Published Nov. 8 & 15 (EPO); Nov. 2 & 9 (WO); Nov. 8& 15 (GB)
Amano PharmaAscorbate oxidaseEPO 682116
Aichi, Japan
Gene for ascorbate oxidase, encoded protein; forexpression in and production from microorganisms.
Appl. Tech. GeneticsResolvase mutation WO95/29251
Malvern, Penn.detection
Detection of mutations in isolated double-stranded DNAusing resolvases.
AvironMutant VZVWO 95/29991
Burlingame, Calif.
Mutant Varicella Zoster virus (VZV) and genes; formaking immunogenic compositions and developingassays.
Biotech. Biol. Res. Counc.Engineered WO95/30000
Swindon, U.K.FactorIX genes
Factor IX genes engineered to reduce aberrant splicingsites; for increased yields and improved gene therapy.
Boehringer IngelheimB cell WO 95/29935
Ridgefield, Conn.development
Growth of B cells and differentiation of them intoantibody-producing cells.
Bristol-Myers SquibbCTLA4 receptorEPO 682039
New York
Gene for CTLA4 receptor, encoded protein, fusions, andsoluble forms; for regulating T cell interactions.
British Tech. Grp.Gamma-WO 95/29235
Londonlatroinsectotoxin
Gene for truncated, active version of invertebrate-specificgamma-latroinsectotoxin from black widow spiders.
Cadus PharmaAdenylyl cyclasesWO 95/30012
Tarrytown, N.Y.
Mammalian adenylyl cyclases functionally expressed inyeast cells; for screening assays.
Calif. Inst. Tech.Ubiquitin fusion WO95/29195
Pasadena, Calif.assay
Ubiquitin fusion proteins in which the two ends are fusedto proteins to be tested for their ability to interact.
CNRS (Ctr. Natl. Rec. Sci.)Leishmania WO95/30006
Parisvaccine
Gene for a Leishmania major protein, encoded protein;for preparing vaccines.
Children's Hosp.AngiostatinWO 95/29242
Boston
Endothelial cell growth inhibitor protein calledangiostatin that is similar to a murine plasminogenfragment.
ChironPDGF A-chain genesEPO 682 110
Emeryville, Calif.
Genes for two forms of PDGF A-chain, expressionvectors; for producing homodimers and heterodimers.
ChironImproved ribozyme WO 95/29241
Emeryville, Calif.catalysis
Ribozymes with catalytic, substrate binding, anddisplaceable antisense arms; for improved catalyticturnover rates.
Ciba-GeigyFungal PCR assayWO 95/29260
Basel, Switzerland
DNA sequences from internal transcribed spacer ofribosomal RNA genes; for PCR-identification of fungalpathogens.
Ciba-GeigyCell-cell targetingWO 95/30014
Basel, Switzerland
Bifunctional protein that allows its producing cell totarget specific cells; for cancer therapy.
Cold Spr. Harbor LabsProtein tyrosine WO95/30008
Cold Spring Harbor, N.Y.phosphatases
Genes for Type III density-enhanced protein tyrosinephosphatases, encoded protein, production methods.
CSIRO (Comm. Sci.Mildew resistant WO95/29238
Ind. Res. Org.)crops
Campbell, Australia
Genes for resistance against rust and mildew; for creatingtransgenic plants and crops.
CordixaLeishmania immune WO 95/29239
Seattleresponse
Leishmania homolog of eukaryotic initiation factor 4A;for evaluating Th1 immune response and IL-12production.
Creative BiomoleculesMorphogen protein-WO95/30003
Hopkinton, Mass.specific receptors
Genes for morphogen protein-specific receptors, encodedprotein, production methods; for diagnosis.
Cyanamid IbericaPRRS virus vaccineGB 2 289279
Madrid, Spain
Porcine reproductive and respiratory syndrome (PRRS)virus proteins from baculoviruses; for vaccines.
Dade Intl.Fusions to penIWO 95/30016
Deerfield, Ill.
Synthesis, isolation, and purification of peptides usingfusions to penI protein.
Dana-Farber Cancer Inst.Lymphocyte WO95/29236
Bostonactivation antigens
Genes for HB15-related lymphocyte activation antigens,encoded proteins, antibodies to them.
DeKalb GeneticsMaize water WO 95/30005
DeKalb, Ill.genes
Identification and characterization of genes involved inthe response of maize plants to water.
EniricercheStable bacterial EPO 681 027
Milan, Italyplasmid
Plasmid vector with high stability and efficientexpression; for use in Escherichia coli and Bacillussubtilis.
FatroPig pseudorabies EPO 682 108
Bologna, Italyvaccine
Pig pseudorabies viral strains used to prepare a wide-spectrum vaccine.
