Published May 12 & 19 (EPO); May 13 (WO)

BASF AG Tick-borne anti-Ludwigshafen, Germany thrombinA thrombin-inhibiting protein from ticks (Ixodoidea), MW26,000 Dalton, amino-acid sequences provided; "suitable forcombating diseases."

BASF AG Bug-borne anti- WO 93/92312Ludwigshafen, Germany thrombinA thrombin-inhibiting protein from kissing bugs (Reduvii); MW12,000 Dalton; sequences provided; "suitable for combatingdiseases."

Baxter Diagnostics Inc. Hepatitis C WO 93/9253Deerfield, Ill. epitopeAssay for detecting serum antibodies specific to hepatitis Cviral antigens utilizes 102 amino acids of non-structural gene3 epitopes.

Baylor Coll. of Med. Myogenic vector WO 93/9236Houston systemsMyogenic vector system expresses DNA in myogenic tissue. Forgene replacement, vaccines, muscle atrophy therapy, etc.

Boehringer-Ingelheim Proteinase and EPO 541 058Ingelheim, Germany inhibitorsExpression of a mature proteinase, its partial purification,preparation of inhibitory active substrates.

Boehringer-Mannheim Recombinant core- WO 93/9144Mannheim, Germany streptavidinHost cells transformed with DNA encoding core-streptavidin;its expression and recovery from culture. Plasmid sequencesshown.

Ciba-Geigy AG Transforming growth EPO 542 679Basel, Switzerland factorsBioactive, dimeric hybrid TGF-b5, for wound, bone tissuehealing, cancer therapy, cardioprotection, anti-inflammatoryagent, etc.

Garvan Med. Res. Inst. Neuropeptide Y-Y1 WO 93/9227Darlinghurst, Australia receptorDNA sequences encoding human neuropeptide (NP) Y-Y1receptor; used to screen compounds for NP Y agonist andantagonist activity.

Genetics Institute Bone-shaping WO 93/9229Cambridge, Mass. proteinsProduction of recombinant, heterodimeric bone morphogeneticprotein, for treating bone defects, injury and wound healing.

Green Cross Corp. Mutant human EPO 541 952Osaka, Japan prourokinaseMutant prourokinase produced by amino-acid replacement,prolongs plasminogen activator's half-life in blood, improvesfibrin affinity.

Hoffmann-La Roche AG HLA class 1 EPO 540 997Basel, Switzerland DNA typingProbes to identify polymorphic sequences in amplified DNA, forrapid tissue-typing, individual identity, disease susceptibility.

Idemitsu Kosan Co. Ornithine decarboxylase EPO 542 287Tokyo antibodyHybridoma producing monoclonal antibody against ornithinedecarboxylase, for detecting cancer cells producing the humanenzyme.

Igen, Inc. Catalytic monoclonal WO 93/9247Rockville, Md. antibodyCatalytic monoclonal antibody, elicited by a ground stateantigen, able to cleave a polypeptide bound to a carriermolecule.

Immunogenetics Res. Fn. Ancestral gene WO 93/9249Subiaco, Australia analysisGenetic analysis of DNA sequences corresponding to ancestralhaplotypes of multigene complexes, such as human MHC.

Iowa, Univ. of Retrieving unknown WO 93/9246Iowa City, Iowa DNA sequenceGenerating PCR template permits highly specific amplificationof unknown DNA that flanks a known sequence region.

Joslin Diabetes Center Diabetes-associated WO 93/9141Boston antigenA 69kD protein, expressed in human islet cells, can detectautoantibodies, identify patients at risk of developing diabetesmellitus.

Jouveinal Research Inst. Rabbit gastric EPO 542 629Fresnes, France lipaseRecombinant rabbit gastric lipase; pharmaceutical compoundsto treat insufficiency or absence of this enzyme in humans.

Mass. General Hospital c-myc recombinant WO 93/8701Boston oncogenesA mammalian cell line that overexpresses Myc; purification ofc-Myc precursor; pharmaceuticals as c-Myc inhibitors.

Merck & Co. Toxin-antigen EPO 541 335Rahway, N.J. conjugatesDNA encodes hybrid protein comprising bacterial toxin andprotein exogenous to antigen-presenting cell; for immunekiller T cell response.

MIT (Mass. Inst. Tech.) Threonine WO 93/9225Cambridge, Mass. productionMutagenesis of gene encoding homoserine dehydrogenase, foroverproduction of threonine.

MIT (Mass. Inst. Tech.) Ubiquitin-specific WO 93/9235Cambridge, Mass. proteasesDNA encoding isolated ubiquitin-specific proteases, whichcleave at C-terminus of ubiquitin moiety in a fusion protein.

Mycogen Corp. Cockroach/bug WO 93/8692, 93San Diego controlling BtBacillus thuringiensis strain, and genes encoding its toxicproteins, which have activity against cockroaches in variousenvironments. Other Bt strains target coleopteran pests, e.g.,Colorado potato beetle.

