September 21 (WO)
Alphagene WO 00/55375
Secreted proteins
Woburn, Mass.
Secreted proteins, encoding gene sequences; for diagnostics and therapeutics.
Amersham Pharmacia Biotech WO 00/55363
Gene expression patterns
Amersham, UK
Rapid and efficient analysis of differential gene expression patterns in biological systems.
Amersham Pharmacia Biotech WO 00/55364
Genetic analysis
Little Chalfont, UK
Whole genome analysis using terminal restriction site profiling arrays.
Aventis Pasteur WO 00/55326
Chlamydia vaccines
Toronto, Ont.
Chlamydia membrane protein antigens, encoding gene sequences; for vaccines.
Biosyn WO 00/55192
Cancer diagnostics
Felbach, Germany
Nucleic acid sequences encoding hemocyanin, fragments, and domains, encoded proteins, fusions; for cancer diagnostics.
Brigham & Women's Hosp. WO 00/54580
Leukotriene receptor transgenics
Boston
Transgenics having the human leukotriene B4 receptor gene inserted into their leukocytes; for overexpression.
Bristol, Univ. of WO 00/55330
Fatty acid saturation
Bristol, UK
Polyunsaturated fatty acid elongase from C. elegans, encoding gene; for modulating fatty acid saturation levels.
British Columbia, Univ. of WO 00/55318
Cholesterol level modulation
Vancouver, B.C.
ABC1 nucleic acids, encoded proteins; for diagnosing and controlling abnormal cholesterol regulation.
California, Univ. of WO 00/55367
Melanoma detection
Oakland, Calif.
Nucleic acid probes to a chromosomal region that is amplified in melanomas; for diagnosis.
Cambia Biosystems WO 00/55333
_-glucuronidase genes
Bellevue, Wash.
Microbial _-glucuronidase genes, encoded proteins; for polysaccharide modification.
Chicago, Univ. of WO 00/54574
Recombination stimulation
Chicago
Chemical and physical treatments that stimulate recombination; for modifying phenotypes.
Children's Hosp. WO 00/54796
Antiangiogenic peptides
Boston
Antiangiogenic peptides that inhibit endothelial cell proliferation.
Chiron WO 00/54813
Eye disease gene therapy
Emeryville, Calif.
Recombinant adeno-associated virus vectors for treating or preventing diseases of the eye.
Chiron WO 00/55343
Retroviral vector production
Emeryville, Calif.
Retroviral vector producing cells having multiple stably integrated copies and secreting multiple infectious viruses.
Columbia Univ. WO 00/55310
Tetracycline-controlled transactivator
New York
Protein Translation Peptide Elongation Factor-1 a promoter; for making a reverse tetracycline controlled transactivator.
Connaught Labs WO 00/55191
Hemophilus adhesin proteins
Toronto, Ont.
Recombinant Hemophilus influenzae adhesin proteins, encoding gene sequences; for diagnostics.
Corixa WO 00/55194
Tuberculosis antigens
Seattle
Mycobacterium tuberculosis antigens, fragments, encoding genes; for tuberculosis diagnostics and therapeutics.
Dana-Farber Cancer Inst. WO 00/55335 & 55378
Pseudotyped lentiviral vectors
Boston
Pseudotyped lentiviral vectors; for high quantity screening of specific targets from desired cells.
Devgen WO 00/54815
C. elegans disease models
Zwijnaarde, Belgium
Expression of genes in C. elegans excretory cells using the UL6 gene promoter; for disease modeling.
Du Pont WO 00/55311
Gene modification
Wilmington, Del.
Homologous recombination methods using selectable markers; for gene modification.
Eos Biotech WO 00/55373
Destructive macrophage development
S. San Francisco
Identifying nucleic acids and expression profiles characteristic of destructive macrophage development.
Exelixis WO 00/55178
Tumor suppressor modulators
S. San Francisco
Insect p53 tumor suppressor genes, encoded proteins; for identifying modulators to control cancer.