Florida, Univ. ofImplants for WO 95/29988
Gainesville, Fla.diabetes
Growth of functional Islets of Langerhans in vitro; fororgan replacement and diabetes therapy.
Freeman, S.Disease-targeted WO 95/29704
New Orleanscells
Cell compositions with properties allowing migration tospecific tissues when injected; for disease treatment.
Gatsby Charitable Fdn.Saponin glycosyl WO95/30009
Londonhydrolases
Proteins with saponin glycosyl hydrolase activity, genesfor these proteins, antibodies against them.
Gene ShearsIn vivo expressionWO 95/29254
Neutral Bay, Australiascreen
In vivo gene expression system for screening formodulation of target gene sequence activity.
GenentechCardiotrophinWO 95/29237
S. San Francisco
Gene encoding cardiotrophin, encoded protein; fortreatment of heart failure and other cardiac disease.
Genetics Inst.P-selectin ligand WO 95/30001
Cambridge, Mass.glycoprotein
Gene for P-selectin ligand glycoprotein, encoded protein,production methods; for treating inflammatory disease.
GentaPapillomavirus WO 95/28942
San Diegooligos
Antisense oligos targeted to human papillomavirus genes;for infection treatment.
Hong Kong Univ. Sci. Tech.CellobiaseGB 2289 050
Hong Kong
Gene for cellobiase, encoded protein, yeast and bacterialhost strains; for converting cellobiose to glucose.
ImmunexInhibitory viral WO 95/30015
Seattleproteins
Viral proteins that bind to Class II MHC antigens; forinhibiting antigen-specific response and EBV infection.
ImmunoPoxvirus vector WO 95/30018
Vienna, Austriavaccines
Defective poxviruses containing heterologous genes; forprotein production and vaccination.
Isis PharmaCytomegalovirus WO 95/28941
Carlsbad, Calif.oligos
Antisense oligo targeted to cytomegalovirus geneproducts; for infection treatment.
Japan TobaccoPlant carbonic EPO 682 117
Tokyoanhydrase
Gene coding for carbonic anhydrase from monocotyledonplants.
Japan Res. Develop. Corp.Primary liver cellsEPO682 106
Saltama, Japan
Identification and long-term growth of liver parenchymalcells; for studying liver disease mechanisms.
Japan Res. Develop. Corp.Dermal papilla EPO682 107
Saltama, Japancells
Long-term culture of dermal papilla cells using epidermalcell co-culture and conditioned medium.
La Jolla Cancer Res. Fdn.EpitaxinWO95/29695
La Jolla, Calif.
Epitaxin, a tumor cell motility and DNA synthesis factor,and antibodies to it; for cancer therapy.
Eli LillyPlatelet factor-4EPO 682 114
Indianapolis
Gene for platelet factor-4, encoded protein, its precursorand modified forms.
Lipps, B.a-TaipoxinWO 95/29987
Belaire, Tex.
a-taipoxin and its preparation; for cell growth promotionand wound treatment.
Ludwig Inst. Cancer Res.Fibroblast activation WO95/29233
New Yorkfactor
Identification and isolation of the gene encodingfibroblast activation protein.
Mayo Fdn.Remyelination WO 95/30004
Rochester, Minn.antibodies
Monoclonal IgM antibodies that promote central nervoussystem remyelination.
MerckTNF production GB 2 289 218
Rahway, N.J.inhibition
Inhibition of TNF production by an adenosine receptoragonist; for therapy of autoimmune diseases.
MerckCephamycin WO 95/29253
Rahway, N.J.production
Genes encoding enzymes involved in the later stages ofcephamycin biosynthesis; for antibiotic production.
Merck Sharp & DohmeGABAA receptorWO95/29234
Hoddesdon, U.K. gamma subunit
Gene for the gamma subunit of the GABAA receptor,host cells that can express the receptor; for therapeuticscreening.
Michigan St. Univ.Prostate WO 95/29990
E. Lansing, Mich.cancer cells& 29994
Immortalized and malignant prostatic cell linestransformed with various viruses; for study of prostatecancer.
Michigan, Univ. ofChromosomes in WO95/29992
Ann Arbor, Mich.muntjac cells
Introduction of chromosomes or fragments into a femalemuntjac cell line; for chromosome purification.
Michigan, Univ. ofAdenoviral WO 95/29993
Ann Arbor, Mich.vectors
Expression vectors containing heterologous genes that arebased on adenoviruses; for gene therapy.
Molec. Gen. Res. Assoc.DNA repair WO95/29245
Parisdeficiencies
BTF2 complex proteins, especially p34 and p44; fordiagnosing DNA repair process deficiencies.
Mt. Sinai Hosp.Neural receptor WO95/30326
Torontotyrosine kinase
Gene for neural receptor tyrosine kinase, encoded protein;for screening agonists.
