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Cancer Kinase Links Prions with Alzheimer's Disease

By Anette Breindl
Science Editor

Tuesday, August 20, 2013
French researchers identified new links between prion protein and Alzheimer's disease and have shown that by inhibiting the kinase PDK1, they were able to independently slow the disease progression in both prion disease and Alzheimer's disease in mice. To be fair, the specific drug that the team used in their work, BX912, is too toxic to be a clinical candidate itself. It was so toxic, in fact, that it killed the Alzheimer's mice, making it impossible to see whether the compound improved survival.

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