December 20 (EP); December 14 & 21 (WO)
Aberdeen, Univ. of WO 00/75175
Fibrin fragment E binding
Aberdeen, U.K.
Peptides, analogs, and antibodies that modulate the binding of fibrin fragment E to cell receptors.
Active Biotech WO 00/75187
Integrin heterodimer
Lund, Sweden
Integrin heterodimer, its a subunit; for marking cells and developing therapeutics and vaccines.
Alabama, Univ. of WO 00/75292
Cancer gene therapy
Birmingham, Ala.
Herpes simplex vectors encoding anti-cancer agents such as IL-12 and GM-CSF; for cancer treatment.
Angeletti Inst. Molec. Biol. Res. WO 00/75354
Long-term interferon
Pomezia, Italy
Helper-dependent adenoviral vectors encoding interferon; for long-term, repeated administration to patients.
Aventis WO 00/75309
Spliceosome protein
Frankfurt, Germany
Spliceosome protein associated with the U11/U12 snRNP complex of the U12 spliceosome; for autoimmunity diagnosis.
Aventis Pasteur WO 00/75304
Immunostimulant oligos
Lyon, France
Oligonucleotides having all their cytosines methylated; for stimulating human immune cells.
Babraham Inst. WO 00/75311
Nematode nicotinic receptor
Cambridge, U.K.
Recombinant nematode nicotinic receptor, encoding gene on chromosome 1; for identifying modulators.
Becton Dickinson EP 1 061 134
Hemochromatosis gene alleles
Franklin Lakes, N.J.
Oligonucleotides for the amplification and detection of hemochromatosis gene variations.
Bioinnovation WO 00/74724
Gene therapy agents
Epsom, U.K.
Gene therapy agents having therapeutic gene, cytokine, and liposome moieties; for delivery vehicles.
Biosearch Technol. WO 00/75378
Fluorescent gene probes
Novato, Calif.
Fluorescent energy transfer probes having stabilized conformations; for gene sequencing.
Biovector Therapeutics WO 00/75181
HIV vaccines
Labege, France
Protein fragments from the HIV Nef protein having multiple epitopes, production methods; for vaccines.
Biovector Therapeutics WO 00/75336
Papillomavirus vaccines
Labege, France
Protein fragments from E6 and E7 human papillomavirus; for vaccines.
British Columbia, Univ. of WO 00/75334
Apoptosis inhibition
Vancouver, B.C.
Inhibition of apoptosis by administering the E3/6.7K protein from adenovirus.
Burnham Inst. WO 00/75174
Heart homing peptides
La Jolla, Calif.
Heart homing peptides, therapeutic conjugates; for treating atherosclerosis and restenosis.
Cambridge Life Sciences WO 00/75360
Enzyme presence detection
Ely, U.K.
Methods for detecting the presence of a given enzyme based on the enzyme-induced degradation of a polymer film.
Canadian Natl. Res. Counc. WO 00/75286
Cancer chemotherapeutic assay
Ottawa, Ont.
3-dimensional in vitro model organoids of cancer cells; for testing chemotherapeutics.
Cancer Res. Camp. Technol. WO 00/74722
Polymer coated viruses
London
Modifying biological elements such as viruses by coating them with multivalent polymers having reactive groups.
Cedars-Sinai Med. Ctr. WO 00/75326
Suppressor of cytokine signalling-3 promoter
Los Angeles
Suppressor of cytokine signalling-3 promoter, vector with a structural gene operatively linked to the promoter.
Cell Genesys WO 00/75299
Cloning large genome segments
Foster City, Calif.
Hybrid yeast-bacteria cloning system; for using homologous recombination to clone large-sized nucleic acid sequences.
CNRS (Natl. Ctr. Sci. Res.) WO 00/75290
Maintaining stem cells
Paris
Use of a cellular development inhibitor to maintain human stem cells in an undifferentiated, but proliferative, state.
Chicago, Univ. of WO 00/75324
Prion-like genes
Chicago
Recombinant prion-like genes, encoded proteins, recombinant production methods; for diagnostics and therapeutics.
Chugai Res. Inst. Molec. Med. WO 00/75314
Hemopoietin receptor
Ibaraki, Japan
Hemopoietin receptor protein, encoding gene sequences; for modulator assays and developing immunotherapeutics.
Cold Spring Harbor Labs WO 00/75339
Finding PTP substrates
Cold Spring Harbor, N.Y.
Catalytically impaired substrate trapping mutant protein tyrosine phosphatases (PTP) that retain binding abilities.
