Published March 3 (EPO); Feb. 25 (WO)
Abbott Labs WO 99/09179
HIV-1 env antigens
Abbott Park, Ill.
HIV-1 Group O env antigens, fusion, variants, encoding gene sequences; for diagnostics and therapeutics.
Adv. Res. & Technol. Inst. WO 99/09178
C-C chemokine-like proteins
Bloomington, Ind.
Mollusc virus C-C chemokine-like proteins, encoding gene sequences; for affecting human hematopoietic cells.
Alabama, Univ. of WO 99/08713
Topical gene therapy
Birmingham, Ala.
Topical administration of gene therapy vectors using devices; for cancer therapy.
Arkansas, Univ. of WO 99/09138
Extracellular serine protease
Little Rock, Ark.
Extracellular serine protease, variants, encoding gene sequences; for diagnostics and therapeutics.
Bayer WO 99/09150
Gene targeting vector
Pittsburgh
Gene targeting vector that introduces modifications into genes via homologous recombination.
Biotransplant WO 99/09163
Stem cell factor variants
Charlestown, Mass.
Pig stem cell factor variants; for culturing cells and tissues for organ transplant.
California, Univ. of WO 99/09140
Capsaicin receptor
Oakland, Calif.
Capsaicin receptor, related polypeptides, encoding gene sequences; for therapeutics and screening modulators.
California, Univ. of WO 99/09145
Staphylococcus antibacterials
Oakland, Calif.
Staphylococcus aureus sortase-transamidase, encoding gene sequences; for screening antibiotics.
Catholic Univ. WO 99/09054
Peroxisome-associated peptide
Louvain, Belgium
Peroxisome-associated polypeptide, encoding gene sequences; for diagnosis and treatment of lung disease.
Chugai WO 99/09158
Zinc finger domain protein
Ibaraki, Japan
TNF receptor-associated protein having a zinc finger-like motif expressed in the brain, encoding gene sequences.
Chugai WO 99/09160
Cell cycle-regulating proteins
Tokyo
Cell cycle-regulating proteins, encoding gene sequences, vectors, probes; for screening inhibitors.
Cornell Univ. WO 99/09144
Glucose acylation
Ithaca, N.Y.
UDP-glucosamine:fatty acid glucosyltransferases having chain length specificity; for preparing acylated glucose.
Curagen WO 99/08510
Mutant ANP
New Haven, Conn.
Mutant atrial natriuretic factor (ANP), derivatives, analogs, encoding gene sequences; for ischemic stroke.
Dendreon WO 99/09166
Prostate tumor antigens
Mountain View, Calif.
Prostate tumor antigens, encoding gene sequences; for diagnostics and therapeutics.
Deppert, W.W. WO 99/08712
Influencing p53 linkage
Hamburg, Germany
Method for influencing the p53 linkage in target genes by coordination using conformation modulators.
Diacrin WO 99/09167
Xenotransplant tolerance
Charlestown, Mass.
Pig MHC Class I genes, encoded polypeptides; for inducing graft-specific immunological tolerance in xenotransplants.
DNAVec Res. WO 99/09191
Cancer gene therapy
Ibaraki, Japan
Recombinase-mediated gene targeting using the expression of specific transcription factors; for treating cancer.
Fox Chase Cancer Ctr. WO 99/09215
Prostate cancer diagnosis
Philadelphia
Protein that is a late stage-specific marker for prostate cancer, encoding gene sequences, antibodies; for diagnosis.
Fred Hutchinson Cancer Res. Ctr. WO 99/09153
Disabled protein homolog
Seattle
Mammalian homolog of Drosophila Disabled protein, encoding gene sequences, antibodies; for identifying modulators.
Genencor Intl. WO 99/09183
Mutated Bacillus a-amylases
Rochester, N.Y.
Mutated Bacillus licheniformis a-amylase enzymes; for altered or improved stability or activity profiles.
Genethon WO 99/09059
Familial Mediterranean Fever gene
Evry, France
Familial Mediterranean Fever gene, encoded protein, primers, probes; for diagnostics and therapeutics.
Genetics Inst. WO 99/09061
Secreted protein genes
Cambridge, Mass.
Genes encoding secreted proteins, encoded proteins, vectors; for identifying secreted protein genes.
Gustave-Roussy Inst. WO 99/09172
Insulin-like gene products
Villejuif, France
Identification and localization of polypeptides expressed by the insulin-like 4 gene; for therapeutics.
Hellman, J., et al. WO 99/09058
Osteocalcin fragments
Turku, Finland
Osteocalcin fragments isolated from urine, antibodies; for measuring bone turnover rate.
Hepavec WO 99/09193
Baculovirus gene therapy
Berlin
Baculovirus vectors with modified coats that are stable in blood; for gene therapy.
