Published Oct. 21 (EPO); Oct. 15 (WO)
A+ Science Invest WO 98/44785, 44786, & 44787
CNS hypoxia transgenics
Goteborg, Sweden
Transgenics animals lacking functional intermediate filament genes; for studying hypoxic edema in the nervous system.
A+ Science Invest WO 98/45464 & 45465
Complement transgenics
Goteborg, Sweden
Transgenic animals having modifications in complement genes; for studying complement activation.
Akzo Nobel EPO 872 486
Coccidiosis vaccines
Arnhem, Netherlands
Eimeria proteins isolated from a detergent hydrophilic phase; for use in preparing coccidiosis vaccines.
Amylin Pharma WO 98/45313
Obesity therapeutics
San Diego
Uncoupling protein expressed in skeletal muscle and brown adipose tissue, encoding gene; for obesity therapeutics.
Angeletti Molec. Biol. Res. Inst. WO 98/45462
Adeno-associated virus vectors
Pomezia, Italy
Adeno-associated virus vectors having inserted transgenes; for gene therapy.
Banyu Pharma WO 98/45431
Cancer metastasis gene
Tokyo
Isolation of a cancer metastasis-associated gene using differential display methods; for diagnostics/therapeutics.
Bayer EPO 872 487
Factor VIII
Pittsburgh
Preparation of recombinant Factor VIII in a protein-free, completely defined cell culture medium
Beth Israel Deaconess Med. Ctr. WO 98/45438
Uncoupling protein
Boston
Uncoupling protein, fragments, encoding gene sequences, modulators; for therapeutics.
Bio Merieux WO 98/45449
RNA quantification
Marcy l'Etoile, France
Mutated RNA polymerase that transcribes from an RNA matrix; for quantification of RNA.
Boehringer Mannheim WO 98/45428
Fanconi anemia gene
Mannheim, Germany
Pathophysiologically-relevant Fanconi anemia-associated gene, encoded protein, antibodies; for diagnostics/therapeutics.
California, Univ. of WO 98/45414
Infectious retroviral particles
La Jolla, Calif.
Infectious retroviral particles lacking the env protein that are produced from non-infectious particles.
California, Univ. of WO 98/45423
Transcription factor modulators
Oakland, Calif.
Tethering a transcriptional coactivator to a DNA binding protein and a transcription factor; for modulator screens.
California, Univ. of WO 98/45444
Chimeric immunogens
La Jolla, Calif.
Chimeric proteins acting as immunogens; encoding gene sequences; for inducing immune response.
Chang, L.-J. WO 98/44788
HIV vaccine animal model
Gainesville, Fla.
Humanized animal model systems; for studying the effects of HIV vaccines.
Chernajovsky, Y., et al. WO 98/45430
Soluble complement receptor 1
London
Soluble complement receptor 1, encoding gene sequences; for inhibiting B and T cell immune responses.
Daiichi Pharma WO 98/45463
Gene transfection facilitator
Tokyo
Substituted quaternary ammonium salt; for aiding in the transfection of genes.
Diagnocure WO 98/45420
Prostate-specific antigens
Ste-Foy, Que.
Prostate-specific antigens, encoding gene sequences, antibodies; for diagnostics and therapeutics.
Eiken EPO 872 558
Amyloid A antibodies
Tokyo
Monoclonal antibodies to human serum amyloid A protein; for immunoassays.
French Atomic Energy Comm. WO 98/45454
Prolyl-peptidase activity
Paris
Modified recombinant cyclophilin with prolyl-peptidase activity, production methods.
Genentech WO 98/45427
IGF agonists
S. San Francisco
Insulin-like growth factor (IGF) agonists that interact with IGF but do not bind its receptor; for increasing serum IGF.
Genetics Inst. WO 98/45435, 45436, & 45437
Secreted ESTs
Cambridge, Mass.
Secreted expressed sequence tags (ESTs) that are isolated from a variety of human tissue sources.
Geron WO 98/45450
Telomerase purification
Menlo Park, Calif.
Affinity purification of human telomerase using charged matrix materials.
Glasgow, Univ. of WO 98/45421
Hepatitis B diagnosis
Glasgow, U.K.
Hepatitis B mutated genes, encoded proteins; for detection and diagnosis.
Hoffmann-La Roche EPO 872 561
Gonorrhea diagnosis
Basel, Switzerland
Oligos to the cytosine DNA methyltransferase gene of Neisseria gonorrhoeae; for PCR-based diagnostics.
Human Gene Therapy Res. Inst. WO 98/45443
Radioisotope concentration
Des Moines, Iowa
Genetic engineering methods designed to concentrate radioisotopes in cells; for radiation therapy.
Human Genome Sciences WO 98/45712
20 secreted proteins
Rockville, Md.
20 human secreted proteins, encoding gene sequences, antibodies, production methods; for therapeutics.
Immune Response WO 98/44945
Non-infectious HIV
Carlsbad, Calif.
Non-infectious, protease-defective HIV particles, fragments, encoding DNA; for diagnostics and therapeutics.
Incyte Pharma WO 98/45416
Thioredoxin-like protein
Palo Alto, Calif.
Thioredoxin-like protein, encoding gene sequences, antibodies, modulators; for therapeutics.
