• Idera Pharmaceuticals Inc., of Cambridge, Mass., said it treated the first patient in a Phase II trial of IMO-3100, its lead Toll-like receptor (TLR) 7 and TLR9 inhibitor, in moderate to severe plaque psoriasis. The study is designed to enroll 45 patients randomized to receive IMO-3100 at one of two doses or placebo, administered by subcutaneous injection once weekly for four weeks.