Exelixis WO 00/55376
Biogenic amine receptors
S. San Francisco
Invertebrate biogenic amine receptors, encoding gene sequences; for identifying therapeutic modulators.
Genentech WO 00/55319
Antitumor proteins
S. San Francisco
Identification of antitumor proteins, encoding gene sequences, antibodies; for inhibiting cancers.
Geron WO 00/55374
Pathogenic fungi therapy
Menlo Park, Calif.
Methods for inhibiting self-splicing of Group I introns; for inhibiting pathogenic fungi growth.
Guy, J., et al. WO 00/54595
Demyelination modulation
Gainesville, Fla.
Adeno-associated virus transfer of catalase or superoxide dismutase to optic nerves; for modulating demyelination.
Harvard Univ. WO 00/54730
Papillomavirus vaccines
Cambridge, Mass.
Production of soluble multimers of human papillomavirus L1 proteins in bacteria; for vaccines.
Hope Heart Inst. WO 00/55206
Stimulating endothelium
Seattle
Endothelial cell stimulation by a complex of fibronectin and vascular endothelial growth factor; for wound healing.
Human Genome Sciences WO 00/54651
TNF receptor-like genes
Rockville, Md.
Human tumor necrosis factor (TNF) receptor-like genes, encoded receptors, recombinant production methods.
Human Genome Sciences WO 00/55171, 55175-55177, 55198-55201, 55352, & 55371
471 secreted proteins
Rockville, Md.
471 human secreted proteins, encoding genes, antibodies, production methods; for diagnostics and therapeutics.
Human Genome Sciences WO 00/55173
Breast cancer genes
Rockville, Md.
Human breast and ovarian cancer-associated genes, encoded proteins, antibodies; for diagnostics and therapeutics.
Human Genome Sciences WO 00/55174
Prostate cancer genes
Rockville, Md.
Human prostate cancer-associated genes, encoded proteins, antibodies; for diagnostics and therapeutics.
Human Genome Sciences WO 00/55180
Lung cancer genes
Rockville, Md.
Human lung cancer-associated genes, encoded proteins, antibodies; for diagnostics and therapeutics.
Human Genome Sciences WO 00/55204
Interleukin-17 receptor-like protein
Rockville, Md.
Interleukin-17 receptor-like protein, encoding gene sequences; for identifying modulators.
Human Genome Sciences WO 00/55320
Pancreatic cancer genes
Rockville, Md.
Human pancreatic cancer-associated genes, encoded proteins, antibodies; for diagnostics and therapeutics.
Human Genome Sciences WO 00/55350
Human cancer genes
Rockville, Md.
Human cancer-associated genes, encoded proteins, antibodies; for diagnostics and therapeutics.
Human Genome Sciences WO 00/55351
Colon cancer genes
Rockville, Md.
Human colon cancer-associated genes, encoded proteins, antibodies; for diagnostics and therapeutics.
Hybritech WO 00/55308
Prostate diagnostics
San Diego
Detection of human kallikrein 2/protease inhibitor-6 complexes in prostate tumor tissue; for diagnosis.
Incyte Genomics WO 00/55332
Intracellular phosphorylation regulators
Palo Alto, Calif.
Regulators of intracellular phosphorylation, encoding genes, antibodies, modulators; for diagnostics and therapeutics.
Introgen Therapeutics WO 00/54839
Antitumor immune responses
Austin, Texas
Dendritic cells transformed with a self gene upregulated in tumor cells; for immune response induction.
Krebs Res. Ctr. WO 00/55316
Cell proliferation modification
Heidelberg, Germany
RNA polymerase 1 transcription factor, encoding gene sequences; for modifying cell proliferation rates.
LJL Biosystems WO 00/55372
Polymorphism detection
Sunnyvale, Calif.
Methods and devices for detecting nucleic acid polymorphisms using a luminescence-based assay.
Mass. Gen. Hosp. WO 00/54731 & 55181
Syndesmos
Boston
Syndesmos, a syndecan-binding protein, encoding gene; for modulating extracellular matrix adhesion and interactions.