Incyte Pharma WO 98/45439
Tumor-associated membrane protein
Palo Alto, Calif.
Human tumor-associated membrane protein, encoding gene sequences, antibodies, antagonists; for therapeutics,
Incyte Pharma WO 98/45440
Fatty acid binding protein
Palo Alto, Calif.
Human fatty acid binding protein, encoding gene sequences, antibodies, antagonists; for therapeutics.
Incyte Pharma WO 98/45441
GTP binding protein
Palo Alto, Calif.
Human GTP binding protein, encoding gene sequences, antibodies, antagonists; for therapeutics.
INSERM (Natl. Inst. Hlth. Med. Res.) WO 98/45422
Diabetes transgenics
Paris
Transgenics having deleted insulin genes; for assessing diabetes therapeutics.
Laval Univ. WO 98/45419
Therapeutics from semen
Quebec City
Transgenic animals having genes expressed in their genital tracts; for producing recombinant proteins in semen.
Leadd EPO 872 552
Apoptosis-inducing protein
Leiden, Netherlands
Apoptosis-inducing proteins from chicken anemia virus, encoding gene sequences; for treating tumor cells.
Lilly EPO 872 485 & WO 98/45426
Fungal IPC synthase genes
Indianapolis
Fungal IPC synthase genes, vectors, transformed cells; for identifying inhibitors.
Merck WO 98/44939
Cytochrome P450 3A4 antibodies
Rahway, N.J.
Antibodies against peptide fragments of cytochrome P450 3A4; for inhibiting biological activity.
Michigan St. Univ. WO 98/45417
Hyperthermostable alpha-amylase
Lansing, Mich.
Hyperthermostable extracellular alpha-amylase isolated from Pyrococcus furiosis, encoding gene sequences.
Millennium Biotherapeutics WO 98/45434
Delta3 proteins
Cambridge, Mass.
Human delta3 proteins, encoding gene sequences, antibodies; for modulating cell growth and differentiation.
Millennium Pharma WO 98/45467
TGF-signalling pathway genes
Cambridge, Mass.
Genes involved in the TGF-beta signalling pathway, encoded proteins, antibodies, antisense, transgenics.
Mindset WO 98/44955
Alzheimer's therapeutic antibodies
Old Katamon, Israel
Recombinant antibody against beta-amyloid peptide, encoding gene sequences; for Alzheimer's therapeutics.
NASA (Natl. Aeron. Space Admin.) WO 98/45468
Shear stress genes
Washington
Cell types co-cultured in a three-dimensional bioreactor; for expressing shear stress-induced genes.
NIH (Natl. Inst. Hlth.) EPO 872 553
Encephalitis vaccines
Bethesda, Md.
Chimeric flavivirus having virulence-reducing mutations; for dengue and encephalitis vaccines.
Novartis WO 98/45429
Staurosporine-induced apoptosis
Vienna, Austria
Polypeptides involved in the staurosporine-induced apoptotic pathway, production methods; for diagnostics/therapeutics.
Osiris Therapeutics WO 98/45326
Hematopoiesis transcription factors
Baltimore
Zinc finger transcription factors involved in hematopoiesis, encoding gene sequences; for therapeutics.
Pittsburgh, Univ. of WO 98/45432
Renal nuclear matrix proteins
Pittsburgh
Renal nuclear matrix proteins, encoding gene sequences; for monitoring renal cancer.
Rockefeller Univ. WO 98/45452
Chromosomal replicase
New York
DNA polymerase isolated from Thermus thermophilus that functions as a chromosomal replicase, encoding genes.
Shionogi EPO 872 559
Multiple gene detection
Osaka, Japan
Simultaneous detection of multiple genes by making cDNAs and separating them on two-dimensional electrophoresis.
SmithKline Beecham EPO 872 550
Human 7-transmembrane receptor
Philadelphia
Human 7-transmembrane receptor HACCH94, encoding gene sequences, production methods; for therapeutics.
Southern California, Univ. of WO 98/44938
ECM-targeting virions
Los Angeles
Virions having extracellular matrix (ECM)-binding proteins expressed on their surfaces; for targeting therapeutics.
SRL EPO 872 560
Frameshift mutation detection
Tokyo
Insertion of genes into vectors having reporter genes downstream; for detecting frameshift mutations.
Sumitomo Electric EPO 872 488
Fas ligand antibodies
Osaka, Japan
Monoclonal antibodies against Fas ligand, hybridomas; for detection in biological samples.
Sumitomo Electric EPO 872 555
Bacterial protein display library
Osaka, Japan
Recombinant fusion proteins expressed on bacterial surfaces; for constructing protein display libraries.
Texas, Univ. of WO 98/45433
Mitosis modulator
Austin, Texas
Human gene encoding a protein that is critical for mitosis and has leucine heptad repeats; for modulating mitosis.
Unilever WO 98/45455
Proteins from fungi
Rotterdam, Netherlands
Agrobacterium-mediated transformation of fungi; for expressing and producing recombinant proteins.
Zymogenetics WO 98/45442
Secreted F-spondin homologs
Seattle
Secreted F-spondin homologs expressed in prostate tissue, encoding gene sequences, antibodies; for diagnosis.