Published April 5 (EPO); March 30 (WO); April 5 (GB)
Albert Einstein Coll. Med. WO 00/17338
Hepatitis-infected mice
Bronx, N.Y.
Repopulating degenerated livers in immunocompromised mice; for studying hepatitis infection and associated cancers.
Ambion WO 00/17320
Ribonuclease inactivation
Austin, Texas
Inactivation of ribonucleases using reducing agents and heat; for preventing RNA degradation.
Bavarian Nordic Res. Ctr. WO 00/17374
Preventing retroviral destruction
Copenhagen, Denmark
Retroviral particles with encoded complement inhibitors; for preventing complement-mediated destruction.
Binax WO 00/16803
Streptococcus infection detection
Portland, Maine
Methods for rapid detection of Streptococcus pneumoniae in body fluid samples using antigen-specific antibodies.
Biosite Diagnostics WO 00/17645
Giardia infection diagnostics
San Diego
Recombinant polyclonal antibodies that bind a-1-giardin of Giardia lambria; for Giardia infection diagnostics.
Biosite Diagnostics WO 00/17646
Amoeba infection diagnostics
San Diego
Recombinant polyclonal antibodies that bind the 29 kDa antigen of Entamoeba histolytica; for amoeba infection.
Biosite Diagnostics WO 00/17647
Cryptosporidium infection diagnostics
San Diego
Cryptosporidium parvum protein disulfide isomerase, encoding gene, recombinant polyclonal antibodies; for diagnostics.
Biotraces WO 00/17397
Mass spectroscopic sequencing
Herndon, Va.
Sequencing duplex DNA by mass spectroscopy using sample preparation methods that minimize strand breakage.
Boehringer Ingelheim WO 00/17373
CELO virus-based vectors
Ingelheim, Germany
Recombinant CELO virus with a deletion allowing insertion of large pieces of foreign DNA; for gene therapy and vaccines.
Boston Univ. WO 00/17342
Intron-mediated recombination
Boston
Recombination of exons using intron-mediated techniques; for designing new protein structures.
Bristol-Myers Squibb WO 00/17337
Increased recombinant protein
Princeton, N.J.
Specific locus in Chinese hamster ovary cells that allows increased recombinant protein expression, associated vector.
Chiron EPO 990 700
Ulcer bacteria cytotoxin
Siena, Italy
Methods for fermentative growth of Helicobacter pylori; for vacuolating cytotoxin production for ulcer therapeutics.
Chugai WO 00/17395
Plasmocytomas diagnostics
Tokyo
PCR-based amplification methods for detecting plasmocytomas; for diagnosis.
Columbia Univ. WO 00/17225
Cell division inhibition
New York
Small protein that interacts with ribonucleotide reductase, for reducing cell division rates and inhibitor screens.
Du Pont WO 00/17365
Plant-produced recombinant proteins
Wilmington, Del.
Plant transgene expression systems using chromosomally-integrated components; for expression of foreign genes.
Duke Univ. WO 00/17221
Binding partner detection
Durham, N.C.
Cell-based assay for detecting binding partners using tagged heterologous proteins that localize to internal structures.
Eli Lilly WO 00/17332
Soluble trypsin variants
Indianapolis
Production of soluble recombinant trypsin and trypsinogen analogs; for subsequent enzyme activation.
Florida, Univ. of WO 00/17377
AAV vector production
Gainesville, Fla.
Large-scale production of recombinant adeno-associated viral (AAV) vectors using herpes amplicons; for gene therapy.
FMC WO 00/17333
Immobilized enzymes
Philadelphia
Enzyme immobilization in hydrocolloid polymer gel microbeads that can be hydrated; for catalyzing organic reactions.
Fox Chase Cancer Ctr. WO 00/17386
Retroviral integration inhibitors
Philadelphia
Identification of cellular enzymes that assist retroviral integration; for developing inhibitors.
Genentech WO 00/17353
Uncoupling protein homologs
S. San Francisco
Human uncoupling protein homologs, encoding gene sequences, fusions, chimeras, antibodies, production methods.
Genetic Disorders Detection Fdn. WO 00/17389
DNA mismatch analysis
Melbourne, Australia
Chemical cleavage of nucleic acid mismatches; for analyzing mutations and polymorphisms.
Genetics Inst. WO 00/16801
Hemostatic disorder therapy
Cambridge, Mass.
Treating hemostatic disorders while down-regulating immune responses to therapeutic proteins.
Genzyme WO 00/17359
Cartilage-associated genes
Framingham, Mass.
Cartilage growth and differentiation-associated genes, encoded proteins, antibodies; for therapeutics.
Georgetown Univ. WO 00/17344
Yeast response regulator
Washington
Response regulator from Candida yeast strains; for making regulatory mutants.
