Omeros Corp., of Seattle, said its Cellular Redistribution Assay technology identified small molecules that interact with a Class B G protein-coupled receptor

The Cangenix unit, which has just four employees, will remain at its present base in Canterbury, but it will become part of the Harlow, UK-based Argenta organization, which focuses on small-molecule drug discovery...It can assist in a smart way (via computer modeling) the discovery and optimization of new small-molecule drugs," De Kerpel noted

The Cangenix unit, which has just four employees, will remain at its present base in Canterbury, but it will become part of the Harlow, UK-based Argenta organization, which focuses on small-molecule drug discovery...It can assist in a smart way (via computer modeling) the discovery and optimization of new small-molecule drugs," De Kerpel noted

Priaxon AG, of Munich, Germany, said it inked a deal with GlaxoSmithKline plc, of London, to research and develop small-molecule modulators of protein-protein interactions

The Cangenix unit, which has just four employees, will remain at its present base in Canterbury, but it will become part of the Harlow, UK-based Argenta organization, which focuses on small-molecule drug discovery...It can assist in a smart way (via computer modeling) the discovery and optimization of new small-molecule drugs," De Kerpel noted

Another company in the KDev portfolio that has reached Phase II trials is Axelar AB, which is developing a small-molecule inhibitor of insulin-growth factor receptor, which, unlike many other small-molecule inhibitors, does not act on the related insulin receptor

Hoping to beef up its arsenal against drug-resistant bacteria, the FDA is taking the first steps to blaze a new approval shortcut for drugs, both small molecules and biologics, that narrowly focus on serious or life-threatening diseases in which there's an unmet need

small molecule Castration-resistant prostate cancer Treated the first patient in the Phase II ARMOR2 study

small molecule inhibitor of the PLK1 protein Acute myeloid leukemia Phase II data showed higher rates of objective response and a trend for longer median event-free survival when given in combination with low-dose cytarabine vs

Highly selective small molecules are invaluable tools for studying and unlocking disease biology," he said

The small-molecule phosphodiesterase 4 inhibitor hit primary and major secondary endpoints, with improved safety and tolerability over previous psoriasis studies

Unlike small-molecule targeted drugs, which interfere with the action of a specific protein to create a therapeutic effect, Accurins bind to a specific surface protein to concentrate the drug at the sites where it is needed

That forms the basis for using fragment-based approaches to discover new small-molecule leads

Those have been identified by a "network pharmacology" approach, based on identifying several points of intervention in disease networks. (See BioWorld International, Feb. 15, 2012.) Several other small-molecule and biologic-based approaches to targeting Abeta production have foundered in recent years for reasons that are not yet fully understood, but which may be linked to patients' disease status

Priaxon AG, of Munich, Germany, said it inked a deal with GlaxoSmithKline plc, of London, to research and develop small-molecule modulators of protein-protein interactions

That forms the basis for using fragment-based approaches to discover new small-molecule leads

EPI-743 is a small-molecule cofactor for NADPH quinone oxidase 1...ETC-1002 is a once-daily, small-molecule therapy that has been shown to be liver-selective for activation of AMP kinase and inhibition of ATP citrate lyase

The small-molecule chemotherapeutic received orphan drug designation in the U.S