trials to measure the effectiveness of AIDS vaccines. Shares of Immune Response (NASDAQ:IMNR), which is developing an AIDS therapeutic vaccine, have jumped nearly 50 percent this week. The stock closed Thursday at $59.25, up $6.13. On Tuesday
Scientists at Medarex Inc. have demonstrated that the company's bispecific antibody may inhibit infection by the AIDS virus in certain cells of the immune system. Collaborating with researchers at Dartmouth, Nathan Dinces, Medarex's vice president of operations, showed that a molecular combination of two monoclonal antibodies, which recognize HIV and a receptor on macrophages, respectively, can diminish replication of the AIDS virus. In the presence of the bispecific antibody, monocytes and
Hoffmann-La Roche Inc. has filed a new drug application for ddC that includes information on its safety and efficacy in AIDS when used alone and in combination with AZT. "We feel we have enough information to justify filing for the two indications," company spokesman Paul Oestreicher told BioWorld. He declined to provide specific data on how well the drug did in the clinic. Although he could not estimate when approval might be received, Oestreicher said that "we've been informed this would
Glycomed Inc. on Thursday said it raised $37.5 million through a secondary offering of 2.5 million shares of stock priced at $15 per share. The offering was 500,000 shares larger than the company had previously announced. The Alameda, Calif., company, which is developing pharmaceuticals based on complex carbohydrates, now has 11.7 million shares outstanding. Underwriters Montgomery Securities and Hambrecht & Quist Inc. have a 375,000-share overallotment option. In June, Glycomed (NASDAQ:GLYC
Biomira Inc. has filed for a public offering of about 4 million shares of common stock. The Canadian company, which is developing cancer diagnostics and therapeutics, would have 17.4 million shares outstanding after the offering. Canadian underwriters will be ScotiaMcLeod Inc., Burns Fry Ltd. and Richardson Greenshields of Canada Ltd. In the United States, the offering will be led by ScotiaMcLeod (U.S.A.) Inc. There is no overallotment option. Altamira Capital Corp., which holds 14.5 percent
CytRx Corp. will supply its patented adjuvant for testing of malaria vaccines in a cooperative research effort sponsored by the Centers for Disease Control, the company said Thursday. The Norcross, Ga., company (NASDAQ:CYTR) did not disclose which vaccines will be tested or when the tests will start. Adjuvants work with vaccines to boost the body's immune response. The CytRx adjuvant is a copolymer of ethylene oxide and propylene oxide. Ribi ImmunoChem Research Inc. (NASDAQ:RIBI) of Hamilton
Liposome Technology Inc. on Thursday said it has filed for a 3 million-share stock offering. If the offering is completed, the Menlo Park, Calif., company will have 16 million shares outstanding. LTIZ is developing liposome and lipid-based products to treat infectious diseases and cancer. The company has two products in Phase II clinical trials: Amphocil liposomal amphotericin B anti-fungal drug and a bronchodilator inhaled liposomal albuterol product. Underwriters Oppenheimer & Co. Inc. and
Synergen Inc. shares shot up $8.75 to $55.25 on Wednesday after the company said it would present data next week on its Phase II trial of Antril interleukin-1 receptor antagonist. The trial tested Antril in about 100 patients with sepsis syndrome, which is sepsis with clinical evidence of altered organ perfusion. Data will be presented on Nov. 7 at the American College of Chest Physicians meeting in San Francisco. Chief Executive Officer Jon Saxe predicted in September that Antril would be the
Creative BioMolecules Inc. said Wednesday that it has raised $14 million through the sale of senior preferred stock, an increase of $2.8 million from the originally planned offering. The stock was sold to American and European institutional investors, plus some of the Hopkinton, Mass., company's previous venture investors. Privately held Creative plans to do an initial public offering within six to 12 months, President and Chief Executive Charles Cohen told BioWorld. Creative focuses on two
Just four months after going public at $7.50 a share, Cor Therapeutics Inc. has raised $36.5 million in a public offering of 2 million shares priced at $18.25. Cor stock (NASDAQ:CORR) closed at $20.50, up $1.50 on Wednesday. The South San Francisco, Calif., company raised $15 million in its initial public offering during the soft offering market in June, well below its goal of $22.5 million to $27.5 million. Cor's first product, Integrelin, is in Phase I trials. The drug, which prevents
Strong revenue growth from its joint blood screening business and its ophthalmics unit helped Chiron Corp. earn $5.4 million, or 27 cents a share, on revenues of $29.9 million in the third quarter. The Emeryville, Calif., company earned about $4 million, or 23 cents, on revenues of $19.1 million in the comparable 1990 quarter. Revenues from Chiron's blood screening venture with Ortho Diagnostics Systems Inc. grew to $12.1 million in the quarter ended Sept. 30, compared with about $8 million in
Vestar Inc. announced Wednesday that AmBisome, its intravenous liposomal formulation of amphotericin B, has received approval for general sale in Mexico and a special license for sale in Italy. The drug is a broad-spectrum, anti-infective used to treat potentially fatal systemic fungal infections. AmBisome sales in Italy will be restricted to hospitals and will be based on specific therapeutic need. AmBisome was approved in December 1990 for general sale in Ireland. Elsewhere in Europe, it was
Centocor Inc. has filed a post-trial motion in the patent infringement suit it recently lost to Xoma Corp., asking the court to reverse at least some of the jury's verdict, a Xoma spokeswoman said on Friday. Centocor spokesman Richard Koenig declined to elaborate, but said the company may also ask U.S. District Court Judge Robert H. Schnacke to order a new trial. On Oct. 28, a San Francisco jury found that Centocor (NASDAQ:CNTO) infringed the patent covering Berkeley, Calif.- based Xoma's E5