Published April 5 (EPO); March 30 (WO); April 5 (GB)

Albert Einstein Coll. Med. WO 00/17338

Hepatitis-infected mice

Bronx, N.Y.

Repopulating degenerated livers in immunocompromised mice; for studying hepatitis infection and associated cancers.

Ambion WO 00/17320

Ribonuclease inactivation

Austin, Texas

Inactivation of ribonucleases using reducing agents and heat; for preventing RNA degradation.

Bavarian Nordic Res. Ctr. WO 00/17374

Preventing retroviral destruction

Copenhagen, Denmark

Retroviral particles with encoded complement inhibitors; for preventing complement-mediated destruction.

Binax WO 00/16803

Streptococcus infection detection

Portland, Maine

Methods for rapid detection of Streptococcus pneumoniae in body fluid samples using antigen-specific antibodies.

Biosite Diagnostics WO 00/17645

Giardia infection diagnostics

San Diego

Recombinant polyclonal antibodies that bind a-1-giardin of Giardia lambria; for Giardia infection diagnostics.

Biosite Diagnostics WO 00/17646

Amoeba infection diagnostics

San Diego

Recombinant polyclonal antibodies that bind the 29 kDa antigen of Entamoeba histolytica; for amoeba infection.

Biosite Diagnostics WO 00/17647

Cryptosporidium infection diagnostics

San Diego

Cryptosporidium parvum protein disulfide isomerase, encoding gene, recombinant polyclonal antibodies; for diagnostics.

Biotraces WO 00/17397

Mass spectroscopic sequencing

Herndon, Va.

Sequencing duplex DNA by mass spectroscopy using sample preparation methods that minimize strand breakage.

Boehringer Ingelheim WO 00/17373

CELO virus-based vectors

Ingelheim, Germany

Recombinant CELO virus with a deletion allowing insertion of large pieces of foreign DNA; for gene therapy and vaccines.

Boston Univ. WO 00/17342

Intron-mediated recombination

Boston

Recombination of exons using intron-mediated techniques; for designing new protein structures.

Bristol-Myers Squibb WO 00/17337

Increased recombinant protein

Princeton, N.J.

Specific locus in Chinese hamster ovary cells that allows increased recombinant protein expression, associated vector.

Chiron EPO 990 700

Ulcer bacteria cytotoxin

Siena, Italy

Methods for fermentative growth of Helicobacter pylori; for vacuolating cytotoxin production for ulcer therapeutics.

Chugai WO 00/17395

Plasmocytomas diagnostics

Tokyo

PCR-based amplification methods for detecting plasmocytomas; for diagnosis.

Columbia Univ. WO 00/17225

Cell division inhibition

New York

Small protein that interacts with ribonucleotide reductase, for reducing cell division rates and inhibitor screens.

Du Pont WO 00/17365

Plant-produced recombinant proteins

Wilmington, Del.

Plant transgene expression systems using chromosomally-integrated components; for expression of foreign genes.

Duke Univ. WO 00/17221

Binding partner detection

Durham, N.C.

Cell-based assay for detecting binding partners using tagged heterologous proteins that localize to internal structures.

Eli Lilly WO 00/17332

Soluble trypsin variants

Indianapolis

Production of soluble recombinant trypsin and trypsinogen analogs; for subsequent enzyme activation.

Florida, Univ. of WO 00/17377

AAV vector production

Gainesville, Fla.

Large-scale production of recombinant adeno-associated viral (AAV) vectors using herpes amplicons; for gene therapy.

FMC WO 00/17333

Immobilized enzymes

Philadelphia

Enzyme immobilization in hydrocolloid polymer gel microbeads that can be hydrated; for catalyzing organic reactions.

Fox Chase Cancer Ctr. WO 00/17386

Retroviral integration inhibitors

Philadelphia

Identification of cellular enzymes that assist retroviral integration; for developing inhibitors.

Genentech WO 00/17353

Uncoupling protein homologs

S. San Francisco

Human uncoupling protein homologs, encoding gene sequences, fusions, chimeras, antibodies, production methods.

Genetic Disorders Detection Fdn. WO 00/17389

DNA mismatch analysis

Melbourne, Australia

Chemical cleavage of nucleic acid mismatches; for analyzing mutations and polymorphisms.

Genetics Inst. WO 00/16801

Hemostatic disorder therapy

Cambridge, Mass.

Treating hemostatic disorders while down-regulating immune responses to therapeutic proteins.

Genzyme WO 00/17359

Cartilage-associated genes

Framingham, Mass.

Cartilage growth and differentiation-associated genes, encoded proteins, antibodies; for therapeutics.

Georgetown Univ. WO 00/17344

Yeast response regulator

Washington

Response regulator from Candida yeast strains; for making regulatory mutants.