Human Genome Sciences WO 99/09152
Frizzled-like protein
Rockville, Md.
Human frizzled-like protein, encoding gene sequences; for diagnostics, therapeutics, and identifying modulators.
Human Genome Sciences WO 99/09155
70 secreted proteins
Rockville, Md.
70 human secreted proteins, encoding gene sequences, antibodies; for diagnostics and therapeutics.
Human Genome Sciences WO 99/09161
Plasminogen activator inhibitor
Rockville, Md.
Pancreas-derived plasminogen activator inhibitor, encoding gene sequences; for diagnostics and therapeutics.
Human Genome Sciences WO 99/09198
Nodal/lefty homologs
Rockville, Md.
Human nodal and lefty homologs of the TGF-_ family, encoding gene sequences; for growth-related disorders.
Hybridon WO 99/09154
HIV-specific oligos
Milford, Mass.
HIV-specific oligonucleotides complementary to the conserved gag region of the HIV-1 genome; for antisense therapeutics.
Icos WO 99/09147
PAF acetylhydrolase
Bothell, Wash.
Truncated platelet-activating factor (PAF) acetylhydrolase, encoding gene sequences; for treating inflammation.
Idun Pharma WO 99/09165
TRAIL receptors
La Jolla, Calif.
TNF-receptor associated ligand (TRAIL) receptors, encoding gene sequences; for diagnostics and therapeutics.
Incyte Pharma WO 99/09170
IgE receptor-like protein
Palo Alto, Calif.
High affinity immunoglobulin (Ig)-E receptor-like protein, encoding gene sequences, antibodies, modulators.
Incyte Pharma WO 99/09171
Ubiquitin-conjugating enzyme
Palo Alto, Calif.
Human ubiquitin-conjugating enzyme, encoding gene sequences, antibodies, modulators; for therapeutics.
Incyte Pharma WO 99/09182
Human Rab proteins
Palo Alto, Calif.
Human Rab proteins, encoding gene sequences, antibodies, modulators; for therapeutics.
Inex Pharma WO 99/09192
Non-endothelial transfection
Burnaby, British Columbia
Semliki forest virus vectors; for gene transfer into non-endothelial cardiovascular cells.
Isis Pharma WO 99/09214
Cell growth antisense
Carlsbad, Calif.
Antisense oligos to Jun N-terminal kinase; for modulating diseases involving aberrant cell growth.
Japan Tobacco WO 99/09159
Scavenger receptor-like proteins
Tokyo
Scavenger receptor-like proteins, encoding gene sequences; for inhibiting stress-induced apoptosis.
Krebs Res. Inst. WO 99/09156
Keritinization protein
Heidelberg, Germany
Protease-related protein involved in hair keritinization, encoding gene sequences, antibodies, modulators.
Krebs Res. Inst. WO 99/09177
Papillomavirus capsid protein
Heidelberg, Germany
Gene for papillomavirus main capsid protein, encoded protein, antibodies; for diagnostics and therapeutics.
Lampert, F., et al. WO 99/09157
GTPase regulator protein
Biebertal, Germany
Polypeptide with GTPase regulator activity, encoding gene sequences; for diagnostics and therapeutics.
Life Technologies WO 99/09197
DNA polymerase inhibitors
Rockville, Md.
DNA polymerase inhibitors that inactivate residual activity after amplification; for cloning genes.
McGill Univ. WO 99/09187
Plant bioreactors
Montreal
Large-scale production of recombinant human and animal proteins using plant bioreactors.
MRC (Med. Res. Counc.) WO 99/09181
Stress-activated protein kinase
London
Human stress-activated protein kinase, variants, fragments, fusions, encoding gene sequences; for drug screens.
Neose Technologies WO 99/08511
Sialyllactose in milk
Horsham, Pa.
Transgenic mammals having inserted a(2-3) trans-sialodase genes; for producing a(2-3) sialyllactose in milk.
NIH (Natl. Inst. Hlth.) WO 99/09162
CCR2 missense allele
Bethesda, Md.
Missense allele of the CCR2 gene associated with reduced risk of HIV infection; for diagnosis and therapy.
NIH (Natl. Inst. Hlth.) WO 99/09169
Pyrin gene
Bethesda, Md.
Pyrin gene, mutations, variants, encoded proteins; for diagnosing Familial Mediterranean Fever.
New Jersey, Univ. Med. & Dent. WO 99/09199
Elongation factor kinase
Newark, N.J.
Elongation factor kinase; for high throughput assays for inhibitors to control tumor growth.
Oncormed WO 99/09164
Breast cancer markers
Gaithersburg, Md.
Polymorphic haplotypes of the BRCA2 gene; for breast cancer diagnosis and therapy.
Pasteur Inst. WO 99/09186
Tuberculosis vaccines
Paris
Immunogenic exported mycobacterial proteins, encoding gene sequences; for tuberculosis vaccines.