McGill Univ. WO 00/55307
Full-length cDNA clones
Montreal, Que.
Increasing the processivity of DNA- and RNA-dependent polymerases; for generating full-length cDNA clones.
MRC (Med. Res. Counc.) WO 00/55183
Protein refolding
London
Refolding proteins having immunoglobulin G domains using chaperones and foldases.
Merck WO 00/55205
Psychiatric disorder therapy
Rahway, N.J.
Mouse serotonin 5-HT2c receptor isoforms; for identifying modulators to treat psychiatric disorders.
Michigan, Univ. of WO 00/55196
Protamine fragments
Ann Arbor, Mich.
Bioactive, low-toxicity protamine fragments; for neutralizing heparin and reducing bleeding.
Millipore WO 00/55185
Chromatographic separation
Bedford, Mass.
Metal-loaded ligand bound membranes; for metal ion affinity chromatographic separation of proteins.
Mitokor WO 00/55323
Organellar gene expression
San Diego
Differential expression of organellar gene products; for diagnosing and treating organellar-associated diseases.
NIH (Natl. Inst. Hlth.) WO 00/55207
Treating HIV infection
Bethesda, Md.
Bispecific fusion proteins having CD4 and Fv antibody domains; for treating HIV infection.
NIH (Natl. Inst. Hlth.) WO 00/55344
SV40 T antigen antisense
Bethesda, Md.
Adenoviral vector that expresses SV40 T antigen antisense RNA; for inducing apoptosis.
New York Blood Ctr. WO 00/55377
HIV therapeutics
New York
Screening of antiviral antibodies targeted to the HIV-1 gp41 core structure; for therapeutics.
North Carolina, Univ. of WO 00/55366
Electrochemical DNA detection
Chapel Hill, N.C.
Electropolymerizable film adhered to an electrode; for electrochemical detection of single-stranded DNA probes.
Novo Nordisk WO 00/55203
GLP-1 purification
Bagsvaerd, Denmark
Ion exchange chromatographic methods of separating glucagon-like peptide (GLP)-1 and related peptides.
Ortho-McNeil Pharma WO 00/55305
CD8+ cell isolation
Raritan, N.J.
Isolation of CD8+ cells using antibodies that do not activate these cells, antibodies.
Oxford Biomedica WO 00/55341
Viral vector production
Oxford, UK
Viral vector production system for use in making viral particles for treating and preventing viral infection.
Paradigm Genetics WO 00/55346
Gene knock-out libraries
Res. Triangle Park, N.C.
Facilitated site-directed homologous recombination for rapid and high volume production of gene knock-out libraries.
Pasteur Inst. WO 00/55362
Tuberculosis vaccination detection
Paris
Probes and antibodies for differentiating between vaccination and infection by Mycobacteria tuberculosis.
Pennsylvania, Univ. of WO 00/55342
AAV gene therapy vectors
Philadelphia
Methods of producing helper-free recombinant adeno-associated viruses (AAV); for gene therapy.
Perkin-Elmer WO 00/55368
Multiplex sequence detection
Foster City, Calif.
Nucleic acid probes having tags and mobility modifiers; for multiplex nucleic acid detection.
Photocure WO 00/54802
Antigen internalization
Oslo, Norway
Photochemical internalization of antigens in antigen-presenting cells; for surface presentation and vaccines.
Phylogeny WO 00/54814
Oncogenic transformation control
Columbus, Ohio
Identification of Hsp72 gene expression modulators; for affecting oncogenic transformation.
Pierre Fabre Medicament WO 00/55317
Brain cell protein
Boulogne-Billancourt, France
Brian cell surface expressed protein, encoding gene; for finding modulators and treating CNS diseases.
Pro-Virus WO 00/55306
CNS stem cell implants
Gaithersburg, Md.
Stem cells isolated from the central nervous system (CNS) and then immortalized; for implants.
Proteotech WO 00/55187
Alzheimer's therapeutics
Kirkland, Wash.
P400, a _-amyloid binding protein from serum; for Alzheimer's diagnostics and therapeutics.