Columbia Univ. WO 00/75278
Apoptosis inhibition
New York
Protein ligand for p75NTR receptor associated with a cell death executor, encoding gene; for apoptosis inhibition.
CuraGen WO 00/75321
NOVX proteins
New Haven, Conn.
NOVX proteins, encoding gene sequences, variants, antibodies; for diagnostics and therapeutics.
CuraGen WO 00/75366
Transcription-based gene mapping
New Haven, Conn.
Mapping gene response patterns in hybrid cells containing expressed genes located on exogenous chromosomal segments.
Cytoclonal Pharma WO 00/75190
Lung carcinoma antibodies
Dallas
Hybridomas secreting monoclonal antibodies against epitopes in non-small cell lung carcinoma proteins; for diagnostics.
Dana-Farber Cancer Inst. WO 00/74725
Hypoxia response modifiers
Boston
Identification of compounds that modify transcriptional responses to hypoxia; for diagnostics and therapeutics.
Du Pont WO 00/75340
Magnesium chelatase
Wilmington, Del.
Magnesium chelatase, encoding gene sequences, chimeric genes, antisense; for altering enzyme levels in cells.
Duke Univ. WO 00/74728
Antibody fragment isolation
Durham, N.C.
Isolated B1 domain polypeptide of bacterial protein G; for isolating Fab fragments of immunoglobulin G.
Edwards Life Sciences WO 00/75329
Angiogenesis inhibition
Irvine, Calif.
Chimeric therapeutics having angiogenesis inhibitor and targeting moieties; for treating cardiovascular disease.
Genentech WO 00/75316 & 75327
Antitumor agent screens
S. San Francisco
Cancer-associated proteins, encoding gene sequences, fusions; for screening antitumor agents.
Genentech WO 00/75317
Amplified genes in cancer
S. San Francisco
Genes that are amplified in cancer cells, encoded proteins, fusions; for diagnostics and therapeutics.
Gladstone Inst. WO 00/74726
p53-mediated apoptosis inhibition
San Francisco
Prevention of p53-mediated apoptosis; for treating neurodegenerative diseases such as Alzheimer's.
Glaxo WO 00/75310
IL-1 receptor-associated kinase
Greenford, U.K.
Interleukin-1 receptor-associated kinase-3, encoding gene, variants, antibodies, modulators; for therapeutics.
Hillen, W. WO 00/75362
Finding transcription factors
Utienreuth, Germany
Vector with indicator genes controlled by gene sequences to which transcription factors bind; for finding these factors.
Hoechst Marion Roussel WO 00/75305
Antifungal assay
Puteaux, France
Candida albicans yeast genes, analogs, encoded proteins, preparation methods; for finding antifungals.
Human Genome Sciences WO 00/75163
Angiogenic proteins
Rockville, Md.
Angiogenic proteins, encoding genes, antibodies, modulators, production methods; for diagnostics and therapeutics.
Human Genome Sciences WO 00/75375, 76530, 76531, 77021-77023, 77173, 77197, 77237, 77255 & 77256
503 Secreted Proteins
Rockville, Md.
Human secreted proteins, encoding genes, antibodies; for therapeutics.
Illumina WO 00/75373
Decoding random arrays
San Diego
Methods and compositions for combinatorial decoding of random nucleic acid arrays; for gene identification.
Immunex WO 00/75323
Angiogenesis inhibitor
Seattle
Tek antagonists; for inhibiting angiogenesis in tumors and eyes.
Incyte Genomics WO 00/75298
Disease treatment proteins
Palo Alto, Calif.
Disease detection and treatment proteins, encoding genes, fragments, antibodies, microarrays; for therapeutics.
Incyte Genomics WO 00/75318
Phospholipid transfer protein
Palo Alto, Calif.
Phospholipid transfer protein, encoding gene sequences; for diagnostics and therapeutics.
Isis Pharma WO 00/74687
T cell activation antisense
Carlsbad, Calif.
Antisense modulation of B7 protein expression; for affecting T cell activation and treating immune system disorders.
Japan Sci. & Technol. WO 00/75301
Gene regulator binding sites
Saitama, Japan
Searching the internal structure of enhancers and promoters; for finding binding sites for gene regulators.
Jenapharm WO 00/74723
Prostate hyperplasia therapy
Jena, Germany
Agents that cause apoptosis in benign hyperplastic prostate tissue; for therapeutics.