Haemopep Pharma WO 00/17240
Endostatin variants
Hannover, Germany
High molecular weight endostatin; for inhibiting tumor growth and capillary growth and diagnosing cancer.
Helix Res. Inst. WO 00/17335
Immobilized cDNA libraries
Chiba, Japan
cDNA libraries immobilized at their 5' end; for extension to make full-length copies.
Human Genome Sciences WO 00/17222
31 secreted proteins
Rockville, Md.
31 human secreted proteins, encoding genes, antibodies, production methods; for diagnostics and therapeutics.
Hyseq WO 00/17357
EGF-repeat domain proteins
Sunnyvale, Calif.
Epithelial growth factor (EGF)-repeat domain proteins, encoding genes; for diagnostics and therapeutics.
Hyseq WO 00/17382
Bone growth factor homologs
Sunnyvale, Calif.
Bone-derived growth factor-like proteins, encoding genes; for diagnostics and therapeutics.
I.D. Gene WO 00/17396
Skin genetic analysis
Seoul, S. Korea
Methods for obtaining DNA from epidermis using an adhesive sheet; for genetic analysis.
Incyte Genomics WO 00/17354
ISRE-binding protein
Palo Alto, Calif.
Human ISRE-binding protein, encoding gene, antibodies, modulators; for diagnostics and therapeutics.
Incyte Genomics WO 00/17355
Cytoskeletal-associated proteins
Palo Alto, Calif.
Human cytoskeletal-associated proteins, encoding genes, antibodies, modulators; for diagnostics and therapeutics.
Incyte Genomics WO 00/17358
Chaperone proteins
Palo Alto, Calif.
Human chaperone proteins, encoding genes, antibodies, modulators; for diagnostics and therapeutics.
Innogenetics WO 00/17391
Respiratory infections diagnostics
Ghent, Belgium
PCR amplification-based diagnostic techniques to identify pathogens involved in acute respiratory infections.
Inst. Phys. & Chem. Res. EPO 990 702
Full-length cDNA libraries
Wako, Japan
Methods of making full-length cDNA libraries using a 5' mRNA cap tag that can be used to isolate and purify the cDNAs.
Isis Innovation WO 00/17328
Amyloid fibrils
Oxford, UK
Amyloid fibril preparation substantially free of other proteins; for Alzheimer's research and therapy.
Isis Pharma WO 00/16809
RhoB antisense
Carlsbad, Calif.
Antisense oligos targeted to nucleic acids encoding RhoB; for disease therapeutics.
Isis Pharma WO 00/17220
FAN antisense
Carlsbad, Calif.
Antisense oligos targeted to nucleic acids encoding FAN; for disease therapeutics.
Isis Pharma WO 00/17223 & 17224
RhoA antisense
Carlsbad, Calif.
Antisense oligos targeted to nucleic acids encoding RhoA; for disease therapeutics.
Isis Pharma WO 00/17400
cREL expression modulation
Carlsbad, Calif.
Antisense modulation of cREL expression; for the treatment of diseases associated with cREL expression.
Japan Sci. & Technol. WO 00/17237
Organic anion transporter
Saitama, Japan
Cerebral organic anion transporter, encoding gene, antibodies; for diagnostics and therapeutics.
Jensen, W., et al. WO 00/17381
Distinguishing species
Wellington, Colo.
PCR amplification methods for distinguishing among species within a genus.
Kramer, M. WO 00/17232
Keratinocyte activator
Pfungstadt, Germany
Regulatory protein expressed in activated keratinocytes, encoding gene sequences, antibodies; for therapeutics.
Kyowa Hakko Kogyo EPO 990 701
Telomerase antibodies
Tokyo
Telomerase catalytic subunit monoclonal antibodies, chimeric antibodies; for cancer diagnostics and therapeutics.
Kyowa Hakko Kogyo WO 00/17339
Cell growth disease diagnostics
Tokyo
Diagnosing cell growth diseases by cytosine methylation patterns in a region affecting cytokine receptor expression.
Lee, S.J., et al. WO 00/17336
Peptide multimer production
Pusan, S. Korea
DNA cassette encoding a multimer of a biologically active peptide with attached cleavable linkers; for production.
Lek Pharma WO 00/17150
Hyperlipidemia therapeutic variants
Ljubljana, Serbia
Bacterial conversion of HMG-CoA reductase inhibitor amine salts into lactones; for treating hyperlipidemia.
London, Univ. of WO 00/16807
Dendritic polypeptides
London
Dendritic polypeptides having terminal cationic groups and a lipid anchor; for macromolecular carriers for transfection.
Maryland, Univ. of WO 00/17360
Glycoprotein hormone mutants
Baltimore, Md.
Cysteine knot glycoprotein hormone mutants having modified activities; for treating reproductive diseases.
