Warning: The table 'watchdog' is full query: INSERT INTO watchdog (uid, type, message, variables, severity, link, location, referer, hostname, timestamp) VALUES (0, 'php', '%message in %file on line %line.', 'a:4:{s:6:\"%error\";s:12:\"user warning\";s:8:\"%message\";s:206:\"Table './bioworld/profile_values' is marked as crashed and should be repaired\nquery: SELECT f.name, f.type, v.value FROM profile_fields f INNER JOIN profile_values v ON f.fid = v.fid WHERE uid = 0\";s:5:\"%file\";s:58:\"/data/html/www_bioworld_com/modules/profile/profile.module\";s:5:\"%line\";i:229;}', 3, '', 'http://www.bioworld.com/content/%E2%80%98shuttle%E2%80%99-gets-large-molecules-across-blood-brain-barrier-0', '', '50.19.171.113', 1417186166) in /data/html/www_bioworld_com/includes/database.mysql.inc on line 135 Warning: The table 'watchdog' is full query: INSERT INTO watchdog (uid, type, message, variables, severity, link, location, referer, hostname, timestamp) VALUES (0, 'php', '%message in %file on line %line.', 'a:4:{s:6:\"%error\";s:12:\"user warning\";s:8:\"%message\";s:162:\"Table './bioworld/profile_values' is marked as crashed and should be repaired\nquery: SELECT pv.value FROM profile_values pv WHERE pv.uid=0 AND pv.fid=13\";s:5:\"%file\";s:77:\"/data/html/www_bioworld_com/sites/all/modules/custom/tracking/tracking.module\";s:5:\"%line\";i:92;}', 3, '', 'http://www.bioworld.com/content/%E2%80%98shuttle%E2%80%99-gets-large-molecules-across-blood-brain-barrier-0', '', '50.19.171.113', 1417186166) in /data/html/www_bioworld_com/includes/database.mysql.inc on line 135 Warning: The table 'watchdog' is full query: INSERT INTO watchdog (uid, type, message, variables, severity, link, location, referer, hostname, timestamp) VALUES (0, 'php', '%message in %file on line %line.', 'a:4:{s:6:\"%error\";s:12:\"user warning\";s:8:\"%message\";s:207:\"Table './bioworld/cache_content' is marked as crashed and should be repaired\nquery: SELECT data, created, headers, expire, serialized FROM cache_content WHERE cid = 'content_type_info:en'\";s:5:\"%file\";s:46:\"/data/html/www_bioworld_com/includes/cache.inc\";s:5:\"%line\";i:27;}', 3, '', 'http://www.bioworld.com/content/%E2%80%98shuttle%E2%80%99-gets-large-molecules-across-blood-brain-barrier-0', '', '50.19.171.113', 1417186166) in /data/html/www_bioworld_com/includes/database.mysql.inc on line 135 Warning: The table 'watchdog' is full query: INSERT INTO watchdog (uid, type, message, variables, severity, link, location, referer, hostname, timestamp) VALUES (0, 'php', '%message in %file on line %line.', 'a:4:{s:6:\"%error\";s:12:\"user warning\";s:8:\"%message\";s:1107980:\"Table './bioworld/cache_content' is marked as crashed and should be repaired\nquery: UPDATE cache_content SET data = 'a:4:{s:11:\\"field types\\";a:12:{s:13:\\"nodereference\\";a:4:{s:5:\\"label\\";s:14:\\"Node reference\\";s:11:\\"description\\";s:51:\\"Store the ID of a related node as an integer value.\\";s:6:\\"module\\";s:13:\\"nodereference\\";s:10:\\"formatters\\";a:4:{s:7:\\"default\\";a:4:{s:5:\\"label\\";s:12:\\"Title (link in /data/html/www_bioworld_com/includes/database.mysql.inc on line 135 Warning: The table 'watchdog' is full query: INSERT INTO watchdog (uid, type, message, variables, severity, link, location, referer, hostname, timestamp) VALUES (0, 'php', '%message in %file on line %line.', 'a:4:{s:6:\"%error\";s:12:\"user warning\";s:8:\"%message\";s:208:\"Table './bioworld/cache_content' is marked as crashed and should be repaired\nquery: SELECT data, created, headers, expire, serialized FROM cache_content WHERE cid = 'content:371402:371402'\";s:5:\"%file\";s:46:\"/data/html/www_bioworld_com/includes/cache.inc\";s:5:\"%line\";i:27;}', 3, '', 'http://www.bioworld.com/content/%E2%80%98shuttle%E2%80%99-gets-large-molecules-across-blood-brain-barrier-0', '', '50.19.171.113', 1417186166) in /data/html/www_bioworld_com/includes/database.mysql.inc on line 135 Warning: The table 'watchdog' is full query: INSERT INTO watchdog (uid, type, message, variables, severity, link, location, referer, hostname, timestamp) VALUES (0, 'php', '%message in %file on line %line.', 'a:4:{s:6:\"%error\";s:12:\"user warning\";s:8:\"%message\";s:706:\"Table './bioworld/cache_content' is marked as crashed and should be repaired\nquery: UPDATE cache_content SET data = 'a:4:{s:27:\\"field_featured_science_news\\";a:1:{i:0;a:1:{s:5:\\"value\\";s:1:\\"0\\";}}s:12:\\"field_kicker\\";a:1:{i:0;a:1:{s:5:\\"value\\";s:15:\\"The Double Bind\\";}}s:22:\\"field_feed_author_name\\";a:1:{i:0;a:1:{s:5:\\"value\\";s:14:\\"Anette Breindl\\";}}s:18:\\"field_author_title\\";a:1:{i:0;a:1:{s:5:\\"value\\";s:14:\\&a in /data/html/www_bioworld_com/includes/database.mysql.inc on line 135 Warning: The table 'watchdog' is full query: INSERT INTO watchdog (uid, type, message, variables, severity, link, location, referer, hostname, timestamp) VALUES (0, 'php', '%message in %file on line %line.', 'a:4:{s:6:\"%error\";s:12:\"user warning\";s:8:\"%message\";s:205:\"Table './bioworld/cache_content' is marked as crashed and should be repaired\nquery: SELECT data, created, headers, expire, serialized FROM cache_content WHERE cid = 'fieldgroup_data:en'\";s:5:\"%file\";s:46:\"/data/html/www_bioworld_com/includes/cache.inc\";s:5:\"%line\";i:27;}', 3, '', 'http://www.bioworld.com/content/%E2%80%98shuttle%E2%80%99-gets-large-molecules-across-blood-brain-barrier-0', '', '50.19.171.113', 1417186166) in /data/html/www_bioworld_com/includes/database.mysql.inc on line 135 Warning: The table 'watchdog' is full query: INSERT INTO watchdog (uid, type, message, variables, severity, link, location, referer, hostname, timestamp) VALUES (0, 'php', '%message in %file on line %line.', 'a:4:{s:6:\"%error\";s:12:\"user warning\";s:8:\"%message\";s:86520:\"Table './bioworld/cache_content' is marked as crashed and should be repaired\nquery: UPDATE cache_content SET data = 'a:2:{s:6:\\"groups\\";a:1:{s:7:\\"bioscan\\";a:1:{s:13:\\"group_bioscan\\";a:7:{s:10:\\"group_type\\";s:8:\\"standard\\";s:9:\\"type_name\\";s:7:\\"bioscan\\";s:10:\\"group_name\\";s:13:\\"group_bioscan\\";s:5:\\"label\\";s:19:\\"Bioscan Information\\";s:8:\\"settings\\";a:2:{s:4:\\"form\\";a: in /data/html/www_bioworld_com/includes/database.mysql.inc on line 135 Warning: The table 'watchdog' is full query: INSERT INTO watchdog (uid, type, message, variables, severity, link, location, referer, hostname, timestamp) VALUES (0, 'php', '%message in %file on line %line.', 'a:4:{s:6:\"%error\";s:12:\"user warning\";s:8:\"%message\";s:206:\"Table './bioworld/profile_values' is marked as crashed and should be repaired\nquery: SELECT f.name, f.type, v.value FROM profile_fields f INNER JOIN profile_values v ON f.fid = v.fid WHERE uid = 0\";s:5:\"%file\";s:58:\"/data/html/www_bioworld_com/modules/profile/profile.module\";s:5:\"%line\";i:229;}', 3, '', 'http://www.bioworld.com/content/%E2%80%98shuttle%E2%80%99-gets-large-molecules-across-blood-brain-barrier-0', '', '50.19.171.113', 1417186167) in /data/html/www_bioworld_com/includes/database.mysql.inc on line 135 ‘Shuttle’ gets large molecules across blood-brain barrier | BioWorld

Login to Your Account



The Double Bind

‘Shuttle’ gets large molecules across blood-brain barrier

By Anette Breindl
Science Editor

Wednesday, January 8, 2014
Scientists from Roche Pharma Early Research and Development (pRED) have developed a method to deliver large-molecule therapeutics across the blood-brain barrier with much greater efficiency. With their method, which they have called Brain Shuttle, “we have now opened up the druggable space in the brain,” Roche pRED head of neuroscience, ophthalmology and rare diseases, Luca Santarelli, told BioWorld Today. The blood-brain barrier keeps most large molecules (and any number of small ones, too) from crossing out of the circulation and into the brain.

To continue reading subscribe now to Science News

Learn More about Science News

Already a subscriber? Sign In or Buy now to activate your subscription