December | November | October | September | August | July | June | May | April | March | February | January COMPLETED MERGERS AND ACQUISITIONS - December 2000 Company Acquired Acquired By Or Merged With Date Announced Date Completed Value (M) Terms/Details Agritope Inc. (AGTO) Exelixis Inc. (EXEL) 9/10 12/8 $31 Agritope stockholders will receive about 1.7M shares of Exelixis stock Bartels Inc. (unit of Intracel Corp.) Trinity Biotech plc (Ireland; TRIB) 12/18 12

Public Companies | Private Companies PUBLIC COMPANIES - December 2000 Company (Symbol) Type Of Financing Number Of Shares, Units Or Warrants (M) Amount Raised (M) Advanced Biotherapy Inc. (OTC BB:ADVB) Private placement of convertible subordinated debt ND $1.5 AltaRex Corp. (Canada; TSE:AXO; ALRXF) Private placement of common stock 3.5S $5.14 Aradigm Corp. (ARDM) Private placement of common stock 0.115S $2.2 Aviron Inc. (AVIR) Private placement of common

FOLLOW-ON OFFERINGS - December 2000 Company Date Filed Date Comm. Shares/Units (M) Price Gross (M) Bone Care International Inc. (BCII) 9/12 12/11 2.3S $16 $36.8 ICOS Corp. (ICOS) 10/11 12/14 5.175S $37 $191.48 Neurocrine Biosciences Inc. (NBIX) 10/4 12/6 3S $30 $90 North American Scientific Inc. (NASI) N/A 12/20 2.695 $17.875 $48.2 Oxford Glycosciences plc (UK; OGSI; LSE:OGS) 11/13 12/7 11.77S 12.75 (US$18.36) 150 (US$216) FOLLOW-ON

COMMENCED TRADING - December 2000 INITIAL OFFERINGS Company Date Filed Date Comm. Shares/Units (M) Price Shares Out (M) Gross (M) Genvec Inc. (GNVC) 10/5 12/12 4S $9.50 17.75 $38 Harvard Bioscience Inc. (HBIO) 9/18 12/7 6.25S $8 24.8 $50 Nexia Biotechnologies Inc. (Canada; TSE:NXB) 10/20 12/19 5.3S C$8 22.5 C$42.4M (US$27.6M) COMMENCED TRADING - November 2000 INITIAL OFFERINGS Company Date Filed Date Comm. Shares/Units (M

COMPLETED IN 1999 Company (Symbol) Offer Date Shares/ Units (M) Price Gross ($M) Shares Out (M) Albany Molecular Research Inc. (AMRI) 2/3 2.82S $20.00 $56.3 12.8 AnorMED Inc. (TSE:AOM) 2/25 5.2S $4.04 $20.8 20.5 Invitrogen Corp. (IVGN) 2/26 3.525S $15.00 $52.875 12.6 MorphoSys AG (Neuer Mkt:MORG) 3/9 1.03S $27.25 $28 3.6 Immtech International (IMMT) 4/27 1.15S $10.00 $11.5 5.05 United Therapeutics Corp. (UTHR) 6/17 5.175S $12.00 $62.1 15.9 VaxGen Inc. (VXGN) 6/30 3.56S $13.00 $46.3 11.3

Company Company Type/Product Area Terms/Details (Month) Abgenix Inc. AVI BioPharma Inc. License and option agreement; use of Abgenix's XenoMouse technology to develop fully human antibodies to human chorionic gonadotropin (hCG) for treating cancer AVI licensed technology to generate product candidates; AVI responsible for product development, manufacturing and commercialization; Abgenix gets certain payments, milestones and royalties (1/99) Abgenix Inc. Genentech Inc. New, multi

Biotech Co. Pharma Co. Type/Product Area Amount Terms/Details (Date) Abgenix Inc. BASF Bioresearch (unit of BASF AG:Germany) Research collaboration; BASF will utilize Abgenix's XenoMouse technology to develop fully human antibodies to an undisclosed antigen target ND Abgenix receives up-front payment and could receive additional fees and milestones, plus royalties on future product sales (3/99) Abgenix Inc. Japan Tobacco Inc. Clinical trial support related to marketing

COMPLETED MERGERS AND ACQUISITIONS - 1999 Company Acquired Acquired By Or Merged With Date Announced Date Completed Value (M) Terms/Details Acacia Biosciences Inc. Rosetta Inpharmatics Inc. Jan-99 Feb-99 ND Rosetta acquired Acacia in an all-stock transaction; details ND Advanced Inhalation Research Inc. Alkermes Inc. Feb-99 Feb-99 114 Alkermes issued 3.68M shares of common stock to buy Advanced Inhalation Agouron Pharmaceuticals Inc. Warner-Lambert Co

Public Companies | Private Companies PUBLIC COMPANIES - 1999 Company Type Of Financing Number Of Shares, Units Or Warrants (M) Amount Raised (M) Aastrom Biosciences Inc. Convertible preferred stock and warrants 3,000 preferred shares; warrants for 0.3M shares of common stock 3 Abgenix Inc. Private placement of common stock 1.8S 75 Access Pharmaceuticals Inc. Private placement of common stock 1.5S 3 Advanced Viral Research Corp. Private placement of convertible debentures