Massachusetts, Univ. of WO 00/16802
Hepatitis B vaccines
Boston
Hepatitis B virus core antigen nucleic acid vaccines that do not contain pre-core regions.
Mass. Inst. Technol. WO 00/17321
Cells for engineered tissues
Cambridge, Mass.
Use of insulin and FGF cell culture supplements to grow cells for tissue engineering applications.
Mass. Inst. Technol. WO 00/17322
Electromagnetic cell stimulation
Cambridge, Mass.
Electromagnetic radiation stimulation of cells for triggering gene expression and enzyme release.
Mass. Inst. Technol. WO 00/17642
Biological nanocrystal applications
Cambridge, Mass.
Analyzing biological reactions using nanocrystals whose spectral emission can be tuned to a desired wavelength.
MRC (Med. Res. Counc.) GB 2 342 094
Gene product sorting
London
Iterative cycles of in vitro mutagenesis of genetic elements in microcapsules; for sorting gene product activities.
MRC (Med. Res. Counc.) WO 00/16758
Malaria therapeutics
London
Inhibitors of the Plasmodium falciparum ycf 24 gene product, assays for finding inhibitors; for malaria therapeutics.
Micromet WO 00/17390
Single cell DNA amplification
Martinsried, Germany
Amplification of the genomic DNA of single cells; for diagnostic and forensic analysis.
Millennium Pharma WO 00/17236
Apoptosis-related proteins
Cambridge, Mass.
Apoptosis-related proteins, encoding genes, antisense, antibodies, transgenics; for diagnostics and therapeutics.
Millennium Pharma WO 00/17641
Weight-modulating compounds
Cambridge, Mass.
Identification of weight-modulating compounds using a G protein-coupled receptor assay system.
Minnesota, Univ. of WO 00/17370
Complement-degrading protein
Minneapolis
Human complement C3-degrading polypeptide from Streptococcus pneumoniae; for diagnostics and therapeutics.
Mt. Sinai Hosp. WO 00/17325
Trophoblast stem cells
Toronto
Stable pluripotent trophoblast stem cell lines capable of indefinite proliferation in an undifferentiated state.
NIH (Natl. Inst. Hlth.) WO 00/17376
Replication-deficient retroviruses
Bethesda, Md.
Production of replication-deficient retroviral vectors; for gene therapy.
Nebraska, Univ. of WO 00/17399
Polymorphism detection
Lincoln, Neb.
PCR amplification-based methods for detecting polymorphisms; for genetic scanning in diagnostics and forensics.
Neuralstem Biopharma WO 00/17323
Neural progenitor cells
College Park, Md.
Cell culture methods for the efficient establishment of neural stem cells and neural progenitor cell lines.
Nexstar Pharma WO 00/17383
Factor V defect diagnostics
Boulder, Colo.
Nucleic acid ligands that bind Factor V Leiden but not wild-type Factor V in treated plasma; for diagnostics.
Nexstar Pharma WO 00/17398
Coevolving DNA sequences
Boulder, Colo.
Coevolution of DNA sequences using additional sequences that facilitate the reaction; for parallel SELEX.
Ono Pharma EPO 990 703
Stromal cell protein
Osaka, Japan
Human stromal cell polypeptide, encoding gene sequences; antibodies for therapeutics.
Otsuka Pharma WO 00/17345
Alzheimer's gene
Tokyo
Brain-specific gene useful in diagnosing and treating Alzheimer's disease, encoded protein, antibodies.
Oxford Biomedica WO 00/17371
Hypoxia response element
Oxford, UK
Hypoxia response element, repeats; for operable linkage to promoters for driving foreign gene expression.
Pharmacia & Upjohn WO 00/17369
Alzheimer's secretase
Kalamazoo, Mich.
Alzheimer's disease secretase that cleaves the _-secretase site in amyloid precursor protein, encoding gene.
Pioneer Hi-Bred WO 00/17364
Cell cycle regulation
Des Moines, Iowa
Cyclin D, encoding gene sequences, antibodies; for cell cycle regulation.
Promega WO 00/17648
Apoptosis modulating antibodies
Madison, Wis.
Antibodies to a protein cleaved by a protease during apoptosis; for modulating apoptosis.
Ribozyme Pharma WO 00/17346
Gene expression modulators
Boulder, Colo.
Hairpin hybridizer nucleic acid molecules; for modulating gene expression and identifying gene function.
Rockefeller Univ. WO 00/17356
Channel accessory molecules
New York
Ligand-gated channel receptor accessory molecules, encoding genes, antibodies, antigenic peptides; for therapeutics.
Rosetta Pharma WO 00/17402
Drug primary targets
Kirkland, Wash.
Identification of primary targets of drugs using gene expression patterns resulting from drug treatment.
