Published July 19 (EP); July 13 (WO)
Abbott Labs Human desaturases WO 00/40705
Abbott Park, Ill.
Human desaturases that convert saturated fatty acids into unsaturated ones; for therapeutics.
Actinova Streptococcus WO 00/40729
Cambridge, UK vaccines
Streptococcal ABC transporter protein, variants; for immune response generation and vaccines.
Adv. Res. & Technol. Antiviral screens WO 00/40759
Indianapolis
Isolated recombinant flavivirus RNA-dependent RNA polymerase; for diagnostics and antiviral screens.
Ajinomoto Transglutaminase WO 00/40706
Tokyo production
Process for producing active transglutaminase from the denatured form made in bacteria.
Alfacell Antitumor frog WO 00/40608
Bloomfield, N.J. proteins
Pancreatic ribonuclease-like proteins from Rana pipiens frog eggs that are active against tumors.
Amaxa Nuclear transgene WO 00/40742
Cologne, Germany transport
Cellular nuclear transport agent for transferring gene sequences across the nuclear membrane.
Amersham Pharmacia DNA sequencing WO 00/40750
Uppsala, Sweden
Sequencing DNA using a microfluidic device and the luciferase-luciferin reaction for detecting pyrophosphate.
Arkansas, Univ. of Proteoglycan WO 00/40253
Little Rock, Ark. biosynthesis
Glycosaminogylcans covalently linked to a proteoglycan biosynthesis moiety; for therapeutics.
Atlantic Biopharma a-fetoprotein WO 00/40693
Cambridge, Mass. production
Expression of secreted a-fetoprotein in the milk or urine of transgenic animals.
Baylor Coll. Med. Mammary tumor WO 00/40756
Houston coactivator
Coactivator overexpressed in mammary tumors, methods for identification; for endocrine tumor therapy.
Beth Israel Deaconess Calcium channel WO 00/40614 Hosp. family
Boston
Calcium channel genes, encoded proteins, fragments, variants, binding ligands; for diagnostics and therapeutics.
Biotechnol. Inst. Recombinant EP 1 020 523
Hoersholm, Denmark hexose oxidase
Recombinant hexose oxidase, encoding gene sequences; for pharmaceuticals manufacturing.
Boston Univ. Cloning methods WO 00/40715
Boston
Nucleic acid cloning in which product molecules are produced through iterative synthetic reactions that amplify DNA.
Brigham & Women's Cytokine release WO 00/40604 Hosp. modification
Boston
Modulation of cytokine release by aE_gamma-expressing cells; for modifying the Th2 cytokine response.
Bristol-Myers Squibb Hepatitis C WO 00/40707
Princeton, N.J. protease inhibitors
Modified forms of hepatitis C virus NS3 protease, fusion proteins, encoding genes; for inhibitor screens.
Bristol-Myers Squibb Identifying protease WO 00/40745
Princeton, N.J. modulators
Prokaryotic cell system for identifying protease modulators and protease cleavage sites.
California, Univ. of Enediyne antitumor WO 00/40596
Oakland, Calif. antibiotic
Streptococcus gene cluster responsible for the biosynthesis of the antitumor antibiotic enediyne; for production.
California, Univ. of HIV replication WO 00/40606
La Jolla, Calif. modulation
Modulation of HIV replication using cellular nuclear export proteins and their homologs; for therapeutics.
California, Univ. of Bleomycin WO 00/40704
Oakland, Calif. production
Streptomyces gene cluster responsible for the biosynthesis of bleomycin; for cancer chemotherapeutic production.
Calif. Inst. Technol. Polycystic kidney WO 00/40711
Pasadena, Calif. gene model
Polycystic kidney gene homologs required for male mating behavior in nematodes; for disease modeling.
CNRS (Natl. Ctr. Circularized nucleic WO 00/40735 Sci. Res.) acids
Paris
Construction of recombinant nucleic acids circularized by DNA compacting agents.
Chicago, Univ. of Herpes simplex WO 00/40734
Chicago antitumor vectors
Recombinant herpes simplex viruses having genes encoding cytokines; for treating cancer.
Chiron T-cell metastasis WO 00/40607
Emeryville, Calif. protein
Genes encoding T-cell lymphoma invasion and metastasis 2 proteins, encoded proteins, antisense, ribozymes.
Chugai Differentiated EP 1 020 517
Tokyo chondrocyte gene
Gene expressed in differentiated human chondrocytes cultured in dibutyryl cAMP.
Chugai Human antibody EP 1 020 522
Tokyo
Reshaped natural human antibody HM1.24 that has low CDR antigenicity.
