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DOT’s No Fair? Epizyme Reeling; Phase I ‘Panic’ on Wall Street

By Randy Osborne
Staff Writer

Thursday, November 14, 2013
Epizyme Inc.’s Phase I study, designed mainly to determine the safety of EPZ-5676, an inhibitor of the DOT1L histone methyltransferase (HMT) for the treatment of acute leukemia with rearrangements in the mixed lineage leukemia gene (MLL-r), ended up showing treatment effects in four of eight patients.

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