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Cell cycle has need for speed in iPS cell reprogramming
By Anette Breindl
Monday, February 3, 2014
Last week, the news that exposing mature cells to stressful environments such as low pH can induce a stem cell-like state was greeted with much excitement, as stimulus-triggered acquisition of pluripotency cells (STAP cells) joined embryonic stem cells (ES cells) and induced pluripotent stem cells (iPS cells) as a cell type that might ultimately provide materials for autologous cell transplants. But iPS cells, too, made progress last week. A study published in the Jan. 30, 2014, issue of Cell showed that the likelihood of blood-forming cells transforming into iPS cells when they were treated with reprogramming factors could be increased by speeding up their cell cycle.
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