Published Aug. 2 & 9 (EPO & GB); July 27 & Aug. 3(WO)
Abbott LabsHCV envelope WO 95/20664
Abbott Park, Ill.proteins
Expression vectors that produce hepatitis C virus (HCV)envelope proteins; for diagnosis and treatment.
AjinomotoOyster WO 95/20662
Tokyotransglutaminase
Coding sequence for Japanese oyster transglutaminase,encoded protein; for use as a salt-activated food gellingagent.
American CyanamidOpioid receptor-WO95/19986
Wayne, N.J.related proteins
Coding sequences of opioid receptor-related proteins,encoded proteins, antibodies to the proteins.
AmocoFlu sequence WO 95/20055
Chicagodetection
Nucleic acid probes that recognize flu RNA and DNAsequences; for detection and diagnosis.
Athena NeurosciencesLeukocyte WO 95/19790
S. San Franciscoadhesion antibody
Humanized antibodies against leukocyte adhesionmolecule (VLA-4); for treating multiple sclerosis.
Becton DickinsonTuberculosis WO 95/19781
Franklin Lakes, N.J.antibodies
Monoclonal and monospecific polyclonal antibodies thatbind Mycobacterium tuberculosis; for diagnosticimmunoassay.
BiocemPlant aconitase WO 95/20046
Aubiere, Francegene
Coding sequence of plant aconitase, encoded protein,gene fragments and chimeras.
BionebraskaMercury binding WO 95/20607
Lincoln, Neb.polypeptides
Metal binding polypeptides that have an antibody variableregion that reacts with mercury; for bioremediation.
Boston Univ.Self-assembling WO 95/20320
Bostonnucleic acids
Self-assembling nucleic acid constructs with attachedfunctional groups; for tagging or targeting.
Boston Univ.Protein antibody WO 95/20401
Bostonlibraries
Protein libraries of polyclonal antibodies and their codingsequences; for making disease- or patient-specific panels.
BresatecTransplantation WO 95/20661
Adelaide, Australiaantigen elimination
Elimination of tissue epitopes that cause transplantrejection by eliminating sugar residues andxenoantibodies.
British BiotechThrombin-activated GB 2 286190
Oxford, U.K.plasminogen
Plasminogen analogue that is activatable by thrombin tohave plasmin activity.
California, Univ. ofTumor cell matrixWO95/20041
Oakland, Calif.
Immortalized parotid tumor myoepithelial cells producingbasement membrane and extracellular matrix materials.
California, Univ. ofUniversal WO 95/20317
Oakland, Calif. donor cells
Oligos that bind to transplantation antigen genes; formaking universal donor cells.
California, Univ. ofSequence WO 95/20682
Oakland, Calif.artifact elimination
Elimination of stops/pauses in chain termination DNAsequencing by using nitrogen-containing organiccompounds.
CarlsbergCustomized protease WO 95/20039
Copenhagen, Denmarktransacylation
Mutant proteases that are customized to performpreselected transacylation reactions that result in specificproducts.
CheilPseudomonas GB 2 285 925
Seoul, S. Koreavaccine
Attenuated Pseudomonas aeruginosa strains; forproducing vaccines using cell wall proteins.
Cold Spr. Harbor LabscAMP/ras-related EPO666 314
Cold Spr. Harbor, N.Y.proteins
Cloned genes coding for proteins involved in cAMP- orras-related pathways; for insertion into microorganisms.
Columbia Univ.Vacuolar WO 95/20043
New YorkATPase oligos
Oligonucleotides that bind to the vacuolar ATPase gene;for inhibiting enzyme activity and reducing acidsecretion.
Duke Univ.Protein WO 95/20651
Durham, N.C.prenyltransferase
Coding sequence of a protein prenyltransferase, encodedprotein; for modifying proteins.
Goldsmith SeedsFungus WO 95/19698
Gilroy, Calif.resistant seeds
Catharanthus and other crop seeds that are resistant tofungal infection; for disease control.
Groningen St. Univ.Thermostable WO 95/20663
Groningen, Netherlandsneutral proteases
Coding sequences of thermostable Bacillus neutralproteases, encoded protein, expression vectors containinggene.
Gx BiosystemsRecombined WO 95/20657
Holte, Denmarkbacterial adhesins
Selected or recombined bacterial adhesins, bacteriaexpressing these adhesins; for specific binding.