Haemopep Pharma WO 00/17240

Endostatin variants

Hannover, Germany

High molecular weight endostatin; for inhibiting tumor growth and capillary growth and diagnosing cancer.

Helix Res. Inst. WO 00/17335

Immobilized cDNA libraries

Chiba, Japan

cDNA libraries immobilized at their 5' end; for extension to make full-length copies.

Human Genome Sciences WO 00/17222

31 secreted proteins

Rockville, Md.

31 human secreted proteins, encoding genes, antibodies, production methods; for diagnostics and therapeutics.

Hyseq WO 00/17357

EGF-repeat domain proteins

Sunnyvale, Calif.

Epithelial growth factor (EGF)-repeat domain proteins, encoding genes; for diagnostics and therapeutics.

Hyseq WO 00/17382

Bone growth factor homologs

Sunnyvale, Calif.

Bone-derived growth factor-like proteins, encoding genes; for diagnostics and therapeutics.

I.D. Gene WO 00/17396

Skin genetic analysis

Seoul, S. Korea

Methods for obtaining DNA from epidermis using an adhesive sheet; for genetic analysis.

Incyte Genomics WO 00/17354

ISRE-binding protein

Palo Alto, Calif.

Human ISRE-binding protein, encoding gene, antibodies, modulators; for diagnostics and therapeutics.

Incyte Genomics WO 00/17355

Cytoskeletal-associated proteins

Palo Alto, Calif.

Human cytoskeletal-associated proteins, encoding genes, antibodies, modulators; for diagnostics and therapeutics.

Incyte Genomics WO 00/17358

Chaperone proteins

Palo Alto, Calif.

Human chaperone proteins, encoding genes, antibodies, modulators; for diagnostics and therapeutics.

Innogenetics WO 00/17391

Respiratory infections diagnostics

Ghent, Belgium

PCR amplification-based diagnostic techniques to identify pathogens involved in acute respiratory infections.

Inst. Phys. & Chem. Res. EPO 990 702

Full-length cDNA libraries

Wako, Japan

Methods of making full-length cDNA libraries using a 5' mRNA cap tag that can be used to isolate and purify the cDNAs.

Isis Innovation WO 00/17328

Amyloid fibrils

Oxford, UK

Amyloid fibril preparation substantially free of other proteins; for Alzheimer's research and therapy.

Isis Pharma WO 00/16809

RhoB antisense

Carlsbad, Calif.

Antisense oligos targeted to nucleic acids encoding RhoB; for disease therapeutics.

Isis Pharma WO 00/17220

FAN antisense

Carlsbad, Calif.

Antisense oligos targeted to nucleic acids encoding FAN; for disease therapeutics.

Isis Pharma WO 00/17223 & 17224

RhoA antisense

Carlsbad, Calif.

Antisense oligos targeted to nucleic acids encoding RhoA; for disease therapeutics.

Isis Pharma WO 00/17400

cREL expression modulation

Carlsbad, Calif.

Antisense modulation of cREL expression; for the treatment of diseases associated with cREL expression.

Japan Sci. & Technol. WO 00/17237

Organic anion transporter

Saitama, Japan

Cerebral organic anion transporter, encoding gene, antibodies; for diagnostics and therapeutics.

Jensen, W., et al. WO 00/17381

Distinguishing species

Wellington, Colo.

PCR amplification methods for distinguishing among species within a genus.

Kramer, M. WO 00/17232

Keratinocyte activator

Pfungstadt, Germany

Regulatory protein expressed in activated keratinocytes, encoding gene sequences, antibodies; for therapeutics.

Kyowa Hakko Kogyo EPO 990 701

Telomerase antibodies

Tokyo

Telomerase catalytic subunit monoclonal antibodies, chimeric antibodies; for cancer diagnostics and therapeutics.

Kyowa Hakko Kogyo WO 00/17339

Cell growth disease diagnostics

Tokyo

Diagnosing cell growth diseases by cytosine methylation patterns in a region affecting cytokine receptor expression.

Lee, S.J., et al. WO 00/17336

Peptide multimer production

Pusan, S. Korea

DNA cassette encoding a multimer of a biologically active peptide with attached cleavable linkers; for production.

Lek Pharma WO 00/17150

Hyperlipidemia therapeutic variants

Ljubljana, Serbia

Bacterial conversion of HMG-CoA reductase inhibitor amine salts into lactones; for treating hyperlipidemia.

London, Univ. of WO 00/16807

Dendritic polypeptides

London

Dendritic polypeptides having terminal cationic groups and a lipid anchor; for macromolecular carriers for transfection.

Maryland, Univ. of WO 00/17360

Glycoprotein hormone mutants

Baltimore, Md.

Cysteine knot glycoprotein hormone mutants having modified activities; for treating reproductive diseases.

