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Egg cell totipotency proteins enhance reprogramming

By Anette Breindl
Science Editor

Wednesday, February 12, 2014

Japanese scientists have added to the understanding of how to improve cell reprogramming, through the identification of two proteins that are active in egg cells to promote a totipotent state. When the proteins, TH2A/TH2B, were added to Yamanaka reprogramming factors, they synergized with those factors, making the generation of induced pluripotent stem (iPS) cells both faster and more efficient.

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