Regeneron Pharma WO 00/55193
Cerberus-related proteins
Tarrytown, N.Y.
Cerberus-related protein, encoded proteins, probes; for identifying modulators.
Romagnolo Oncology Inst. WO 00/55360
DNA sequence alterations
Forli, Italy
Detecting DNA sequence alterations using endonuclease cleavase 1 and internal labelling of DNA fragments.
Sankyo WO 00/55334
Virus activating protease
Tokyo
Virus activating protease, encoding gene sequences, variants; for infectious disease therapeutics.
Schackert, H.K., et al. WO 00/55361
Identifying organisms
Dresden, Germany
Primers and hybridization probes for PCR identification of organisms using comparative genetic analysis.
SmithKline Beecham WO 00/55202
Frazzled proteins
Philadelphia
Frazzled proteins, encoding gene sequences; for finding modulators and treating immune system diseases.
SmithKline Beecham WO 00/55327
Identified proteins
Rixensart, Belgium
Identified proteins, encoding gene sequences, recombinant production methods; for diagnostics and therapeutics.
Stanford Univ. WO 00/55369
Mismatch repair detection
Palo Alto, Calif.
Screening for DNA sequence variations by placing them in the bacterial MRD gene and measuring colony growth.
Stanford Univ. WO 00/55620
Neurodegeneration therapeutics
Palo Alto, Calif.
Trangenics having adult onset neurodegenerative phenotype; for identifying therapeutics.
Takeda Chemical WO 00/55197
Cancer diagnostics
Osaka, Japan
Secretory proteins, encoding gene sequences, fragments, antibodies; for cancer diagnostics and therapeutics.
Tennessee, Univ. of WO 00/55312
Gene expression patterns
Knoxville, Tenn.
Temporally ordered panels of cDNA libraries from human microclones; for determining gene expression patterns.
Tepnel Medical WO 00/55365
Target detection
Manchester, UK
Target molecule detection using enzymatically catalyzed signal amplification of target-associated structures.
Texas, Univ. of WO 00/55345
Cytokine tumor therapy
Austin, Texas
Insect cells containing baculoviruses expressing cytokines; for direct injection into tumors.
Thomas Jefferson Univ. WO 00/55169
T-cell malignancy gene
Philadelphia
TCL-1b gene located at the chromosome 14q32.1 locus; for detecting and treating T-cell malignancies.
United Therapeutics WO 00/55314
Inhibiting endothelin-1 synthesis
Washington
Human preproendothelin-1 mRNA sequences; for making antisense that inhibits endothelin-1 synthesis.
Virginia Commonwealth Univ. WO 00/55304
CHC biosynthetic gene cluster
Richmond, Va.
CHC biosynthetic gene cluster; for transfection and metabolism modulation.
Vistagen WO 00/55370
Gene expression patterns
Mountain View, Calif.
Identifying nucleic acid sequence using a limited number of probes; for measuring gene expression patterns.
Wakamoto Pharma WO 00/55186
Flavobacterium antibiotic
Tokyo
Gram-positive antibiotic isolated from Flavobacteria strains, production methods.
Washington Univ. WO 00/55321
Axon growth guidance
St. Louis, Mo.
Vertebrate slit protein, encoding gene sequences, production methods; for repulsive guidance of axon growth.
Wisconsin, Univ. of WO 00/55208
Chimeric neurotoxin
Madison, Wis.
Chimeric toxin having botulinim neurotoxin heavy chain and non-clostridial toxin moieties; for neurological disorders.
Xenogen WO 00/54581
Sepsis animal model
Alameda, Calif.
Labeling sepsis-causing microorganisms with a reporter gene; for monitoring sepsis progression in animal models.
Xoma Technol. WO 00/55322
Recombinant protein production
Berkeley, Calif.
Methods for more efficient production of recombinant proteins from bacterial cells.
ZymoGenetics WO 00/55321
Mouse interferon-a
Seattle
Mouse interferon-a, encoding gene sequences; for immune system diagnostics and therapeutics.