May 2 (EPO), April 26 (WO); May 2 (GB)
Abbott Labs WO 01/29264
Tumor cell detection
Abbott Park, Ill.
Nucleic acid primers and probes for amplification to detect CK19 target tumor-related gene sequences.
Advanced Cell Technol. WO 01/29206
Producing progenitor cells
Worcester, Mass.
Methods for producing differentiated progenitor cells and lineage-defective embryonic stem cells.
Affymetrix WO 01/29259
Allele identification
Santa Clara, Calif.
Genotyping using primer extension amplification with sequence-coded identity tags; for finding allele frequency.
Affymetrix WO 01/29267
Identifying maintenance genes
Santa Clara, Calif.
Methods for identifying maintenance genes by comparing expression levels in several samples.
Agilent Technol. GB 2 355 716
Array fabrication
Santa Clara, Calif.
Modified inkjet printing system used to fabricate polynucleotide arrays.
Agouron Pharma EP 1 096 014
Checkpoint protein kinase
La Jolla, Calif.
Catalytic domain of the human cell cycle checkpoint protein kinase Chk1, encoding gene; for finding inhibitors.
Akzo Nobel WO 01/29081
Autoimmunity immunotherapy
Arnhem, Netherlands
Modified peptides and peptidomimetics for use in immunotherapy of autoimmune diseases.
Amersham Pharmacia Biotech GB 2 355 717
DNA isolation
Amersham, UK
Isolation of DNA or cell nuclei in micro-channels in an apparatus with a rotatable disk.
Arkansas, Univ. of WO 01/29056
Breast cancer therapeutics
Little Rock, Ark.
TADG-15 protein, encoding gene sequences; for finding inhibitors and developing breast cancer therapeutics.
Artemis Pharma WO 01/29208
Inactivating genes
Cologne, Germany
Gene trapping construct that causes conditional mutations in genes; for mutational inactivation of cellular genes.
Avatar Medical WO 01/29247
Stabilized proteins
Newark, N.J.
Methods for mutagenizing and controlled cross-linking of proteins; for stabilization.
Aventis Pharma EP 1 096 012
ABC1 gene
Antony, France
Human ABC1 gene sequences, encoded protein; for developing cholesterol metabolism diagnostics and therapeutics.
Aventis Pharma WO 01/29234
Controlling protein synthesis
Antony, France
Insertion of untranslated regions into an mRNA sequence; for self-cleavage to control protein synthesis.
BASF WO 01/29227
Lipid body lipoxygenase
Ludwigshafen, Germany
_-barrel of lipid body lipoxygenase, encoding gene; for developing therapeutics for lipid metabolism control.
Biomerieux WO 01/28683 & 28685
Amplification test strips
Hazelwood, Mo.
Disposable test strips for devices to perform nucleic acid amplification reactions.
Canji WO 01/28569
Gene delivery vehicles
San Diego
Gene delivery vehicles having the targeting moiety attached by transition metal ions; for ease of moiety attachment.
Case Western Res. Univ. WO 01/29269
IBD gene expression profiles
Cleveland, Ohio
Gene expression profiling of patients with inflammatory bowel disease.
Colorado, Univ. of WO 01/29062
Modulating cell phenotype
Boulder, Colo.
Modulating cell phenotype using genes encoding proteins with CREB biological activity; for treating diabetes and obesity.
Compugen WO 01/29215
N-CAM homologs
Tel Aviv, Israel
Neural cell adhesion molecule homologs, splice variants; for developing diagnostics and therapeutics.
CuraGen WO 01/29071
Obesity-associated genes
New Haven, Conn.
Genes associated with obesity, differential expression assays for diagnosis and modulator screens.
CuraGen WO 01/29217
Human proteins
New Haven, Conn.
Human proteins, encoding gene sequences, antibodies, variants, mutants, fragments; for developing therapeutics.
CuraGen WO 01/29268
Interacting gene products
New Haven, Conn.
Methods for identifying interacting gene products, such as members of protein-protein complexes.
Dalhousie Univ. WO 01/29243
Transferring spliced proteins
Halifax, N.S.