Massachusetts, Univ. of WO 00/16802

Hepatitis B vaccines

Boston

Hepatitis B virus core antigen nucleic acid vaccines that do not contain pre-core regions.

Mass. Inst. Technol. WO 00/17321

Cells for engineered tissues

Cambridge, Mass.

Use of insulin and FGF cell culture supplements to grow cells for tissue engineering applications.

Mass. Inst. Technol. WO 00/17322

Electromagnetic cell stimulation

Cambridge, Mass.

Electromagnetic radiation stimulation of cells for triggering gene expression and enzyme release.

Mass. Inst. Technol. WO 00/17642

Biological nanocrystal applications

Cambridge, Mass.

Analyzing biological reactions using nanocrystals whose spectral emission can be tuned to a desired wavelength.

MRC (Med. Res. Counc.) GB 2 342 094

Gene product sorting

London

Iterative cycles of in vitro mutagenesis of genetic elements in microcapsules; for sorting gene product activities.

MRC (Med. Res. Counc.) WO 00/16758

Malaria therapeutics

London

Inhibitors of the Plasmodium falciparum ycf 24 gene product, assays for finding inhibitors; for malaria therapeutics.

Micromet WO 00/17390

Single cell DNA amplification

Martinsried, Germany

Amplification of the genomic DNA of single cells; for diagnostic and forensic analysis.

Millennium Pharma WO 00/17236

Apoptosis-related proteins

Cambridge, Mass.

Apoptosis-related proteins, encoding genes, antisense, antibodies, transgenics; for diagnostics and therapeutics.

Millennium Pharma WO 00/17641

Weight-modulating compounds

Cambridge, Mass.

Identification of weight-modulating compounds using a G protein-coupled receptor assay system.

Minnesota, Univ. of WO 00/17370

Complement-degrading protein

Minneapolis

Human complement C3-degrading polypeptide from Streptococcus pneumoniae; for diagnostics and therapeutics.

Mt. Sinai Hosp. WO 00/17325

Trophoblast stem cells

Toronto

Stable pluripotent trophoblast stem cell lines capable of indefinite proliferation in an undifferentiated state.

NIH (Natl. Inst. Hlth.) WO 00/17376

Replication-deficient retroviruses

Bethesda, Md.

Production of replication-deficient retroviral vectors; for gene therapy.

Nebraska, Univ. of WO 00/17399

Polymorphism detection

Lincoln, Neb.

PCR amplification-based methods for detecting polymorphisms; for genetic scanning in diagnostics and forensics.

Neuralstem Biopharma WO 00/17323

Neural progenitor cells

College Park, Md.

Cell culture methods for the efficient establishment of neural stem cells and neural progenitor cell lines.

Nexstar Pharma WO 00/17383

Factor V defect diagnostics

Boulder, Colo.

Nucleic acid ligands that bind Factor V Leiden but not wild-type Factor V in treated plasma; for diagnostics.

Nexstar Pharma WO 00/17398

Coevolving DNA sequences

Boulder, Colo.

Coevolution of DNA sequences using additional sequences that facilitate the reaction; for parallel SELEX.

Ono Pharma EPO 990 703

Stromal cell protein

Osaka, Japan

Human stromal cell polypeptide, encoding gene sequences; antibodies for therapeutics.

Otsuka Pharma WO 00/17345

Alzheimer's gene

Tokyo

Brain-specific gene useful in diagnosing and treating Alzheimer's disease, encoded protein, antibodies.

Oxford Biomedica WO 00/17371

Hypoxia response element

Oxford, UK

Hypoxia response element, repeats; for operable linkage to promoters for driving foreign gene expression.

Pharmacia & Upjohn WO 00/17369

Alzheimer's secretase

Kalamazoo, Mich.

Alzheimer's disease secretase that cleaves the _-secretase site in amyloid precursor protein, encoding gene.

Pioneer Hi-Bred WO 00/17364

Cell cycle regulation

Des Moines, Iowa

Cyclin D, encoding gene sequences, antibodies; for cell cycle regulation.

Promega WO 00/17648

Apoptosis modulating antibodies

Madison, Wis.

Antibodies to a protein cleaved by a protease during apoptosis; for modulating apoptosis.

Ribozyme Pharma WO 00/17346

Gene expression modulators

Boulder, Colo.

Hairpin hybridizer nucleic acid molecules; for modulating gene expression and identifying gene function.

Rockefeller Univ. WO 00/17356

Channel accessory molecules

New York

Ligand-gated channel receptor accessory molecules, encoding genes, antibodies, antigenic peptides; for therapeutics.

Rosetta Pharma WO 00/17402

Drug primary targets

Kirkland, Wash.

Identification of primary targets of drugs using gene expression patterns resulting from drug treatment.