Pasteur Inst. WO 99/09210
Deafness gene mutation
Paris
Connexin 26 gene mutation; for detection and diagnosis of prelingual non-syndromic deafness.
Quark Biotech WO 99/09046 & 09049
Hypoxia-regulated genes
Pleasanton, Calif.
Hypoxia-regulated genes, encoded proteins; for diagnosing and treating hypoxia.
Queen Mary & Westfield Coll. WO 99/09212
Telomerase detection
London
Telomerase detection assay using substrate primers and oligos that form fluorescent extension products.
Roche Diagnostics WO 99/09180
Oligosaccharide production
Mannheim, Germany
Enzymatic methods of making GDP-6-desoxyhexoses; for producing oligosaccharides.
Roche Diagnostics WO 99/09184 & 09185
Plasminogen activator variant
Mannheim, Germany
Plasminogen activator with enhanced zymogenic power and reduced fibrin linking activity; for thrombosis.
Rochester, Univ. of WO 99/08812
Chimeric P450
Rochester, N.Y.
Chimeric gene encoding bacterial and mammalian P450; for use in bioremediation.
Rochester, Univ. of WO 99/09216
Multimeric probes
Rochester, N.Y.
Labelled RNA and DNA multimeric probes; for increased sensitivity of detection.
Rubicon Labs WO 99/09139
Episomal replication
Baltimore
Episomally replicating recombinant viral vectors; for diagnostics and therapeutics.
SmithKline Beecham EPO 899 328
Human p101/P13 kinase
Brentford, U.K.
Human p101/P13 kinase subunit polypeptides, encoding gene sequences; for diagnostics and therapeutics.
SmithKline Beecham EPO 899 329
Streptococcus dextranase B
Philadelphia
Streptococcus pneumoniae dextranase B polypeptides, encoding gene sequences; for antibacterial screens.
SmithKline Beecham EPO 899 332
G-protein coupled receptor
Philadelphia
G-protein coupled receptor polypeptides, encoding gene sequences; for infection therapeutics.
SmithKline Beecham EPO 899 333
Staphylococcus ribonucleotide reductase
Philadelphia
Staphylococcus aureus ribonucleotide reductase polypeptides, encoding gene sequences; for antibacterial screens.
SmithKline Beecham EPO 899 334
Streptococcus FtsZ peptides
Philadelphia
Streptococcus pneumoniae FtsZ polypeptides, encoding gene sequences, production methods; for antibacterial screens.
SmithKline Beecham EPO 899 335
Staphylococcus murB gene
Philadelphia
Staphylococcus aureus murB polypeptide, encoding gene sequences, production methods; for antibacterial screens.
SmithKline Beecham EPO 899 336
Streptococcus spoIIIE gene
Philadelphia
Streptococcus pneumonia spoIIIE polypeptides, encoding gene sequences, production methods; for antibacterial screens.
SmithKline Beecham EPO 899 337
Staphylococcus FtsY peptides
Philadelphia
Staphylococcus aureus FtsY polypeptides, encoding gene sequences, production methods; for antibacterial screens.
SmithKline Beecham EPO 899 338
Streptococcus seryl tRNA synthetase
Philadelphia
Streptococcus pneumoniae seryl tRNA synthetase polypeptides, encoding gene sequences; for antibacterial screens.
SmithKline Beecham EPO 899 339
Chlamydia glutamyl tRNA amidotransferase
Philadelphia
Chlamydia trachomatis glutamyl tRNA amidotransferase subunit ratB, encoding gene sequences; for antibacterial screens.
SmithKline Beecham WO 99/09146
Serum inducible kinase
Philadelphia
Human serum inducible kinase polypeptides, encoding gene sequences; for diagnostics and therapeutics.
Sumitomo Electric WO 99/09060
d-l(3)mbt gene homolog
Osaka, Japan
Gene homologous to the d-l(3)mbt gene, encoded protein, antibodies.
Takara Shuzo WO 99/09213
DNA amplification
Kyoto, Japan
DNA amplification with nucleoside analogs that lower melting temperatures; for amplification without RNA purification.
Tepnel Medical WO 99/09211
DNA amplification methods
Altrincham, U.K.
Use of strand displacing DNA polymerases to regenerate restriction endonuclease sites; for amplification.
Utrecht Univ. WO 99/09176
Neisseria therapeutics
Utrecht, Netherlands
Neisseria lactoferrin binding protein, encoding gene sequences; for diagnostics and therapeutics.
Yeda Res. & Develop. WO 99/09063
IL-18 binding proteins
Rehovot, Israel
Interleukin (IL)-18 binding proteins, encoding genes, antibodies; for modulating IL-18 activity.
Zymogenetics WO 99/09168
Male contraceptives
Seattle
- Compiled by Chester A. Bisbee