NIH (Natl. Insts. Health) Lipolysis-mediating WO 93/9140Bethesda, Md. receptorCloned cells encode fat-cell-specific, lipolysis-mediating b-adrenergic receptor. To diagnose obesity caused by lowlipolysis.

Pittsburgh, Univ. of HLA molecular WO 93/9245Pittsburgh typingReverse dot-blot hybridization using tandem head-to-tailmonomers containing probes synthesized by staggeredcomplementary primers.

Plant Genetic Systems Modified insecticidal WO 93/9218Brussels, Belgium Bt genesDNA fragments encoding insecticidally-effective part ofBacillus thurinigiensis crystal protein; their expression inplant cells..

Research Corp. Tech. Vectors for erythroid WO 93/9239Tucson, Arizona gene therapyHybrid parvovirus vectors capable of site-specific integrationinto mammalian chromosome with minimal cytotoxicity.

Rohto Pharm. Co. Recombinant oxytocin EPO 542 424Osaka, Japan receptorBioactive, recombinant oxytocin receptor from human uterinemyometrium tissue; DNA sequence encoding same.

Rutgers University High-methionine WO 93/8682Piscataway, N.J. corn seedsCorn seed enriched by genetic engineering to provide poultryfeed containing more than 36% of methionine nutrititionalrequirements.

Salk Institute Kuniz protease WO 93/9233San Diego inhibitor (KPI)Recombinant KPI peptide, to regulate protease in amyloidosis,and treat coagulation disorders, enzyme-related head injuries.

Sandoz-Erfindungen Improved supersweet WO 93/9237Vienna, Austria cornSubunit corn-plant gene, controlled by heterologous promoter,yields supersweet kernels when harvested for food, starchyfor seed.

Sanwa Kagaku Kenkyusho Hepatitis C EPO 541 089Nagoya, Japan virus cDNAA cDNA encoding human hepatitis C virus gene, derived fromRNA template obtained from liver tissue or serum of diagnosedpatient.

Shionogi Seiyaku Kabushiki Brain natriuretic EPO 542 255Osaka, Japan peptide (BNP)Hybridoma for monoclonal antibody recognizing C-terminus ofhuman BNP, as index to diagnosis of, e.g., hypertension; heartand kidney states.

Stanford University Suppressor and WO 93/9234Stanford, Calif. progenitor cellsNatural suppressor cells secrete a protein suppressorfactor,.for immunotolerance to allogeneic transplants,immunosuppression.

Strohtech, Inc. Hemoglobin expression WO 93/8831Detroit in yeastDNA sequences encode a globin chain, or heme-bindingfragment, linked to a yeast promoter, for blood expanders,oxygen carriers.

Synergen, Inc. Interleukin-1 EPO 541 920Boulder, Colo. inhibitorsA recombinant, physiologically functional IL-1 inhibitor,active against IL-1 alpha and/or IL-1 beta; DNA sequencesencoding same.

Tepnel Medical Ltd. Testing anti-microbial WO 93/9248Manchester, U.K. resistanceTo test animal fluids, e.g., blood, milk, for antimicrobialagents, measure growth of resistant indicator organism addedto sample.

Texas, University of Squamous-cell WO 93/9436Austin, Texas carcinoma diagnosisA protein encoded by a rabbit cDNA is a molecular marker ofsquamous cell differentiation. Human counterpart inpreprorelaxin.

Texas, University of AIDS-specific WO 93/9230Austin, Texas proteinA 185kD protein isolated from HeLa cell extract regulates HIVgene expression; for AIDS immunodiagnosis, therapy,epidemiology.

Thera Gene HB Targeted viral WO 93/9221Kullavik, Sweden vectorA virus with inactivated cell-binding receptor complexed to anantibody aimed at an antigen on target cell surface mediatesviral entry.

Ticehurst, John R.,et al. Hepatitis A viral WO 93/9139Kensington, Md. sequencesHepatitis A virus (HAV) cDNA, cloned in bacterial plasmids, toassay presence of virus, produce antibodies, antigen.

Transkaryotic Therapies Vertebrate cell WO 93/9222Cambridge, Mass. transfectionMammalian somatic cells transfected with exogenous DNA byhomologous recombination encode desired therapeuticproducts.

Upjohn Co. Feline leukemia WO 93/9238Kalamazoo, Mich. vaccinesVaccines based on proteins expressed from recombinantbaculovirus, transformed with three gene sequences of felineleukemia virus.

Wellcome Foundation Baculovirus transfer EPO 542 466London vectors"A novel insect cell expression system." Amino-acid sequencesprovided.

Whitehead Biomed. Res. Inst. TGF-b receptor WO 93/9228Cambridge, Mass.DNA encoding transforming growth factor-b, types III and II.receptors of mammalian origin. Uses therefor.

(c) 1997 American Health Consultants. All rights reserved.