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AD Enzyme Also Controls Normal Muscle Development

By Sharon Kingman
Staff Writer

Tuesday, June 25, 2013
LONDON – Treating Alzheimer's disease (AD) by inhibiting a key enzyme that helps to generate amyloid-beta peptide sounded like a good strategy – but evidence is continuing to build, showing that the enzyme also has important other functions in the body. The latest fly in the ointment is the discovery that the enzyme, Bace1, also controls the development of muscle spindles. The same study showed that mice that lack Bace1, or are treated with compounds that inhibit it, show movement abnormalities.

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