Published September 15 (EPO); September 9 (WO)
Abbott Labs WO 99/45105
Highly crystalline urokinase
Abbott Park, Ill.
Biologically active urokinase, high resolution crystalline forms, encoding gene sequences.
Abbott Labs WO 99/45123
Staphylococcus detection
Abbott Park, Ill.
Recombinant staphylococcal thioredoxin reductase, encoding gene sequences; for detecting Staphylococcus.
Affymetrix WO 99/45021
Cell cycle regulated genes
Santa Clara, Calif.
Cell cycle regulated genes identified by characterizing budding yeast mRNA levels during the cell cycle.
Alabama, Univ. of WO 99/44423
Adenoviral vector replication
Birmingham, Ala.
Transcomplementation for obtaining replication of recombinant adenoviral vectors in ovarian cells.
Bio-Technology General WO 99/45020
Targeting endothelial cells
Iselin, N.J.
Tissue-specific peptide ligands that bind to endothelial cells and various tumor cells; for targeting.
Biotech. & Biol. Sci. Res. Counc. WO 99/45120
Bacterial vaccines
Swindon, U.K.
Attenuated bacterial strain having deleted genes; for vaccination against enteric bacteria.
CDC (Ctr. Disease Control) WO 99/45121
Pneumococcal vaccines
Atlanta, Ga.
Pneumococcal surface adhesion A protein, epitope fragments, encoding gene sequences, antibodies, vaccines.
CNRS (Natl. Ctr. Sci. Res.) WO 99/45108
Potassium channel family
Paris
Mechanically sensitive potassium channel family proteins activated by polyunsaturated fatty acids; for screens.
Diatech WO 99/45110
V-like domain binding molecules
Brisbane, Australia
Binding moieties having a monomeric V-like domain derived from a non-antibody ligand and having a CDR loop.
Diversa WO 99/45154
Normalized DNA libraries
San Diego
Production of normalized genomic DNA libraries; for gene quantitation.
Gustave Roussy Inst. WO 99/45102
Activating NK cells
Villejuif, France
Methods and materials for activating the cytolytic activity of natural killer (NK) cells.
Hyseq WO 99/45117
Interferon
Sunnyvale, Calif.
Interferon gene isolated from a fetal liver-spleen cDNA library, encoded protein.
Icagen WO 99/45358
Potassium channels
Durham, N.C.
Inward rectifier potassium channels, encoding gene sequences, antibodies; for screening modulators.
Icos WO 99/45111
Lectin-binding domains
Bothell, Wash.
Seven transmembrane receptor polypeptides with extracellular lectin-binding, olfactomedin- and mucin-like domains.
Imclone Systems WO 99/45018
Angiogenesis-associated antigen vaccine
New York
Modified angiogenic self antigens and antibodies that mimic antigenic determinants of angiogenic receptors.
Incyte Pharma WO 99/45115
Synapse-related glycoproteins
Palo Alto, Calif.
Human synapse-related glycoproteins, encoding gene sequences, antibodies, modulators; for therapeutics.
Iowa, Univ. of WO 99/45153
DNA sequencing method
Iowa City, Iowa
Iterative and regenerative DNA sequencing methods that do not use gel resolution.
Johns Hopkins Univ. WO 99/44625
Smallpox complement enzyme inhibitor
Baltimore, Md.
Complement enzyme inhibitor derived from smallpox; for treating transplant rejection.
Kyowa EPO 942 066
Blood-brain barrier cells
Tokyo
Brain capillary endothelial and astrocyte cell lines; for co-culture to increase glucose transport protein expression.
Ludwig Inst. Cancer Res. WO 99/45019
Tumor rejection antigen precursors
New York
Tumor rejection antigen precursors, encoding gene sequences; for diagnostics and therapeutics.
Ludwig Inst. Cancer Res. WO 99/45113
Smad binding elements
New York
Smad binding nucleic acid elements, Smad proteins and fragments binding these elements; for TGF_ signalling.
Massachusetts, Univ. of WO 99/45100
Cross-species nuclear transplantation
Amherst, Mass.
Cross-species nuclear transplantation; for producing embryonic stem cells and transgenics.
Mass. Inst. Technol. WO 99/45132
Chimeric zinc finger proteins
Cambridge, Mass.
Chimeric zinc finger proteins with improved linkers; for enhanced affinity and specificity.
Mattson, T.L. WO 99/45151
DNA degrading agents
Germantown, Md.
Using extra-chromosomal replicons for screening for agents that degrade or promote degradation of DNA.
Merial WO 99/44633
Live vaccines and adjuvants
Lyon, France
Recombinant live vaccines encoding therapeutics and an adjuvant made with acrylic polymers.
Millennium Pharma WO 99/45135
FDRG proteins
Cambridge, Mass.
FDRG proteins, encoding gene sequences, fusion proteins, antigenic peptides, antibodies; for therapeutics.
Myriad Genetics WO 99/45112
Heart disease gene
Salt Lake City
Chromosome 11-linked coronary heart disease susceptibility gene; for diagnostics and drug screening.
Onyx Pharma WO 99/45130
Baculovirus production system
Richmond, Calif.
Baculovirus production system; for automated, high-throughput expression of foreign genes.
Oxford Biomedica WO 99/45126 & 45127
Prodrug activation
Oxford, U.K.
Prodrug activating agent having localization and activation domains; for enhanced prodrug activation.
Pasteur Inst. WO 99/45028
Therapeutic inflammation antibodies
Lille, France
Monoclonal antibodies to ESM-1 protein; for treating inflammatory disease.
Penn State Univ. WO 99/45116
Treating cell growth
University Park, Penn.
Human homolog of a fungal nuclear migration gene; for the diagnosis and treatment of uncontrolled cell growth.
Senju Pharma WO 99/45107
Retinal calpain
Osaka, Japan
Calpain from eye retinal tissue, encoding gene sequences, vectors; for developing therapeutics.
Signal Pharma WO 99/45103
Generating neurons
San Diego, Calif.
Conditionally-immortalized human spinal chord cell lines; for generating neurons.
SmithKline Beecham WO 99/45030
Human G-protein coupled receptor
Philadelphia
Human G-protein coupled receptor, encoding gene sequences; for diagnostics and therapeutics.
Southern California, Univ. of WO 99/44487
Grafts making thrombolytics
Los Angeles
Genetic engineering of prosthetic bypass grafts having cells that overproduce thrombolytic enzymes.
Statens Serum Inst. WO 99/45119
Tuberculosis diagnostics
Copenhagen
Production of mycobacterial proteins in lactic acid bacteria; for diagnostics and vaccines.
Tularik WO 99/44626
Death domain suppressor proteins
S. San Francisco
Suppressor of Death Domain proteins, encoding genes, antibodies; for diagnostics and therapeutics.
Van der Bruggen, P.B., et al. WO 99/45098
Bacterial protein delivery
Corroy-Le-Grand, Belgium
Recombinant plague bacteria used to deliver proteins into eukaryotic cells.
Vanderbilt Univ. WO 99/44644
Prolonging recombinant expression
Nashville
Eukaryotic vectors designed for delaying and prolonging gene expression time that utilize a CpG methylase.
Washington Univ. WO 99/45109
Cardiac disease transgenics
St. Louis
Transgenic mice with disrupted fibroblast growth factor-9 gene; for studying cardiac pathology.
Yissum Res. Develop. WO 99/45128
Apoptosis-inducing proteins
Jerusalem, Israel
Chimeric proteins having cell-targeting specificity and apoptosis-inducing activities.
Zymogenetics WO 99/45114
Human semaphorin
Seattle