Sainte Justine Hosp. WO 00/17348

Receptor peptide modulators

Montreal

G protein-coupled receptor peptide modulators produced by chemical synthesis; for treating reproductive diseases.

Sankyo EPO 990 663

Anti-Fas antibodies

Tokyo

Anti-Fas antibodies cross-reactive with human and mouse Fas; for treating abnormalities in the Fas/Fas ligand system.

Schering-Plough WO 00/17362

IL-B50

Kenilworth, N.J.

Human interleukin (IL)-B50, encoding gene sequences, antibodies; for diagnostics and therapeutics.

Schering-Plough WO 00/17363

IL-1-zeta

Kenilworth, N.J.

Interleukin (IL)-1-zeta, encoding gene sequences, fragments, antibodies; for diagnostics and therapeutics.

Shanghai Inst. Biochem WO 00/17330

Modified DNA polymerase

Shanghai, China

DNA polymerase having reduced selective discrimination against fluorescent dye-labelled dideoxynucleotides.

Shanghai Second Med. Univ. WO 00/17349

Human Hsg III gene

Shanghai, China

Human Hsg III gene, encoded protein, recombinant production techniques; for diagnostics and therapeutics.

SmithKline Beecham WO 00/16631

Antibacterial screens

Philadelphia

Bacterial murF2 polypeptides, encoding gene sequences, recombinant production methods; for antibacterial screens.

SmithKline Beecham WO 00/17644

Antibacterial screens

Philadelphia

ndp polypeptides, encoding gene sequences, recombinant production techniques; for screening antibacterials.

Solomin, L., et al. WO 00/17334

Nuclear receptor ligands

Stockholm

Transgenics for in vivo detection and analysis of ligands for nuclear receptors.

South Carolina, Med. Univ. of WO 00/17326

Derived cardiomyocytes

Charleston, S.C.

Cardiomyocytes and skeletal muscle cells derived from hematopoietic stem cells; for tissue replacement.

Taisho Pharma WO 00/17238

Cell proliferation promotion

Tokyo

Proteins with cell proliferation promotion effect, encoding gene sequences; for diagnostics and therapeutics.

Thomas Jefferson Univ. WO 00/17329

Apoptosis induction

Philadelphia

Rec2 kinase-induced phosphorylation of a serine-containing substrate; for cell cycle arrest and apoptosis.

Thrombosis Res. WO 00/17658

Heart attack prognosis

Boston

Monoclonal antibody-based methods for measuring Factor IX activation protein; for heart attack and stroke diagnosis.

Transgene WO 00/17366

Therapeutic pre-treatment

Strasbourg, France

Pharmaceutical pre-treatment for use with drugs or pro-drugs that are over- or under-metabolized.

Vlaams Biotech Inst. WO 00/17375

Hemophilia gene therapy

Zwijnaarde, Netherlands

Gene therapy system using pseudotyped retroviral vectors allowing stable therapeutic expression; for hemophilia.

Westmead Inst. Hlth. Res. WO 00/17219

Herpes virus 6 detection

Westmead, Australia

Detection oh human herpes virus 6 using PCR-based amplification techniques.

Wisconsin, Univ. of WO 00/17343

Insertional mutagenesis

Madison, Wis.

Making random insertional mutations using transposons and transposases; for genomic sequence changes.

Wood, C.B. GB 2 342 042

Cancer gene therapy

Stokepoges, UK

Cancer gene therapy using adenoviral vectors encoding wild type and deleted versions of the p53 gene.

Yu, L. WO 00/17350

Growth differentiation factor

Shanghai, China

Human growth differentiation factor, encoding gene, production techniques; for diagnostics and therapeutics.

Yu, L. WO 00/17351

Hepatoma-derived growth factor

Shanghai, China

Hepatoma-derived growth factor, encoding gene sequences, production methods; for diagnostics and therapeutics.

Zeneca WO 00/17392

VCAM-1 polymorphisms

London

Polymorphisms in the human vascular cell adhesion molecule (VCAM)-1 gene; for diagnostics and therapeutics.

Zeneca WO 00/17393

_1 integrin subunit polymorphisms

London

Polymorphisms in the human _1 integrin subunit gene; for diagnostics and therapeutics.

Zeneca WO 00/17394

a4 integrin subunit polymorphisms

London

Polymorphisms in the human a4 integrin subunit gene; for diagnostics and therapeutics.

Zymogenetics WO 00/17235

Cytokine receptor

Seattle

Cytokine receptor zalpha11, encoding chromosome 16 gene; for hematopoietic cell growth ligand screens and therapeutics.

Zymogenetics WO 00/17361

Interferon-epsilon

Seattle

Interferon-epsilon; for inducing immune responses against infectious agents.