Sainte Justine Hosp. WO 00/17348
Receptor peptide modulators
Montreal
G protein-coupled receptor peptide modulators produced by chemical synthesis; for treating reproductive diseases.
Sankyo EPO 990 663
Anti-Fas antibodies
Tokyo
Anti-Fas antibodies cross-reactive with human and mouse Fas; for treating abnormalities in the Fas/Fas ligand system.
Schering-Plough WO 00/17362
IL-B50
Kenilworth, N.J.
Human interleukin (IL)-B50, encoding gene sequences, antibodies; for diagnostics and therapeutics.
Schering-Plough WO 00/17363
IL-1-zeta
Kenilworth, N.J.
Interleukin (IL)-1-zeta, encoding gene sequences, fragments, antibodies; for diagnostics and therapeutics.
Shanghai Inst. Biochem WO 00/17330
Modified DNA polymerase
Shanghai, China
DNA polymerase having reduced selective discrimination against fluorescent dye-labelled dideoxynucleotides.
Shanghai Second Med. Univ. WO 00/17349
Human Hsg III gene
Shanghai, China
Human Hsg III gene, encoded protein, recombinant production techniques; for diagnostics and therapeutics.
SmithKline Beecham WO 00/16631
Antibacterial screens
Philadelphia
Bacterial murF2 polypeptides, encoding gene sequences, recombinant production methods; for antibacterial screens.
SmithKline Beecham WO 00/17644
Antibacterial screens
Philadelphia
ndp polypeptides, encoding gene sequences, recombinant production techniques; for screening antibacterials.
Solomin, L., et al. WO 00/17334
Nuclear receptor ligands
Stockholm
Transgenics for in vivo detection and analysis of ligands for nuclear receptors.
South Carolina, Med. Univ. of WO 00/17326
Derived cardiomyocytes
Charleston, S.C.
Cardiomyocytes and skeletal muscle cells derived from hematopoietic stem cells; for tissue replacement.
Taisho Pharma WO 00/17238
Cell proliferation promotion
Tokyo
Proteins with cell proliferation promotion effect, encoding gene sequences; for diagnostics and therapeutics.
Thomas Jefferson Univ. WO 00/17329
Apoptosis induction
Philadelphia
Rec2 kinase-induced phosphorylation of a serine-containing substrate; for cell cycle arrest and apoptosis.
Thrombosis Res. WO 00/17658
Heart attack prognosis
Boston
Monoclonal antibody-based methods for measuring Factor IX activation protein; for heart attack and stroke diagnosis.
Transgene WO 00/17366
Therapeutic pre-treatment
Strasbourg, France
Pharmaceutical pre-treatment for use with drugs or pro-drugs that are over- or under-metabolized.
Vlaams Biotech Inst. WO 00/17375
Hemophilia gene therapy
Zwijnaarde, Netherlands
Gene therapy system using pseudotyped retroviral vectors allowing stable therapeutic expression; for hemophilia.
Westmead Inst. Hlth. Res. WO 00/17219
Herpes virus 6 detection
Westmead, Australia
Detection oh human herpes virus 6 using PCR-based amplification techniques.
Wisconsin, Univ. of WO 00/17343
Insertional mutagenesis
Madison, Wis.
Making random insertional mutations using transposons and transposases; for genomic sequence changes.
Wood, C.B. GB 2 342 042
Cancer gene therapy
Stokepoges, UK
Cancer gene therapy using adenoviral vectors encoding wild type and deleted versions of the p53 gene.
Yu, L. WO 00/17350
Growth differentiation factor
Shanghai, China
Human growth differentiation factor, encoding gene, production techniques; for diagnostics and therapeutics.
Yu, L. WO 00/17351
Hepatoma-derived growth factor
Shanghai, China
Hepatoma-derived growth factor, encoding gene sequences, production methods; for diagnostics and therapeutics.
Zeneca WO 00/17392
VCAM-1 polymorphisms
London
Polymorphisms in the human vascular cell adhesion molecule (VCAM)-1 gene; for diagnostics and therapeutics.
Zeneca WO 00/17393
_1 integrin subunit polymorphisms
London
Polymorphisms in the human _1 integrin subunit gene; for diagnostics and therapeutics.
Zeneca WO 00/17394
a4 integrin subunit polymorphisms
London
Polymorphisms in the human a4 integrin subunit gene; for diagnostics and therapeutics.
Zymogenetics WO 00/17235
Cytokine receptor
Seattle
Cytokine receptor zalpha11, encoding chromosome 16 gene; for hematopoietic cell growth ligand screens and therapeutics.
Zymogenetics WO 00/17361
Interferon-epsilon
Seattle
Interferon-epsilon; for inducing immune responses against infectious agents.