Johns Hopkins Univ. WO 00/75661
Synaptogenesis assay
Baltimore
Methods for identifying compounds that affect synaptogenesis by transfecting Narp genes into neurons.
Kern, F. WO 00/75180
Human CMV vaccines
Berlin
Peptide fragments from 1E-1 and pp65 proteins from human cytomegalovirus (CMV); for vaccines.
Kyowa Hakko Kogyo WO 00/75313
Rheumatoid arthritis diagnosis
Tokyo
Measurement of differential expression of rheumatoid arthritis-associated genes in leukocytes; for diagnosis.
Lexicon Genetics WO 00/75320
Signal transduction genes
The Woodlands, Texas
Signal transduction pathway genes, encoded proteins, antibodies; for diagnostics and therapeutics.
Lorantis WO 00/74706
Hedgehog protein therapeutics
Cambridge, U.K.
Therapeutic use of an inhibitor of hedgehog or a hedgehog-related signalling pathway for cancers, transgenics.
Mass. Inst. Technol. WO 00/75161
Apoptosis modulator screens
Cambridge, Mass.
Compositions and methods for screening and identifying apoptosis modulators.
MRC (Med. Res. Counc.) WO 00/75346
Chaperone protein fusions
London
Fusion proteins containing a chaperone polypeptide fragment, encoding gene sequences; for protein transport.
Merck WO 00/75160
Apoptosis modulator assays
Rahway, N.J.
Recombinant cells expressing fluorescence energy transfer reporter polypeptides; for finding apoptosis modulators.
Miami, Univ. of WO 00/75294
Diabetes predisposition diagnosis
Miami
Glycogenin, glycogenin pseudogenes, expression detection methods; for diagnosing a predisposition to type 2 diabetes.
Michigan, Univ. of WO 00/75279
Age-related gene regulation
Ann Arbor, Mich.
Gene regulatory elements that affect expression in an age-related or liver-specific manner.
Millennium Pharma WO 00/75358
TOLL family proteins
Cambridge, Mass.
TOLL protein family members, encoding genes, fusions, antibodies, transgenics; for diagnostics and therapeutics.
Mirus WO 00/74635
Single-stranded genes
Madison, Wis.
Generation and delivery of single-stranded DNA capable of expressing a gene; for gene therapy.
Mosaic Technol. WO 00/75374
Solid phase amplification
Waltham, Mass.
Solid phase multi-stage bridge amplification using recovered single-stranded nucleic acid molecules.
NIH (Natl. Inst. Hlth.) WO 00/75337
Hepatitis C model virus
Bethesda, Md.
Infectious cDNA clone of GB virus B; for studying hepatitis C virus biology and developing therapeutics and vaccines.
NIH (Natl. Inst. Hlth.) WO 00/75338
Hepatitis C virus strain
Bethesda, Md.
Cloned genome of infectious hepatitis C virus of genotype 2a, encoded proteins; for identifying antivirals.
NIH (Natl. Inst. Hlth.) WO 00/75352
Hepatitis C virus chimeras
Bethesda, Md.
Chimeric hepatitis C-bovine diarrhea viruses; for hepatitis antibody neutralization assays and vaccine development.
NeoRx WO 00/75333
Streptavidin fusions
Seattle
Vectors expressing genomic streptavidin fusions with single chain antibodies; for diagnostics and targeting agents.
Nippon Inst. Biol. Sci. WO 00/75342
Gene insertion vectors
Tokyo
Plasmid vector containing an integrase gene whose expression is directed by regulatory sequences; for gene insertion.
Novartis WO 00/75291
Engrafting CD34+ cells
Vienna, Austria
CD34+ hematopoietic cells modified to overexpress BCL-xL; for increased cell viability and engraftment ability.
Oncodia WO 00/75287
Cancer chemotherapeutic assay
Zurich, Switzerland
Long-term cell culture of human carcinomas; for diagnostics and drug screening.
Osteopharm WO 00/75185
Bone stimulating factors
Oakville, Ont.
Bone stimulating factors, encoding gene sequences, methods of preparation; for bone growth modulation.
Oxford BioMedica WO 00/75370
Inhibitory RNA molecules
Oxford, U.K.
In vivo selection methods for identifying inhibitory RNA molecules that affect gene expression.
Pennsylvania, Univ. of WO 00/75353
Recombinant virus production
Philadelphia
Methods for producing recombinant viruses that require helper viruses; for making adenovirus gene therapy vectors.
Pharmacia & Upjohn WO 00/75328
Sel-10 proteins
Kalamazoo, Mich.
