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Missing Cancer-Aging Link?

Anti-Aging Family Member Sirt2 Sex-Specific Tumor Suppressor

By Anette Breindl

Friday, October 21, 2011
Researchers from the National Institutes of Health have shown that Sirt2, a member of the anti-aging sirtuin family, functions as a tumor suppressor – and that it does so for different tumor types for males and females. In mice, knocking out Sirt2 led to high rates of breast tumors in females, while about a quarter of male mice (but only one out of 26 female mice) lacing the gene developed liver cancer.

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