Dystrophin is newly identified tumor suppressor
What does the loss of dystrophin lead to? Well, yeah, dystrophy. And, sometimes, metastatic cancer. That's the conclusion of a paper published in the May 4, 2014, issue of Nature Genetics, which showed that in certain types of cancer, loss of the dystrophin protein appeared to be the last in a series of steps that had tumors turning metastatic. "In these myogenic tumors" – gastrointestinal stromal tumors (GIST), rhabdomyosarcoma and leiomyosarcoma, all of which arise from muscle cells – the work "very convincingly establishes dystrophin as a tumor suppressor," corresponding author Jonathan Fletcher, of Brigham and Women's Hospital, told BioWorld Today.
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