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Think PINK

Drug Gets Kinase Back to Work in Parkinson's Disease

By Anette Breindl
Science Editor

Monday, August 19, 2013
As far as targeting kinases goes, inhibition is the only game in town. But that is not because there's no need for activators. Kinases that no longer work like they should play a role in diseases including diabetes, cancer and Parkinson's disease. In the latter case, the kinase in question is PINK1. PINK1 is found in mitochondria, where its functioning is important to keep them healthy. Mutations in the PINK1 gene that reduce the enzyme's activity can lead to early onset Parkinson's disease.

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