Anti-Aging Family Member Sirt2 Sex-Specific Tumor Suppressor

Researchers from the National Institutes of Health have shown that Sirt2, a member of the anti-aging sirtuin family, functions as a tumor suppressor – and that it does so for different tumor types for males and females. In mice, knocking out Sirt2 led to high rates of breast tumors in females, while about a quarter of male mice (but only one out of 26 female mice) lacing the gene developed liver cancer.