Methods and vectors for producing and transferring trans-spliced peptides that form a complete protein.
Digital Gene Technol. WO 01/29179
Neuromodulator regulated genes
La Jolla, Calif.
Genes and proteins related to neural disease; for regulation by neuromodulators.
Du Pont WO 01/29261
Gene expression profiling
Wilmington, Del.
Methods for high-density microarray-mediated comprehensive gene expression profiling.
Emory Univ. WO 01/29235
Silenced methylated gene
Atlanta
TMS1 gene that is transcriptionally silenced by methylation; for diagnostics and therapeutics.
Enchira Biotech WO 01/29211 & 29212
Directed gene evolution
The Woodlands, Texas
Directed evolution of whole genomes and large DNA sequences by random chimeragenesis on transient templates.
European Molec. Biol. Lab WO 01/29231
Genetic switches
Heidelberg, Germany
Genetic switches that use a Cre recombinase; for making transgenics.
Genaissance Pharma WO 01/28995 & 29176
Cholinergic receptor SNPs
New Haven, Conn.
Polymorphisms in the cholinergic receptor muscarinic 3 and 5 genes; for population genotyping.
Genaissance Pharma WO 01/29263
Serotonin receptor SNPs
New Haven, Conn.
Polymorphisms in the serotonin receptor gene; for population genotyping.
Genena WO 01/29210
Connecting gene sequences
Moshav Herut, Israel
Methods for establishing connections between the regulatory region of genes and various structural genes.
Genentech WO 01/29070
T cell differentiation
S. San Francisco
Type 1 cytokine receptor, encoding gene sequences, modulators; for modifying T cell differentiation.
Genset WO 01/29257
Genetic cluster analysis
Paris
Methods for genetic cluster analysis using DNA fingerprinting in patient populations.
Ghent Univ. WO 01/29251
Neurofibromatosis 1 gene mutations
Ghent, Belgium
Enhanced mutation analysis of the neurofibromatosis 1 gene; for diagnostic and therapeutic development.
Ghent Univ. WO 01/29254
Blepharophimosis syndrome gene
Ghent, Belgium
Identification of a gene disrupted by a balanced chromosomal translocation in blepharophimosis syndrome.
Glaxo WO 01/29255
Cephalic pain diagnosis
Greenford, UK
Genotyping DNA sequences in the insulin receptor gene region; for diagnosing susceptibility to cephalic pain.
Heska WO 01/29078
Mite protein production
Ft. Collins, Colo.
Production of mite group 1 proteins in methylotrophic yeast or E. coli; for vaccines.
Hisamitsu Pharma WO 01/29244
Nucleic acid delivery
Saga, Japan
Nucleic acid transporter made from a protein containing diaminobutyric acid; for high level transgene expression.
Histatek WO 01/29069
Inflammatory agent
San Francisco
N-formyl peptide receptor complex with a G-protein kinase signal pathway modification agent; for inflammation.
Human Genome Sciences WO 01/29063
Death domain receptor
Rockville, Md.
Death domain-containing receptors, encoding gene sequences, antibodies, recombinant production methods.
Human Genome Sciences WO 01/29564
Protein tyrosine kinase receptor
Rockville, Md.
Protein tyrosine kinase receptor, encoding gene, antibodies production methods; for diagnostics and therapeutics.
Icos EP 1 096 016
Platelet-activating factor
Bothell, Wash.
Platelet-activating factor acetylhydrolase, encoding gene sequences; for developing inflammation therapeutics.
Iowa, Univ. of WO 01/29216
Sarcospan-deficient mice
Iowa City, Iowa
Sarcospan-deficient mice; for modeling clinical disorders associated with adipose tissue deposition.
Isis Pharma WO 01/29057
bcl-6 antisense
Carlsbad, Calif.
Antisense modulation of bcl-6 expression; for treating diseases associated with bcl-6 expression.
Isis Pharma WO 01/29175
fra-1 antisense
Carlsbad, Calif.
Antisense modulation of fra-1 expression; for treating diseases associated with fra-1 expression.
Japan Sci. & Technol. WO 01/28321
Diabetes onset transgenics
Saitama, Japan
Transgenics having the imprinting gene Meg1/Grb10; for studying diabetes onset.