HoechstHSV-1 antisense EPO 666 317
Frankfurt, Germanyoligos
Antisense oligonucleotides against Herpes simplex virus(HSV)-1 and their preparation [in German].
Human Genome SciencesHematopoietic WO95/19985
Rockville, Md.maturation factor
Coding sequence of hematopoietic maturation factor,encoded protein, antibodies to the protein.
Human Genome SciencesGrowth hormone WO95/20398
Rockville, Md.variants
Coding sequences of human growth hormone variants,derivatives, and analogues; for disease treatment.
Human Genome SciencesDNA repair WO95/20678
Rockville, Md.proteins
Coding sequences of DNA mismatch repair proteinsmapped to chromosomes 2, 3, and 7; for diagnosis andtreatment.
HybridonSequencing WO 95/20680
Worcester, Mass.short oligos
Method for determining the nucleotide sequence of shortoligonucleotides by using gel separation mobilities.
Incyte PharmaDifferential WO 95/20681
Palo Alto, Calif.expression assay
Method for quantifying relative abundance of genetranscripts; for measuring differential expression.
Iowa St. Univ.Teleomerase EPO 666 313
Ames, IowaRNA
Cloning of the RNA component of teleomerase; foridentifying and competing with tumor cell teleomeraseRNA.
INRA (Inst. Natl. Rec. Agron.)Transgenic WO95/20653
Parisembryo reporting
Coding sequence of Vargula luciferase; for detection oftransgenic embryos.
Japanese Agri. MinistryProtoplast EPO 665290
Ibaraki, Japangene transfer
Plant gene transfer method using protoplasts andpolycation assistance; for making transgenic plants.
Julich Res. Ctr.Gram-negative WO95/20048
Julich, Germanyproteins
Vectors for secretion of gram-negative bacteria outermembrane proteins from gram-positive bacteria; forproduction.
LynxvaleResistance WO 95/20044
Cambridge, U.K.macrophage protein
Macrophage protein having N-terminal src homology thatcontrols natural resistance to microorganisms.
Mass., Univ. Med. Ctr.Immunization WO95/20660
Worcester, Mass.with DNA
Injection of a DNA transcription unit encoding anantigen; for immunization.
Medeva HoldingsAttenuated WO 95/20665
Amsterdam, NetherlandshtrA bacteria
Attenuated bacterial strains containing vectors with thehtrA promoter; for vaccines.
MRC (Med. Res. Counc.)HSV non-infectious WO95/20049
Londonparticles
Virion-free, non-infectious viral particles containingHerpes simplex virus (HSV)-1 or 2.
MedigeneRegulatory WO 95/20652
Martinsreid, Germanyfactor activity
Regulatory factor activity determined by the interaction oftwo regulatory regions on a reporter enzyme gene.
Minnesota, Univ. ofAlzheimer's WO 95/20666
Minneapolistransgenic model
Transgenic animals whose cells contain the amyloidprecursor protein gene sequence; for studyingAlzheimer's disease.
Mor Res. ApplicationsLymphoblastoid WO95/20605
Givat Shrauel, Israelantibody
Immunostimulatory antibody that binds to Blymphoblastoid cells; for lymphocyte growth and tumortreatment.
NIH (Natl. Inst. Hlth.)Human mu WO 95/20667
Bethesda, Md.opiate receptor
Coding sequence of human mu opiate receptor localizedto chromosome 6, encoded protein.
New York, St. Univ. ofAffinity WO95/20677
Buffalo, N.Y.DNA capture
Affinity-based method of capturing genes of interest byusing immobilized hapten-linked oligo probes.
New York Univ.Phosphacan WO 95/20397
New Yorkproteoglycan
Coding sequence of phosphacan proteoglycan, encodedprotein; for promoting nerve regeneration.
Nickerson BiochemModified plants WO95/20668
Cambridge, U.K.from transgenics
Modified plants produced by crossing two lines, one ofwhich is transgenic.
N. Carolina St. Univ.Woody WO 95/19697
Raleigh, N.C.perennial selection
Genetic markers for heritable traits in woody perennials;for selecting and propagating plants.
N. Carolina, Univ. ofPeptide WO 95/20601
Chapel Hill, N.C.library fusions
Fusion binding proteins called totally synthetic affinityreagents made from peptide libraries.
Pioneer Hi-BredNematode-resistant WO95/20669
Des Moines, Iowasoybean
Introduction of soybean cyst nematode resistance genesinto germplasm; for breeding and identifying resistantplants.
