Published Aug. 2 & 9 (EPO & GB); July 27 & Aug. 3(WO)

Abbott LabsHCV envelope WO 95/20664

Abbott Park, Ill.proteins

Expression vectors that produce hepatitis C virus (HCV)envelope proteins; for diagnosis and treatment.

AjinomotoOyster WO 95/20662

Tokyotransglutaminase

Coding sequence for Japanese oyster transglutaminase,encoded protein; for use as a salt-activated food gellingagent.

American CyanamidOpioid receptor-WO95/19986

Wayne, N.J.related proteins

Coding sequences of opioid receptor-related proteins,encoded proteins, antibodies to the proteins.

AmocoFlu sequence WO 95/20055

Chicagodetection

Nucleic acid probes that recognize flu RNA and DNAsequences; for detection and diagnosis.

Athena NeurosciencesLeukocyte WO 95/19790

S. San Franciscoadhesion antibody

Humanized antibodies against leukocyte adhesionmolecule (VLA-4); for treating multiple sclerosis.

Becton DickinsonTuberculosis WO 95/19781

Franklin Lakes, N.J.antibodies

Monoclonal and monospecific polyclonal antibodies thatbind Mycobacterium tuberculosis; for diagnosticimmunoassay.

BiocemPlant aconitase WO 95/20046

Aubiere, Francegene

Coding sequence of plant aconitase, encoded protein,gene fragments and chimeras.

BionebraskaMercury binding WO 95/20607

Lincoln, Neb.polypeptides

Metal binding polypeptides that have an antibody variableregion that reacts with mercury; for bioremediation.

Boston Univ.Self-assembling WO 95/20320

Bostonnucleic acids

Self-assembling nucleic acid constructs with attachedfunctional groups; for tagging or targeting.

Boston Univ.Protein antibody WO 95/20401

Bostonlibraries

Protein libraries of polyclonal antibodies and their codingsequences; for making disease- or patient-specific panels.

BresatecTransplantation WO 95/20661

Adelaide, Australiaantigen elimination

Elimination of tissue epitopes that cause transplantrejection by eliminating sugar residues andxenoantibodies.

British BiotechThrombin-activated GB 2 286190

Oxford, U.K.plasminogen

Plasminogen analogue that is activatable by thrombin tohave plasmin activity.

California, Univ. ofTumor cell matrixWO95/20041

Oakland, Calif.

Immortalized parotid tumor myoepithelial cells producingbasement membrane and extracellular matrix materials.

California, Univ. ofUniversal WO 95/20317

Oakland, Calif. donor cells

Oligos that bind to transplantation antigen genes; formaking universal donor cells.

California, Univ. ofSequence WO 95/20682

Oakland, Calif.artifact elimination

Elimination of stops/pauses in chain termination DNAsequencing by using nitrogen-containing organiccompounds.

CarlsbergCustomized protease WO 95/20039

Copenhagen, Denmarktransacylation

Mutant proteases that are customized to performpreselected transacylation reactions that result in specificproducts.

CheilPseudomonas GB 2 285 925

Seoul, S. Koreavaccine

Attenuated Pseudomonas aeruginosa strains; forproducing vaccines using cell wall proteins.

Cold Spr. Harbor LabscAMP/ras-related EPO666 314

Cold Spr. Harbor, N.Y.proteins

Cloned genes coding for proteins involved in cAMP- orras-related pathways; for insertion into microorganisms.

Columbia Univ.Vacuolar WO 95/20043

New YorkATPase oligos

Oligonucleotides that bind to the vacuolar ATPase gene;for inhibiting enzyme activity and reducing acidsecretion.

Duke Univ.Protein WO 95/20651

Durham, N.C.prenyltransferase

Coding sequence of a protein prenyltransferase, encodedprotein; for modifying proteins.

Goldsmith SeedsFungus WO 95/19698

Gilroy, Calif.resistant seeds

Catharanthus and other crop seeds that are resistant tofungal infection; for disease control.

Groningen St. Univ.Thermostable WO 95/20663

Groningen, Netherlandsneutral proteases

Coding sequences of thermostable Bacillus neutralproteases, encoded protein, expression vectors containinggene.

Gx BiosystemsRecombined WO 95/20657

Holte, Denmarkbacterial adhesins

Selected or recombined bacterial adhesins, bacteriaexpressing these adhesins; for specific binding.