Human sel-10 proteins, encoding genes, splice variants; for diagnostics and therapeutics.
Regen Therapeutics WO 00/75173
Colostrinin peptides
London
Amino acid sequences of several peptides present in Colostrinin; for treating immune and CNS diseases.
Regeneron Pharma WO 00/75319
Modified Flt1 receptor
Tarrytown, N.Y.
Modified chimeric Flt1 receptor; for improved pharmacokinetics in decreased vascular permeability.
RIKEN EP 1 061 130
RNA polymerase accelerators
Wako, Japan
Polyamine-based compounds having accelerating activity for RNA polymerases; for increased transcription.
Rutgers Univ. WO 00/75289
Targeted gene integration
New Brunswick, N.J.
Transposon/transposase system for the targeted integration of heterologous genes into the genome.
Salk Inst. Biol. Studies WO 00/75325
Affecting Fas-mediated cell death
La Jolla, Calif.
Lifeguard genes, encoded proteins, variants; for finding modulators to affect Fas-mediated cell death.
Samsung Electronics WO 00/75372
Preparing microarrays
Kyunggi-do, S. Korea
Methods for preparing peptide nucleic acid probes on microarrays using polymeric a photoacid generator.
Sankyo WO 00/75315
Liver-permeating drug screen
Tokyo
Protein that is useful in screening a liver-permeating drug and constructing artificial livers.
Sardegna Zootechnol. Inst. WO 00/74477
Transgenic production methods
Olmedo, Italy
Transfer of somatic cells into heated, enucleated metaphase II oocytes; for making transgenics.
Seattle Genetics WO 00/75348
CD40 antibodies
Bothell, Wash.
Recombinant anti-CD40 antibodies; for treating cancer and immune system diseases.
Skerra, A. WO 00/75308
Digoxigenin ligands
Freising, Germany
Muteins of bilin-binding protein that bind digoxigenin, fusions, antibodies.
SmithKline Beecham WO 00/75168
Urotensin-II receptor
Philadelphia
Mouse urotensin-II receptor, encoding gene, recombinant production methods; for diagnostics and therapeutics.
SmithKline Beecham WO 00/75169
Antibacterial development
Philadelphia
Crystal structure of E. coli FabH; for finding inhibitors and developing antibacterials.
SmithKline Beecham WO 00/75280
FRZB protein family
Philadelphia
Member of the FRZB protein family, encoding gene sequences; for diagnostics and therapeutics.
SmithKline Beecham WO 00/75357
Antibacterial screens
Philadelphia
Bacterial aroA polypeptides, encoding gene sequences, recombinant production methods; for antibacterial screens.
Syngenix WO 00/75351
Heterologous gene expression
Heydon near Royston, U.K.
Simian immunodeficiency virus-based packaging-deficient vectors; for expressing heterologous genes.
Texas, Univ. of WO 00/74485
Treating estrogen-dependent cancer
Austin, Texas
Estrogen receptor site-specific hammerhead ribozymes; for treating estrogen-dependent cancer.
Texas, Univ. of WO 00/74704
TFIIA-related transcription factors
Austin, Texas
Transcription factors related to TFIIA, fusions, modulators, transgenics; for diagnostics and therapeutics.
Thomas Jefferson Univ. WO 00/75376
Hepatitis antivirals
Philadelphia
Cell line stably transfected with hepatitis C virus; for identifying antiviral agents.
Tosoh WO 00/75371
Potentiated amplification
Yamaguchi, Japan
Potentiated methods for amplifying specific nucleic acid molecules using cycles of RNA and DNA amplification.
Transgene WO 00/74629
Antiviral therapy vectors
Strasbourg, France
Vector with host cell-specific regulatory elements linked to coding sequences for MIP chemokines; for antiviral therapy.
Tranxenogen WO 00/75300
Bird transgenics
Shrewsbury, Mass.
Making transgenic birds using non-viral DNA to transfect the blastoderm of a fertilized egg; for making foreign proteins.
Whitehead Inst. Biomed. Res. WO 00/75188
Protein translocation
Cambridge, Mass.
Methods for measuring protein translocation between the cytoplasm and the plasma membrane.
Yale Univ. WO 00/75184
Protein degradation
New Haven, Conn.
Various methods for causing target protein degradation using the SCF complex; for treating cancer.
Yissum Res. & Develop. WO 00/75312
Rheumatoid arthritis splice variant
Jerusalem
CD44 splice variant found in synovial cells of rheumatoid arthritis patients; for diagnosis and therapy.