January | February | March | April | May | June | July | August | September | October | November | December COMPLETED MERGERS AND ACQUISITIONS - December 2004 Company Acquired Acquired By Or Merged With Date Announced Date Completed Value (M) Terms/Details Aclara BioSciences Inc. (ACLA) ViroLogic Inc. (VLGC) 6/1/04 12/10/04 $141 ViroLogic issued 1.7M shares for each Aclara share; Aclara shareholders own about 48% of the combined compnay, and also got 1.7 contingent
January | February | March | April | May | June | July | August | September | October | November | December December - 2003 Company Company Type/Product Area Terms/Details Adherex Technologies Inc. (Canada; TSE:AHX) Cadherin Biomedical Inc. Adherex agreed to acquire noncancer cadherin-based intellectual property Adherex will pay $1M by issuing up to 2.2M shares, and a royalty rate of 2%; deal needs CBI shareholder approval Aeres Biomedical Ltd. (UK) Peregrine Pharmaceuticals
January | February | March | April | May | June | July | August | September | October | November | December December - 2003 Biotech Company Pharma Company Type/Product Area Terms/Details Actelion Ltd. (Switzerland; SWX:ATLN) Merck & Co. Inc. Worldwide alliance to discover and market new classes of renin inhibitors for cardi-renail diseases Merck is paying $10M up front and up to $262M for commercialization of the first product; Actelion could get milestones for additional products, as well
January | February | March | April | May | June | July | August | September | October | November | December | COMPLETED MERGERS AND ACQUISITIONS - December 2003 Company Acquired Acquired By Or Merged With Date Announced Date Completed Value (M) Terms/Details Aneda Ltd. (UK; formerly Edinburgh Biocomputing Systems) QBioCom Ltd. (UK) 12/22/03 12/22/03 $1.7 QBio acquired Aneda for $1.7M; specifics were not disclosed Aurora Instruments LLC (unit of Vertex Pharmaceuticals
Public Companies | Private Companies PUBLIC COMPANIES - December 2003 Company (Symbol) Type Of Financing Number Of Shares, Units Or Warrants (M) Amount Raised (M) Adherex Inc. (Canada; TSE:AHX) Convertible notes sale N/A C$1.9 (US$1.45) Affymetrix Inc. (AFFX) Private placement of convertible notes N/A $100 AnorMED Inc. (Canada; TSE:AOM) Bought-deal financing 5.2S C$25.48 (US$19.5) Arena Pharmaceuticals Inc. (ARNA) Private placement of convertible stock N/A $35 Ariad Pharmaceuticals Inc
January | February | March | April | May | June | July | August | September | October | November | December December - 2002 Company Company Type/Product Area Terms/Details Alliance Pharmaceutical Corp. (OTC BB:ALLP) Mixture Sciences Inc. Exclusive license agreement for Mixture Sciences to acquire all rights to an immunotherapy platform technology developed by Astral Inc., a subsidiary of Alliance Mixture will provide an undisclosed license fee and future royalties to alliance
January | February | March | April | May | June | July | August | September | October | November | December December - 2002 Biotech Company Pharma Company Disclosed Potential Funding (M) Details AdipoGenix Inc. Johnson & Johnson Pharmaceutical Research & Development LLC ND Agreement to develop anti-obesity compounds through use of AdipoGenix's technology to control fatty acid accumulation; AdipoGenix will screen J&J compounds and will receive an up-front payment, as well as
January | February | March | April | May | June | July | August | September | October | November | December COMPLETED MERGERS AND ACQUISITIONS - December 2002 Company Acquired Acquired By Or Merged With Date Announced Date Completed Value (M) Terms/Details InforMax Inc. (INMX) Invitrogen Corp. (IVGN) 10/15 12/12 $47 Invitrogen acquired InforMax in an all-cash transaction valued at $1.36 per share, or about $42M for the fully diluted equity COMPLETED MERGERS AND