HoechstHSV-1 antisense EPO 666 317

Frankfurt, Germanyoligos

Antisense oligonucleotides against Herpes simplex virus(HSV)-1 and their preparation [in German].

Human Genome SciencesHematopoietic WO95/19985

Rockville, Md.maturation factor

Coding sequence of hematopoietic maturation factor,encoded protein, antibodies to the protein.

Human Genome SciencesGrowth hormone WO95/20398

Rockville, Md.variants

Coding sequences of human growth hormone variants,derivatives, and analogues; for disease treatment.

Human Genome SciencesDNA repair WO95/20678

Rockville, Md.proteins

Coding sequences of DNA mismatch repair proteinsmapped to chromosomes 2, 3, and 7; for diagnosis andtreatment.

HybridonSequencing WO 95/20680

Worcester, Mass.short oligos

Method for determining the nucleotide sequence of shortoligonucleotides by using gel separation mobilities.

Incyte PharmaDifferential WO 95/20681

Palo Alto, Calif.expression assay

Method for quantifying relative abundance of genetranscripts; for measuring differential expression.

Iowa St. Univ.Teleomerase EPO 666 313

Ames, IowaRNA

Cloning of the RNA component of teleomerase; foridentifying and competing with tumor cell teleomeraseRNA.

INRA (Inst. Natl. Rec. Agron.)Transgenic WO95/20653

Parisembryo reporting

Coding sequence of Vargula luciferase; for detection oftransgenic embryos.

Japanese Agri. MinistryProtoplast EPO 665290

Ibaraki, Japangene transfer

Plant gene transfer method using protoplasts andpolycation assistance; for making transgenic plants.

Julich Res. Ctr.Gram-negative WO95/20048

Julich, Germanyproteins

Vectors for secretion of gram-negative bacteria outermembrane proteins from gram-positive bacteria; forproduction.

LynxvaleResistance WO 95/20044

Cambridge, U.K.macrophage protein

Macrophage protein having N-terminal src homology thatcontrols natural resistance to microorganisms.

Mass., Univ. Med. Ctr.Immunization WO95/20660

Worcester, Mass.with DNA

Injection of a DNA transcription unit encoding anantigen; for immunization.

Medeva HoldingsAttenuated WO 95/20665

Amsterdam, NetherlandshtrA bacteria

Attenuated bacterial strains containing vectors with thehtrA promoter; for vaccines.

MRC (Med. Res. Counc.)HSV non-infectious WO95/20049

Londonparticles

Virion-free, non-infectious viral particles containingHerpes simplex virus (HSV)-1 or 2.

MedigeneRegulatory WO 95/20652

Martinsreid, Germanyfactor activity

Regulatory factor activity determined by the interaction oftwo regulatory regions on a reporter enzyme gene.

Minnesota, Univ. ofAlzheimer's WO 95/20666

Minneapolistransgenic model

Transgenic animals whose cells contain the amyloidprecursor protein gene sequence; for studyingAlzheimer's disease.

Mor Res. ApplicationsLymphoblastoid WO95/20605

Givat Shrauel, Israelantibody

Immunostimulatory antibody that binds to Blymphoblastoid cells; for lymphocyte growth and tumortreatment.

NIH (Natl. Inst. Hlth.)Human mu WO 95/20667

Bethesda, Md.opiate receptor

Coding sequence of human mu opiate receptor localizedto chromosome 6, encoded protein.

New York, St. Univ. ofAffinity WO95/20677

Buffalo, N.Y.DNA capture

Affinity-based method of capturing genes of interest byusing immobilized hapten-linked oligo probes.

New York Univ.Phosphacan WO 95/20397

New Yorkproteoglycan

Coding sequence of phosphacan proteoglycan, encodedprotein; for promoting nerve regeneration.

Nickerson BiochemModified plants WO95/20668

Cambridge, U.K.from transgenics

Modified plants produced by crossing two lines, one ofwhich is transgenic.

N. Carolina St. Univ.Woody WO 95/19697

Raleigh, N.C.perennial selection

Genetic markers for heritable traits in woody perennials;for selecting and propagating plants.

N. Carolina, Univ. ofPeptide WO 95/20601

Chapel Hill, N.C.library fusions

Fusion binding proteins called totally synthetic affinityreagents made from peptide libraries.

Pioneer Hi-BredNematode-resistant WO95/20669

Des Moines, Iowasoybean

Introduction of soybean cyst nematode resistance genesinto germplasm; for breeding and identifying resistantplants.