Chugai Res. Inst. Organic cation EP 1 020 518 Molec. Med. transporter genes
Ibaraki, Japan
Organic cation transporter gene homologs isolated from a fetal gene library, encoded proteins.
Commonwealth Identifying electro- WO 00/40959 Biotech phoresis lanes
Richmond, Va.
Marker reagent for use in identifying individual lanes on an electrophoresis gel during DNA sequencing.
Cornell Univ. SNP identification WO 00/40755
Ithaca, N.Y.
Accelerated alignment of clones in genomic sequencing and identification of single nucleotide polymorphisms (SNPs).
CuraGen Nucleic acid WO 00/40757
New Haven, Conn. identification
Methods for identifying nucleic acids present in samples in differing amounts by partitioning the sample.
Eiken Nucleic acid EP 1 020 534
Tokyo synthesis
Isothermal process for synthesizing highly specific nucleic acids using simple reagents.
Eli Lilly Fas ligand inhibitors EP 1 020 521
Indianapolis
Fas ligand inhibitor polypeptides, encoding gene sequences, transgenics, chimerics.
Genentech IGF-1 variants WO 00/40612
S. San Francisco & 40613
Insulin-like growth factor (IGF)-1 variants that bind to IGF binding protein-1 and -2; for improved half-lives.
Genesoft Modulating gene WO 00/40605
S. San Francisco expression
Cyclic polyamides having basepair-specific interactions with double-stranded nucleic acids; for expression modulation.
Genway Biotech Monellin production WO 00/40603
N. Wales, Penn.
Production of the recombinant sweetener monellin using a methylotrophic yeast expression system.
Human Genome Chemokine _-10 WO 00/40726 Sciences muteins
Rockville, Md.
Human chemokine _-10 muteins, encoding gene sequences; for autoimmune and inflammation therapeutics.
Hyseq Enhanced gene WO 00/40758
Sunnyvale, Calif. sequencing
Methods for enhanced sequencing by hybridization using pools of probes; for gene identification.
Incyte Genomics Insulin synthesis WO 00/40722
Palo Alto, Calif. genes
Insulin synthesis genes, encoded proteins, antibodies, modulators; for treating insulin-related diseases.
Incyte Genomics Cyclic nucleotide WO 00/40733
Palo Alto, Calif. phosphodiesterases
Human cyclic nucleotide phosphodiesterases, encoding genes, antibodies, modulators; for diagnostics and therapeutics.
Introgene T cells for tumors EP 1 020 519
Leiden, Netherlands
Minor histocompatibility antigens; for inducing cytotoxic T-cell reactivity to tumors.
Introgene Preventing EP 1 020 520
Leiden, immunoresponses
Netherlands
Mutant polymorphic mononuclear lymphocyte proteins; for prevention of immunoresponses to cells.
Introgene Smooth muscle EP 1 020 529
Leiden, gene expression
Netherlands
Gene vectors having expression cassettes that cause expression in smooth muscle and endothelial cells.
Introgene Promoting WO 00/40740
Leiden, angiogenesis
Netherlands
Vectors containing genes that encode proteins capable of increasing nitric oxide production; for angiogenesis.
Isis Pharma Anti-apoptotic WO 00/40595
Carlsbad, Calif. antisense
Antisense modulation of anti-apoptotic Bcl-2-related proteins; for diagnostics and therapeutics.
Kikkoman Mutant luciferase EP 1 020 524,
Chiba, Japan WO 00/40731, & 40732
Mutant bioluminescent firefly luciferase protein having increased thermostability, production methods.
Kikkoman Mutant creatine WO 00/40708
Chiba, Japan amidohydrolase
Mutant creatine amidohydrolase having increased thermostability, production methods.
Krebs Res. Ctr. Electron microscopy WO 00/40736
Heidelberg, Germany markers
Vectors having repetitive primer elements; for use as a marker in electron microscopy.
Kyowa Hakko Kogyo Protein decompo- WO 00/40609
Tokyo sition control
Protein useful in diagnosing and treating diseases induced by modulation of protein decomposition, encoding genes.
Leeds, Univ. of Tissue repair WO 00/40719
Leeds, UK protein
Tissue repair protein, encoding gene, antibodies; for wound-healing diagnostics and therapeutics.
Lexicon Genetics Seven transmem- WO 00/40724
The Woodlands, brane receptors
Texas
Human seven transmembrane G protein-coupled receptors, encoding genes; for diagnostics and therapeutics.
Liew, C.-C. Gene transcripts WO 00/40749
Willowdale, Ont. in blood
Reverse transcriptase PCR amplification methods for identifying gene transcripts in samples from blood.
