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Swine fever

Best-laid plans of mice and men derailed by pigs

By Anette Breindl
Senior Science Editor

Wednesday, November 15, 2017

Therapeutic administration of interleukin-10 (IL-10) into the cerebrospinal fluid through intrathecal gene therapy caused fatal meningitis in swine, an unexpected toxicity that had not been seen in multiple rodent experiments.

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