Intellect Neurosciences Inc., of New York, said it started in vivo proof-of-concept studies for its monoclonal antibody, TauC3, in a preclinical model of Alzheimer's disease

Bone Medical Ltd., of Bentley, Australia, reported that its product candidate BN006 was found in a proof-of-concept study to reduce inflammation in a model of collagen antibody-induced arthritis

Unlike university research centers, which tend to operate as silos seeking to license or spin out home-grown discoveries, the alliance members are fully integrated translational medicine centers capable of advancing projects from discovery through preclinical screening to proof-of-concept studies

While TransCelerate is seeking to improve the speed and quality of clinical trials by identifying and solving common bottlenecks in trial design and execution, the alliance hopes to advance more drug discovery projects through proof-of-concept by strengthening the international academic and not-for-profit drug development and commercialization network. (See BioWorld Today, Sept. 26, 2012.) Members of the alliance also have complementary strengths

Bone Medical Ltd., of Bentley, Australia, reported that its product candidate BN006 was found in a proof-of-concept study to reduce inflammation in a model of collagen antibody-induced arthritis

The LDC will identify compounds and take the most promising into further drug discovery by optimizing them into pharmaceuticals leads with in vivo proof of concept

A Phase I proof-of-concept study could recruit ASIA-A, B and C patients and then "be data-driven in terms of how we refine the patient population going forward" into pivotal trials, he said

Anthera is planning to begin enrollment in a Phase II proof-of-concept trial (BRIGHT-SC) in IgA nephropathy in 2013

The LDC will identify compounds and take the most promising into further drug discovery by optimizing them into pharmaceuticals leads with in vivo proof of concept

Stratatech Corp., of Madison, Wis., reported top-line data from a proof-of-concept trial testing StrataGraft, a universal human skin substitute in development for treating severe burns

RSV Project: New Mechanism, Viaskin Delivery The RSV-NanoViaskin project with INRA aims to demonstrate preclinical proof of concept for a new model of pediatric RSV vaccine during a 30-month study in animal models

Versartis is expecting proof-of-concept efficacy results from VERTICAL in 2014, at which time it will prepare for launch of a Phase III trial

Already, that has "allowed for a clinical proof of concept for selective BCL-2 inhibition

For us it was a very good clinical proof of concept," Mark Krul, the company's other joint managing director told BioWorld International

Addex Therapeutics SA, of Geneva, said it achieved preclinical proof of concept for its lead GABA-B receptor-positive allosteric modulator compound, ADX71441, in a model of Charcot-Marie-Tooth1A, a rare hereditary motor and sensory demyelinating peripheral neuropathy caused by an intrachromosomal duplication and consecutive toxic overexpression of the PMP22 gene on chromosome 17

Under the terms, Daiichi will pay Amplimmune an undisclosed option fee and provide more than $50 million to reimburse past and planned R&D costs, including funding for future development through a Phase II proof-of-concept study

Addex Therapeutics SA, of Geneva, said it achieved preclinical proof of concept for its lead GABA-B receptor-positive allosteric modulator compound, ADX71441, in a model of Charcot-Marie-Tooth1A, a rare hereditary motor and sensory demyelinating peripheral neuropathy caused by an intrachromosomal duplication and consecutive toxic overexpression of the PMP22 gene on chromosome 17

For us it was a very good clinical proof of concept," Mark Krul, the company's other joint managing director told BioWorld Today

proof of concept for the first DuoBody candidate 12/12/12 Halozyme Therapeutics Inc. (San Diego) Roche AG (Basel, Switzerland) $4 For the submission of a line extension application to the European Medicines Agency for a subcutaneous formulation of MabThera (rituximab) for non-Hodgkin's lymphoma 12/11/12 Millennium: The Takeda Oncology Company and Takeda Pharmaceutical Co