Life Technologies Nucleic acid WO 00/40697
Rockville, Md. isolation
Methods of separating nucleic acids using an integrated lysis-chromatography matrix; for rapid isolation.
Lorne Park Res. Nucleic acid WO 00/40753
Mississauga, Ont. binding proteins
Assay using fluorescent quenching of labels to detect protein binding to nucleic acids.
Massachusetts, Polyhydroalkanoate WO 00/40730 Univ. of synthesis
Amherst, Mass.
Bacillus megaterium genes for polyhydroalkanoate biosynthesis, encoded proteins; for production.
Mass. Gen. Hosp. PTH receptor WO 00/40698
Boston variant
Parathyroid hormone (PTH) receptor variant having a deleted extracellular amino-terminus ligand binding domain.
McMaster Univ. Hypersensitivity WO 00/40713
Hamilton, Ont. modulation
Modifying immune hypersensitivity reactions by interfering with IgE-antigen complex interaction with CD23 receptors.
MRC (Med. Res. Evolution by WO 00/40712 Counc.) mutagenesis
London
Microencapsulated genetic elements; for in vitro transcription and evolution by mutagenesis.
Milan Univ. GNRP mutants WO 00/40718
Milan, Italy
Guanine nucleotide releasing protein (GNRP) mutants, encoding gene; for cardiovascular disease and inflammation.
Mt. Sinai Sch. Med. Secreted protein EP 1 020 528
New York production
Methods for producing secreted proteins by linking desired genes to regulatory sequences causing secretion.
NIH (Natl. Inst. Hlth.) Lentivirus vector WO 00/40741
Bethesda, Md. system
Improving encapsidation of transgene RNA using a lentiviral retroviral packaging and transfer system; for gene therapy.
Nottingham Trent Cancer-associated WO 00/40752 Univ. genes
Nottingham, UK
Cancer-associated genes, encoded proteins; for prostate cancer diagnostics and therapeutics.
Oligos Phosphodiesterase WO 00/40714
Wilsonville, Ore. inhibitors
Therapeutic oligonucleotide primers targeted at inhibiting phosphodiesterase; for treating thrombosis and hypertension.
Rhein Biotech G-CSF activity WO 00/40727
Dusseldorf, Germany protein
Recombinant growth factor having G-CSF activity, encoding genes; for blood cell maturation.
Schering Monocyte-derived WO 00/40721
Kenilworth, N.J. proteins
Monocyte-derived proteins, encoding gene sequences, antibodies; for diagnostics and therapeutics.
Sippel, A.E., et al. Nuclear receptor WO 00/40717
Freiburg, Germany ligand binding
Methods for cellular high-throughput detection of nuclear ligand receptor interactions in the Ras pathway.
SmithKline Beecham Antibacterial screens WO 00/40594
Philadelphia
Bacterial AcpS genes, encoded proteins, recombinant production methods; for antibacterial screens.
Stichting Labs Meloidogyne WO 00/40754
Wageningen, infection
Netherlands
DNA oligonucleotide probe that is specific for Meloidogyne strains; for PCR-based detection of infection.
Sumitomo Chemical Transcription WO 00/40720
Osaka, Japan promoter assay
Cells expressing a gene encoding a ligand-responsive regulatory factor; for finding transcription promoters.
Takeda Chemical Chemotherapy WO 00/40610
Osaka, Japan protection
Production of activated MPIF-1delta23 in large amounts; for protecting bone marrow from cancer chemotherapeutics.
Takeda Chemical Appetite WO 00/40725
Osaka, Japan modulation
Methods for screening SLC-1 modulators; for appetite and smooth muscle modulation.
Vermont, Univ. of Gene delivery WO 00/40723
Burlington, Vt. complex
Human zinc finger proteins used as a delivery vehicle for nucleic acids larger than 50 kilobases.
Victoria Univ. Nucleic acid WO 00/40751
Manchester, UK detection
Determining the specific sequence of nucleic acids using hybridization reactions and chromophore detection.
Viromed Gene therapy WO 00/40737
Seoul, S. Korea vector
Vectors with human cytomegalovirus intermediate early gene promoters and 5' untranslated regions; for gene therapy.
Washington Univ. DNA virus WO 00/40760
St. Louis detection
Cells transformed with silent inducible viral replicons encoding a recombinant protein; for DNA virus detection.
Xencor G-CSF mutants WO 00/40728
Pasadena, Calif.
Nucleic acids encoding G-CSF mutants having granulopoietic activity, encoded growth factors.
ZymoGenetics Soluble TNF WO 00/40716
Seattle receptor peptides
Soluble, secreted tumor necrosis factor (TNF) receptor polypeptides, encoding genes; for modulating B cells.
-Compiled by Chester Bisbee