PPL TherapeuticsIn situ WO 95/20042

Roslin, U.K.ES cells

Embryonic stem (ES) cells isolated in situ from embryoscontaining both ES and differentiated cells.

Proteine PerformanceBaculovirus WO 95/20672

St.-Christol-les-Ales, Franceimmunoglobulin expression

Baculovirus-based vector; for expression ofimmunoglobulins in insect cells.

Queensland, Univ. ofPapilloma WO 95/20659

Parkville, Australiavirus-like particles

Modified papilloma virus L2 protein that binds minimalamounts of DNA; for making virus-like particles.

Renner et al.Protein-free EPO 666 312

Muntelier, Switzerlandgrowth

Cell lines that readily grow in serum- and protein-freemedium; for recombinant protein production.

Res. Corp. Technol.Metastatic WO 95/20656

Tucson, Ariz.cancer gene

Coding sequence of the mts-1 gene, encoded protein,antibodies to the protein; for detecting metastatic cancer.

Res. Develop. Fdn.Mosquito WO 95/19990

Carson City, Nev.antiviral protein

Protein from Aedes albopictus cells that is associatedwith lysosomal membranes and induces an antiviral state.

Rhone-Poulenc RorerAAV vector WO 95/20671

Antony, Francepreparation

Adeno-associated viral (AAV) vector preparation, cellsand vectors used for preparation; for gene therapy.

Royal Sluis FranceDefective WO 95/19696

Nimes, Franceendosperm

Male gametophyte genetic factor causing defectiveendosperm and lack of germination; for producing hybridseeds.

Royal Cancer Hosp.EGF WO 95/20045

Londonreceptor antibodies

Antibodies against epidermal growth factor (EGF)receptor that have antitumor activity; for use in cancertherapy.

Royal Cancer Hosp.Polypeptide WO 95/20654

Londonfolding complex

Coding sequence of polypeptide folding complex,encoded protein, antibodies to the protein.

Salk Inst. Biotech. Indus. Assoc.NMDA GB 2286 188

La Jolla, Calif.receptor subunits

Coding sequence of N-methyl-D-aspartate (NMDA)receptor subunits, encoded protein; for identifyingantagonists.

Salk Inst.Protein WO 95/19993

La Jolla, Calif.kinase mutants

Coding sequences of protein kinase mutants; forscreening DNA double-strand break repair activity.

ScheringNK antigen WO 95/20604

Kenilworth, N.J.antibodies

Antibodies specific for natural killer (NK) cell surfaceantigen, coding sequences for genes.

ScotgenRecombinant GB 2 286 189

Aberdeen, U.K.binding proteins

Specific binding proteins containing fragments from morethan one antibody; for bispecific binding.

Scripps Res. Inst.TGF-a WO 95/19987

La Jolla, Calif.assay

Specific, non-radioactive method for detectingtransforming growth factor (TGF)-a using a luciferasereporter gene.

Scripps Res. Inst.Coagulation-related WO95/20655

La Jolla, Calif.receptors

Coding sequence of cellular receptors homologous tocoagulation factors V and VIII, encoded proteins.

ShiseidoC-terminal EPO 666 318

Tokyoamidation enzyme

Enzyme participating in C-terminal amidation, codingsequence of enzyme, expression vector.

SolvayGlucose EPO 665 291

Brussels, Belgiumoxidase vector

Expression vector designed to code for glucose oxidase;for extracellular production of the enzyme [in French].

SudzuckerNon-caloric WO 95/20047

Mannheim, Germanysugars

Coding sequences of saccharose isomerases, encodedproteins; for production of non-caloric sugars.

Targeted GeneticsCD69 WO 95/20670

Seattleregulatory sequences

Transcriptional regulatory sequences from the CD69gene; for controlling cells expressing CD69.

TonenOrganic EPO 666 316

Tokyosolvent resistance

Pseudomonas strains subjected to mutagenesis forincreasing resistance to organic solvents.

Victoria Univ.Bacterial WO 95/20658

Manchester, U.K.infection proteins

Coding sequences of proteins expressed duringstreptococci or enterococci infection, encoded proteins;for therapy.

Yale Univ.Deltex proteinsWO 95/19779

New Haven, Conn.

Coding sequences of Drosophila and human deltex genes;for diagnosis and therapy.

_ Compiled By Chester A. Bisbee

(c) 1997 American Health Consultants. All rights reserved.