PPL TherapeuticsIn situ WO 95/20042
Roslin, U.K.ES cells
Embryonic stem (ES) cells isolated in situ from embryoscontaining both ES and differentiated cells.
Proteine PerformanceBaculovirus WO 95/20672
St.-Christol-les-Ales, Franceimmunoglobulin expression
Baculovirus-based vector; for expression ofimmunoglobulins in insect cells.
Queensland, Univ. ofPapilloma WO 95/20659
Parkville, Australiavirus-like particles
Modified papilloma virus L2 protein that binds minimalamounts of DNA; for making virus-like particles.
Renner et al.Protein-free EPO 666 312
Muntelier, Switzerlandgrowth
Cell lines that readily grow in serum- and protein-freemedium; for recombinant protein production.
Res. Corp. Technol.Metastatic WO 95/20656
Tucson, Ariz.cancer gene
Coding sequence of the mts-1 gene, encoded protein,antibodies to the protein; for detecting metastatic cancer.
Res. Develop. Fdn.Mosquito WO 95/19990
Carson City, Nev.antiviral protein
Protein from Aedes albopictus cells that is associatedwith lysosomal membranes and induces an antiviral state.
Rhone-Poulenc RorerAAV vector WO 95/20671
Antony, Francepreparation
Adeno-associated viral (AAV) vector preparation, cellsand vectors used for preparation; for gene therapy.
Royal Sluis FranceDefective WO 95/19696
Nimes, Franceendosperm
Male gametophyte genetic factor causing defectiveendosperm and lack of germination; for producing hybridseeds.
Royal Cancer Hosp.EGF WO 95/20045
Londonreceptor antibodies
Antibodies against epidermal growth factor (EGF)receptor that have antitumor activity; for use in cancertherapy.
Royal Cancer Hosp.Polypeptide WO 95/20654
Londonfolding complex
Coding sequence of polypeptide folding complex,encoded protein, antibodies to the protein.
Salk Inst. Biotech. Indus. Assoc.NMDA GB 2286 188
La Jolla, Calif.receptor subunits
Coding sequence of N-methyl-D-aspartate (NMDA)receptor subunits, encoded protein; for identifyingantagonists.
Salk Inst.Protein WO 95/19993
La Jolla, Calif.kinase mutants
Coding sequences of protein kinase mutants; forscreening DNA double-strand break repair activity.
ScheringNK antigen WO 95/20604
Kenilworth, N.J.antibodies
Antibodies specific for natural killer (NK) cell surfaceantigen, coding sequences for genes.
ScotgenRecombinant GB 2 286 189
Aberdeen, U.K.binding proteins
Specific binding proteins containing fragments from morethan one antibody; for bispecific binding.
Scripps Res. Inst.TGF-a WO 95/19987
La Jolla, Calif.assay
Specific, non-radioactive method for detectingtransforming growth factor (TGF)-a using a luciferasereporter gene.
Scripps Res. Inst.Coagulation-related WO95/20655
La Jolla, Calif.receptors
Coding sequence of cellular receptors homologous tocoagulation factors V and VIII, encoded proteins.
ShiseidoC-terminal EPO 666 318
Tokyoamidation enzyme
Enzyme participating in C-terminal amidation, codingsequence of enzyme, expression vector.
SolvayGlucose EPO 665 291
Brussels, Belgiumoxidase vector
Expression vector designed to code for glucose oxidase;for extracellular production of the enzyme [in French].
SudzuckerNon-caloric WO 95/20047
Mannheim, Germanysugars
Coding sequences of saccharose isomerases, encodedproteins; for production of non-caloric sugars.
Targeted GeneticsCD69 WO 95/20670
Seattleregulatory sequences
Transcriptional regulatory sequences from the CD69gene; for controlling cells expressing CD69.
TonenOrganic EPO 666 316
Tokyosolvent resistance
Pseudomonas strains subjected to mutagenesis forincreasing resistance to organic solvents.
Victoria Univ.Bacterial WO 95/20658
Manchester, U.K.infection proteins
Coding sequences of proteins expressed duringstreptococci or enterococci infection, encoded proteins;for therapy.
Yale Univ.Deltex proteinsWO 95/19779
New Haven, Conn.
Coding sequences of Drosophila and human deltex genes;for diagnosis and therapy.
_ Compiled By Chester A. Bisbee
(c) 1997 American Health Consultants. All rights reserved.