Johns Hopkins Univ. WO 01/29233
Chimeric immunogenic agents
Baltimore
Chimeric immunogenic compositions having heat shock protein and cytokine domains, encoding gene sequences.
Juvantia Pharma WO 01/29082
Variant adrenoreceptor
Turku, Finland
Variant adrenoreceptor, encoding gene, transgenics; for developing coronary vascular restriction therapeutics.
Kyowa Hakko Kogyo WO 01/29246
Antibody production
Tokyo
Process for producing antibodies in rat cells cultured in serum-free medium.
Leadd WO 01/29226
Apoptosis-inducing protein
Leiden, Netherlands
Apoptosis-inducing protein that affects tumor cells but not normal cells; for cancer developing therapeutics.
Lexicon Genetics WO 01/29084
Human proteins
The Woodlands, Texas
Human proteins, encoding gene sequences; for developing diagnostics and therapeutics.
Lexicon Genetics WO 01/29219
CUB domain protein
The Woodlands, Texas
Human CUB domain-containing protein, encoding gene sequences; for diagnostics and therapeutics.
Ludwig Inst. Cancer Res. WO 01/29220
MAGE antigenic peptides
New York
Antigenic peptides derived from MAGE-A12 polypeptides that are presented by HLA molecules; for cancer therapy.
Massachusetts, Univ. of WO 01/29058
RNA interference genes
Boston, Mass.
Genes involved in the double-stranded RNA interference pathway; for developing modulators.
Max Planck Inst. WO 01/29068
Potassium ion channel
Berlin
Human potassium ion channel, encoding gene, antisense; for developing cancer and neural disease therapeutics.
McGill Univ. WO 01/29266
Spastin gene mutations
Montreal
Isolated spastin genes and encoded proteins, fragments, altered forms; for neurodegenerative disease diagnosis.
MRC (Med. Res. Counc.) WO 01/29236
Membrane protein expression
London
Expression system for membrane proteins; for isolation and purification.
Millennium Pharma WO 01/29088
Therapeutic proteins
Cambridge, Mass.
Therapeutic and diagnostic proteins, encoding gene sequences, transgenics, antibodies.
Millennium Pharma WO 01/29199
Cyclic nucleotide phosphodiesterase
Cambridge, Mass.
Human cyclic nucleotide phosphodiesterase, encoding gene; for diagnostics, therapeutics, and finding modulators.
Molecular Light Technol. Res. GB 2 355 791
RNA detection
Cardiff, UK
Detecting RNAs using oligonucleotide probes labelled with chemiluminescent molecules; for studying transcription.
Novo Nordisk Biotech WO 01/29222
Phospholipase A-like protein
Davis, Calif.
Phospholipase A-like protein, encoding gene sequences, production methods; for developing therapeutics.
Ohio State Univ. WO 01/29059
Group II intron insertion activity
Columbus, Ohio
Methods for analyzing the insertional capabilities of modified group II introns.
Orchid Biosciences WO 01/29262
Genotyping reagents
Princeton, N.J.
Oligonucleotides for determining the presence and identity of single nucleotide polymorphisms.
Osaka Univ. GB 2 355 718
Modified recombinase gene
Osaka, Japan
Modified Cre recombinase gene having codons used frequently in mammalian cells; for gene manipulation.
Panorama Res. WO 01/29225
Optimizing protein expression
Mountain View, Calif.
Optimizing the expression of heterologous proteins by selecting autonomously folding domains from cDNA libraries.
Peptide Solutions WO 01/29177
HIV vaccines
Columbia, Md.
Mutated forms of HIV-1 subtype D peptides having altered hydrophilic residues; for vaccines.
Pittsburgh, Univ. of WO 01/29218
Nuclear matrix proteins
Pittsburgh, Penn.
Nuclear matrix proteins from prostate tissue, encoding gene sequences; for developing diagnostics and therapeutics.
Prince Henry's Inst. Med. Res. WO 01/29079
Inhibin subunit fragments
Clayton, Australia
Immuno-interactive fragments of the aC subunit of inhibin; for therapeutic development.
