Published July 6 & 13 (EPO); July 7 (WO); July 6 (GB)

Akzo Nobel Hepatitis C WO 94/14974 Arnhem, Netherlands detection Monoclonal and anti-idiotypic antibodies against hepatitis C virus; immunodiagnostic reagent for its detection. Applied Res. Systems Urine protein WO 94/14959 Curaao, Neth. Antilles therapeutic Urine protein with anti-inflammatory, anti-coagulant, and anti-tumor activity that inhibits TGF-a binding. Arch Development Synthetic HSV WO 94/14971 Chicago promoters Synthetic herpes simplex virus (HSV) promoters with attached heterologous protein coding sequences; for vaccines. British Bio-Tech Antigenic protein WO 94/14969 Oxford, UK particles Proteinaceous particles containing particle-forming sequence related to yeast transposon protein and antigenic sequence. California, Univ. of Cell adhesion WO 94/14847, 848 Oakland, Calif. antibodies Antibodies to cell adhesion molecule peptide repeats; for inhibition of intercellular adhesion reactions. Doheny Eye Inst. Protocadherins WO 94/14960 Los Angeles Protocadherin coding sequences, recombinant production, and antibodies for modulating biological activity. Gist-Brocades Recombinant WO 94/14965, 966 Delft, Netherlands xylanase B Cloning and expression of fungal origin xylanase B and exo- polygalacturonases, vectors, and host cells. W. R. Grace E. coli-expressed EPO 605 073 New York protease Functional neutral protease genes from Vibrio or Bacillus, expression in gram-negative bacteria such as E. coli. INRA (Natl. Agron. Res. Modified CS31A WO 94/14967 Inst.) Paris protein capsule CS31A protein capsule subunit having an amino acid sequence modified by at least one heterologous peptide; for vaccines. Iowa State U. Virus/tumor WO 94/14956 Ames, Iowa killing Photoactivating chemical gene, such as luciferase, and photosensitizing chemical, for virus/tumor cell destruction. Japan Tobacco Transgenic plants EPO 604 662 Tokyo quickly Agrobacterium-mediated transformation of monocotyledon protoplasts with shortened time to regeneration of plant. Life Technologies ClaI Type-II EPO 605 854 Gaithersburg, Maryland restriction enzymes Recombinant hosts expressing ClaI Type-II restriction endonucleases, enzyme coding sequences, expression vectors. MIT(Mass. Inst. Tech.) Carcinogenesis EPO 605 789 Cambridge, Mass. screening Detection of protein encoded by an oncogene or mutant allele by immunoassay; for carcinogenesis screening.

MedImmune Streptococcus WO 94/14318 Gaithersburg, Maryland immunization Mycobacteria transformed with gene for antibody-eliciting Streptococcus surface protein; for animal immunization. Merck Frosst Canada Cyclooxygenase-2 WO 94/14977 Kirkland, Que. gene Cyclooxygenase-2 gene sequence and assay; for inhibition of enzyme activity. Novo Nordisk Plant cell wall WO 94/14952, 953 Bagsvaerd, Denmark degradation Polygalacturonase/endoglucanase activity enzymes, sequences; for plant cell wall degradation in wine/juice production. Novo Nordisk In vivo DNA WO 94/14968 Bagsvaerd, Denmark amplification Amplification of DNA sequence integrated into the genome by isolating, then selecting, cells with integrated DNA. Pasteur Inst. Glycopeptide WO 94/14961 Paris resistance Gene and protein sequences from Gram-positive bacteria; for protein conferring inducible resistance to glycopeptides. Purdue Univ. Aromatic WO 94/14955 W. Lafayette, Ind. intermediates Increased aromatic intermediate production by transforming cells with coding sequences for rate-limiting enzymes. Schering-Plough IL-4 receptor EPO 604 693, Kenilworth, N.J. antibodies WO 94/14975 Hybridomas and monoclonal antibodies to IL-4 receptor; for detection, production of IL-4-related disease therapeutics. Scripps Res. Inst. Multi-specific WO 94/14954 La Jolla, Calif. aldolase Broad substrate specificity aldolase isolated from Aureo- bacterium; condensation reactions with pyruvate disclosed. Selmer Sande Parathyroid EPO 604 706 Oslo, Norway plasmids Plasmids containing parathyroid hormone (PTH) sequences; for insertion into E. coli and yeasts. SmithKline Beecham Varicella-Zoster WO 94/14962 Rixensart, Belgium vaccine DNA and protein sequences for Varicella-Zoster virus (VZV) intermediate early protein; for vaccination against VZV. Solvay Stabilized EPO 605 040 Brussels, Belgium pullulinase Thermo- and acid-stable pullulinase that hydrolyzes amylopectin glucosidic bonds; DNA sequences, expression vectors. [In French] Stichting Scheikundig Modified fructan WO 94/14970 Onderzoek pattern The Hague, Neth. Transgenic plants with inserted fructosyltransferase gene, modifies fructan pattern; to improve plant nutritional value. Stiefel Labs Oligo- GB 2 272 932 Coral Gables, Fla. stabilization Degradation resistant oligonucleotides formed by inclusion of 3' hairpin loop structure; for therapeutic stabilization.

Strack, Hans et al. Proteins for PCR WO 94/14978 Salzburg, Austria Improved yield from PCR reactions by adding single-stranded DNA- binding proteins from thermophilic organisms. Sydney, Univ. of Recombinant WO 94/14958 Sydney, Australia tropoelastins Recombinant tropoelastins produced from polynucleotides, crosslinked elastins made from tropoelastin and variants. Synaptic Pharmaceuticals 5-HT serotonin WO 94/14957 Paramus, N.J. receptor 5-HT serotonin receptor DNA sequence, protein sequence, antibodies; for treating receptor-associated defects. Takara Shuzo Thermostable a- EPO 606 008 Kyoto, Japan galactosidase Coding sequence for thermostable a-galactosidase, process for producing the recombinant enzyme. Unilever Loop sequence GB 2 273 931 London truncation Functionally altered truncated polypeptide with replacement sequence from loop region; methods for production. Unilever Cutinase WO 94/14963, 964 London variants Cutinase variants with improved lipolytic activity or reduced anionic surfactant binding, gene sequences, hosts.

(c) 1997 American Health Consultants. All rights reserved.