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For Better or for Worse

Endothelial Cells Play Role in Liver Scarring

By Anette Breindl
Science Editor

Monday, November 25, 2013
Endothelial cells, which line the blood vessels, have been increasingly recognized as playing important roles in the health and regeneration of the organs their blood vessels supply. A 2010 study showed they were critical for liver regeneration after injury. (See BioWorld Today, Nov 11, 2010.) Now, the same team has shown that endothelial cells also can contribute to the scarring that results from chronic liver injuries. >“Endothelial cells are not just the good guys,” senior author Shahin Rafii told BioWorld Today. “Sometimes, if they are aberrantly activated, they produce bad growth factors.”

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