I. MODIFIED AGREEMENTS

Biotech Co.*
(Country;Symbol)

Pharma Co.
(Country)

Change from original
agreement

Terms/Details (Details)


Cytokinetics
Inc.
(CYTK)

GlaxoSmithKline  plc (UK)

Amended agreement provides Cytokinetics an expanded role in development of SB-743921

Cytokinetics will lead and fund development in certain hematological cancers and  is entitled to additional milestone payments; GSK has an option to take over responsibility in those indications (9/27)

 

Epigenomics
AG
Germany;
FSE:ECX)

Roche Diagnostics

They extended a deal  covering the development of five cancer diagnostic tests

The R&D part of the collaboration was extended at least six months with the option to expand the deal; terms were not disclosed (9/30)

 

Imcor
Pharmaceutical
Co.
(PK:ICPH)
and
Alliance
Pharmaceutical
Corp.
(OTC BB:ALLP)

GE Healthcare (UK)

They resolved disputed patent claims covering ultrasound contrast agents

GE Healthcare will pay $1M to Imcor and $200,000 to Alliance in license fees; all parties granted the others nonexclusive, royalty-free cross-licenses with the right to sublicense their respective ultrasound contrast agents (9/22)

 

MedImmune
Inc.
(MEDI)

Abbott Laboratories

They amended U.S. co-promotion agreement on Synagis, a product for treating respiratory syncytial virus

MedImmune will take full responsibility for product sales in the U.S. after June 2006; Abbott is entitled to a portion of sales and potential milestone payments (8/31)

 

Prima Biomed Ltd. (Australia; ASX:PRR)

AstraZeneca plc (UK)

They extended research deal on Fc receptor technology until June 30

The deal from October 2004 was made with Prima Biomed subsidiary Arthron Pty. Ltd.; AstraZeneca retains an option to license the technology (9/27)

 

II. TERMINATED AGREEMENTS

BioTie
Therapies Oyj
(Finland; HSE:BTH1V)

Sanofi-Aventis Group (France)

Sanofi did not renew option agreement in deal to develop a oral heparin-like product

BioTie plans to continue the recombinant heparin program with a new development partner (10/17)

 

Flamel
Technologies
SA
(France;

TAP Pharmaceutical  Products Inc.

TAP terminated a deal to use Flamel's Micropump technology in the delivery of lansoprazole

The compound is the active ingredient in TAP's Prevacid; TAP intends to move forward with a different formulation (9/5)

 

Praecis
Pharmaceuticals
Inc.
(PRCS)

Schering AG (Germany)

Schering exercised its right to terminate agreement covering Praecis' Plenaxis product

Schering cited the product not having received marketing authorization in Germany with a requisite label by June 30 as reason for ending the deal (9/28)


Notes:

# The information in the chart does not cover agreements between biotech companies or agricultural agreements.

* Private companies are indicated with an asterisk.

Unless otherwise noted, stock symbols listed are on the Nasdaq market.

ASX = Australian Stock Exchange; FSE = Frankfurt Stock Exchange; HSE = Helsinki Stock Exchange; OTC BB = Over-the-Counter Bulletin Board; PK = Pink Sheets.