Rigel Pharma WO 01/29072
Cell cycle-associated proteins
S. San Francisco
Cell cycle-associated proteins, encoding genes, antibodies, production methods; for affecting the cell cycle.
Scios WO 01/29232
Cloning proteolytic enzymes
Sunnyvale, Calif.
Functional cloning of genes encoding proteins and enzymes involved in proteolytic cleavage using caspase cassettes.
Shanghai Bio Road Gene Develop. WO 01/29075
G-protein activating protein
Shanghai, China
G-protein activating protein, encoding gene sequences, production methods; for therapeutic development.
Shanghai Bio Road Gene Develop. WO 01/29076
Human p24 protein
Shanghai, China
Human p24 protein, encoding gene sequences, production methods; for therapeutic development.
Shanghai Bio Road Gene Develop. WO 01/29077
Human _-microglobin regulatory factor
Shanghai, China
Human _-microglobin regulatory factor, encoding gene sequences, production methods; for therapeutic development.
Shanghai Bio Road Gene Develop. WO 01/29080
High mobility group protein
Shanghai, China
Human high mobility group protein 13, encoding gene sequences, production methods; for therapeutic development.
Shanghai Bio Road Gene Develop. WO 01/29228
Casein kinase
Shanghai, China
Human casein kinase, encoding gene sequences, production methods; for therapeutic development.
Shanghai Bio Road Gene Develop. WO 01/29229
Retinoblastoma binding protein
Shanghai, China
Human retinoblastoma binding protein, encoding gene sequences, production methods; for therapeutic development.
SmithKline Beecham WO 01/29089
Rat 7-transmembrane receptor
Philadelphia
Rat 7-transmembrane receptor, encoding gene sequences, recombinant production methods; for modulator screens.
SmithKline Beecham WO 01/29178
EPO primary response gene
Philadelphia
EPO primary response gene, encoded protein, recombinant production methods; for diagnostics and therapeutics.
SmithKline Beecham WO 01/29214
Colon tumor antigens
Rixensart, Belgium
Colon tumor-associated antigens, encoding gene sequences; for cancer diagnostics and therapeutics.
Speicher, M. WO 01/29252
Repeat-depleted DNA
Riemerling, Germany
Generating repeat-depleted DNA using amplification methods; for DNA array hybridization.
Speicher, M. WO 01/29253
Visualizing heterochromatin
Riemerling, Germany
Simultaneous visualization of eu- and heterochromatin; for diagnostics.
Taiho Pharma WO 01/29207
Uracil antibodies
Tokyo
Monoclonal antibodies to uracil; for immunological measurement of uracil and thymidine in samples.
Texas Biotech WO 01/29083
Adhesion proteins
Houston
Human and mouse adhesion proteins, encoding gene sequences; for developing therapeutics.
Transgene EP 1 096 018
Complementation cells
Strasbourg, France
Complementation cells containing an inducer or a repressor [in French].
Ventana Medical Systems WO 01/29265
Single gene copy detection
Tucson, Ariz.
Methods for detecting single gene copies in situ using brightfield microscopy and a chromogen molecule.
Welfide EP 1 096 017
Increasing protein production
Osaka, Japan
Increasing recombinant protein production from cell cultures using cobalt and molybdenum in the culture medium.
Wellcome Trust WO 01/29213
SIT4-associated proteins
London
Human SIT4-associated proteins, encoding genes; for diagnostics and therapeutics.
Yale Univ. WO 01/29249
DNA cloning constructs
New Haven, Conn.
Conjoined polynucleotide catalysts having at least two domains; for DNA cloning.
ZymoGenetics WO 01/29221
Signal sequence fusion proteins
Seattle
Fusion proteins having a signal sequence, encoding gene sequences, modulators; for developing therapeutics.
ZymoGenetics WO 01/29223
Membrane protein
Seattle
Type 1 membrane protein, encoding gene sequences, antibodies, affinity tag fusions; for cancer diagnosis.
ZymoGenetics WO 01/29224
Granulocyte peptide homolog
Seattle
Granulocyte peptide homolog, encoding gene sequences, fusions, chimeric affinity tags; for therapeutics.