Wilson observed that 3TC already is being tested in combination with protease inhibitors, which are among the newest HIV drugs poised to enter the market
It also cleared the first protease inhibitor to treat HIV disease when it recommended accelerated approval for Saquinavir in combination with nucleoside analogs. (See BioWorld Today, Nov. 7, 8, 1995, p. 1.) n -- Michele L. Robinson Washington Editor (c) 1997 American Health Consultants
The company also is developing protease inhibitors to treat coagulation disorders...He added that Astra Merck may be interested in developing other Lexin protease inhibitors
Genentech Amyloid protease WO 95/23860 S. San Francisco inhibitor Serine protease inhibitor that inhibits Factor VIIa and plasmin derived from amyloid a-protein precursor inhibitor
No protease inhibitor has yet been approved by the FDA for AIDS...Protease inhibitors, which attack HIV at the end of its replication cycle in an attempt to stop its proliferation, are considered less toxic than nucleoside analogs, which target the virus earlier in the cycle
study "tells us that Agouron's protease inhibitor is very active as an anti-retroviral agent, and its safety profile suggests it will be an excellent component in combination therapy
as a result of the decision to take Agouron's protease inhibitor, AG1343, into Phase II/III studies...While Agouron's development timeline is behind some of its competitors in the protease inhibitor field, its second-generation product is expected to have a better safety profile
Abbott Laboratories, Abbott Park, Ill., on Aug. 31, 1995 announced a compassionate use program for Ritonavir slated to start in January 1996 for its protease inhibitor drug for treating AIDS and HIV
In November 1994, Arris signed a potential $70 million alliance with Germany-based Bayer AG to find other protease inhibitors for treatment of inflammatory diseases...In the Pharmacia deal targeting serine protease inhibitors, Walker said Arris already has identified three compounds that inhibit thrombin, Factor Xa and Factor VIIa, all of which are involved in the blood clotting cascade
The protease inhibitors are designed to block replication of HIV and are considered less toxic than the currently available nucleoside analogs, AZT and ddc, which attack the virus at an earlier stage in the replication cycle...A second generation protease inhibitor in an earlier stage of development is being tested by Vertex Pharmaceuticals Inc., of Cambridge, Mass., in association with Glaxo Wellcome
In that way, these drugs or drug candidates, of course, are quite different from the usual class of anti-AIDS therapeutics _ AZT, protease inhibitors and the like
The company also will be looking to develop new partnership opportunities for orally bioavailable elastase inhibitors, protease inhibitors and second- generation bradykinin antagonists
Sunday and Monday, at the American Chemical Society meeting in Chicago, a poster in the Medicinal Chemistry Division reported on "Mechanism-Based Cysteine Protease Inhibitors...It defined these small-molecule protease inhibitors as "compounds designed to restore the natural equilibrium of proteases
Agouron's proposed stock sale also comes on the heels of the release last month of preliminary Phase II study data showing significant anti-HIV effects from the La Jolla, Calif.-based company's orally administered protease inhibitor, AG1343
Results of a small Phase II study presented Tuesday showed significant anti-HIV effects from Agouron Pharmaceuticals Inc.'s protease inhibitor, AG1343...Agouron is collaborating on development of the protease inhibitor with Japan Tobacco Inc., of Tokyo, which already has paid Agouron $6 million and is scheduled to pay another $24 million upon satisfactory results from the Phase II pilot study
A future project, Peisach suggested, might involve a more expensive and potentially useful enzyme, namely, "an HIV protease inhibitor...He now said, "We've got this HIV protease inhibitor done, much the same as the elastase one, and submitted it for publication in a different journal
of Serine WO 95/28422 Philadelphia protease inhibitor Methods for producing a recombinant serine protease inhibitor