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Nongenetic Data Yield Risk Genes

Complex Diseases Can Start in Mendelian Genes

By Anette Breindl
Science Editor

Friday, September 27, 2013
Figuring out the contribution of any gene to complex disorders is a murky fishing expedition, done in waters muddied by the interaction of the gene in question with other genes and environmental influences. As a result, identifying genetic contributions to complex disorders has been slow going even when very large groups have been sequenced. Recently, scientists at the University of Chicago described a new way to identify risk genes that did not, at least initially, rely on sequencing the genes in question, or any sequencing at all.

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