Public Companies | Private Companies PUBLIC COMPANIES - December 2002 Company (Symbol) Type Of Financing Number Of Shares, Units Or Warrants (M) Amount Raised (M) Advanced Biotherapy Inc. (OTC BB:ADVB) Private placement of convertible subordinated notes N/A $0.5 Alkermes Inc. (ALKS) Private placement of convertible senior subordinated notes N/A $60 Alteon Inc. (AMEX:ALT) Private placement of common stock 1.7S $3 Aphton Corp. (APHT) Private placement of
FOLLOW-ON OFFERINGS - December 2002 Company Date Filed Date Comm. Shares/Units (M) Price Gross (M) No follow-on public offerings occurred in December FOLLOW-ON OFFERINGS - November 2002 Company Date Filed Date Comm. Shares/Units (M) Price Gross (M) Myriad Genetics Inc. (MYGN) 11/9/01 11/22/02 3S $19.10 $57.3 FOLLOW-ON OFFERINGS - October 2002 Company Date Filed Date Comm. Shares/Units (M) Price Gross (M) NPS Pharmaceuticals Inc. (NPSP)** 1/7 10
COMMENCED TRADING - December 2002 INITIAL OFFERINGS Company Date Filed Date Comm. Shares/Units (M) Price Shares Out (M) Gross (M) No initial public offerings commenced trading in December COMMENCED TRADING - November 2002 INITIAL OFFERINGS Company Date Filed Date Comm. Shares/Units (M) Price Shares Out (M) Gross (M) No initial public offerings commenced trading in November COMMENCED TRADING - October 2002 INITIAL OFFERINGS Company Date Filed
January | February | March | April | May | June | July | August | September | October | November | December December - 2001 Company Company Type/Product Area Terms/Details Atugen AG (Germany) Oxford GlycoSciences plc (UK; LSE:OGS; OGSI) Collaboration to validate high-priority disease-associated genetic targets of interest to OGS OGS will provide novel high-priority drug targets to Atugen to enable validation in specific cell lines and in animal models of human diseases
January | February | March | April | May | June | July | August | September | October | November | December December - 2001 Biotech Company Pharma Company Disclosed Potential Funding (M) Details Actelion Ltd. (Switzerland; SWX:ATLN) Neopharm Ltd. (Israel) ND Exclusive licensing agreement in which Neopharm will be responsible for the registration, marketing and reimbursement of Tracleer in Israel Actelion Ltd. (Switzerland; SWX:ATLN) Nova Factor Inc. (subsidiary of Accredo Health Inc.) and
January | February | March | April | May | June | July | August | September | October | November | December COMPLETED MERGERS AND ACQUISITIONS - December 2001 Company Acquired Acquired By Or Merged With Date Announced Date Completed Value (M) Terms/Details Asys Hitech GmbH (Austria) Harvard Bioscience Inc. (HBIO) 12/7 12/7 ND Harvard Bioscience acquired Asys, which should add about $1.5M to $2M in revenue for the company in 2002 Atlantic Stem Cells Inc
Public Companies | Private Companies PUBLIC COMPANIES - December 2001 Company (Symbol) Type Of Financing Number Of Shares, Units Or Warrants (M) Amount Raised (M) Aradigm Corp. (ARDM) Private placement of Series A convertible preferred stock 2S $48.4 Axonyx Inc. (AXYX) Private placement of common stock and warrants W for 0.98S $6.4 Bioject Medical Technologies Inc. (BJCT) Private placement of common stock 0.35S $3.85 Cephalon Inc. (CEPH) Private placement
December | November | October | September | August | July | June | May | April | March | February | January December - 2000 Company Company Type/Product Area Terms/Details Amersham Pharmacia Biotech Ltd. BioImage AS (Denmark) Collaboration to commercialize a cell-based screening technology based on green fluorescent protein Amersham Pharmacia gains an exclusive license to BioImage's European patent portfolio on GFP Amgen Inc. (AMGN) Oxford Assymetry International plc (UK
January | February | March | April | May | June | July | August | September | October | November | December COMPLETED MERGERS AND ACQUISITIONS - December 2004 Company Acquired Acquired By Or Merged With Date Announced Date Completed Value (M) Terms/Details Aclara BioSciences Inc. (ACLA) ViroLogic Inc. (VLGC) 6/1/04 12/10/04 $141 ViroLogic issued 1.7M shares for each Aclara share; Aclara shareholders own about 48% of the combined compnay, and also got 1.7 contingent