Mycogen Plant Sci.Synthetic crystal EPO 682115
Wilmington, Del.protein genes
Synthetic genes for Bacillus thuringiensis crystal proteinusing preferred codons; for high expression in plants.
Nabel et al.Particle-mediated WO 95/29703
Ann Arbor, Mich.gene transfer
Introduction of an HIV-protective agent intohematopoietic cells using particle-mediated gene transfer.
NIH (Natl. Inst. Hlth.)Melanoma WO 95/29193
Bethesda, Md.antigens
Gene for melanoma antigen recognized by T cells,encoded protein, modified versions; for immunogenicvaccine.
NIH (Natl. Inst. Hlth.)T-cell WO 95/29240
Bethesda, Md.lymphotropic virus
Primate T-cell lymphotropic virus, encoded proteins,antibodies to them; for anti-viral agent screening.
NIH (Natl. Inst. Hlth.)Transplants for WO95/29989
Bethesda, Md.diabetes
Induction of growth and differentiation of fetal pancreaticcells; for making transplantable islets for diabetics.
Novo NordiskHeparin binding WO 95/28949
Bagsvaerd, Denmarkprotein
Gene for heparin binding protein, modifications, andfusions; for sepsis treatment.
Ono PharmaEndothelial cell EPO 682 113
Osaka, Japanprotein
Gene for a protein from an endothelial cell line, encodedprotein, antibodies; for vascular disease treatment.
Pasteur Inst.Transgenic EPO 682 111
Parisanimal screens
Transgenic animal models with inserted genes that can beused to screen pharmaceutical compounds [in French].
Pasteur Inst.Homologous EPO 682 112
Parisrecombination vector
Process for obtaining gene expression or improving it byusing a homologous recombination vector system [inFrench].
Pennsylvania, Univ. ofBiologically WO95/29690
Philadelphiaactive protein mimics
Recombinant antibody library to a biologically activeprotein, CDR sequence synthesis; for identifying mimics.
Pioneer Hi-BredMaize pollen WO 95/29247
Des Moines, Iowacontrol
Regulatory element that confers anther tapetal cell-specific expression; for controlling maize pollenproduction.
Princeton Univ.Bile acid DNA WO95/29186
Princeton, N.J.carrier
Transfection DNA carrier containing heterologous geneand a bile acid with an amine-containing side chain.
Proctor & GambleSubtilisin WO 95/30010 &30011
Cincinnativariants
Subtilisin variants and the genes encoding them; forcleaning a variety of surfaces.
Protein Design LabsHumanized EPO 682 040
Mountain View, Calif.antibody production
Humanized immunoglobulins with complementarydetermining regions and consensus sequence framework.
Rhone MerieuxDeleted herpes WO95/29248
Lyon, Francevectors
Herpes virus vectors with deleted genes; for encodingantigens and making vaccines.
San Diego Reg. Cancer Ctr.Sensitizing WO95/30002
San Diegotumors
Introduction of sensitizing gene activity into tumor cells;for enhanced cancer therapy.
Sapporo BreweriesADP ribosylationEPO 681028
Tokyo factor vector
Vector with ADP ribosylation factor promoter; fordifferential expression in plant seeds and leaves.
Singapore, Natl. Univ. ofMosquito toxinGB 2289 049
Singapore
Protease-deficient bacterial strain containing a geneencoding a protein that is a mosquito toxin.
Singapore, Natl. Univ. ofDNA repair assayGB 2289 125
Singapore
Assay for human DNA repair enzyme O6-methylguanine-DNA methyltransferase (MGMT) using V8 protease.
Sloan-Kettering Inst.Fc receptor WO 95/28959
New Yorktransgenics
Transgenic animals with human Fc receptor domainreplaces the endogenous one; for treating autoimmunity.
Smith & NephewSynthetic growth EPO 681846
Londonsubstrate
Anchorage-dependent mammalian cells grown on ahydrophobic, non-growth inhibitory, non-cytotoxicsynthetic substrate.
St. James' Hosp.Mismatch location WO95/29258
Leeds, U.K.assay
Mutation location by strand pairing, addition ofmismatch-binding protein, digestion, and gelelectrophoresis.
Stanford Univ.Selective sequence EPO 682 120
Stanford, Calif.amplification
Selective amplification of target polynucleotidesequences using a promoter-containing primer.
StratageneDifficult gene hostsEPO 681 025
La Jolla, Calif.
Host organisms deficient in recombination and DNArepair; for cloning genes with superhelical structures.
SugenMegakaryocyte WO 95/29185
Redwood City, Calif.protein tyrosine kinases
Megakaryocyte protein tyrosine kinase variants; fordiagnosis and therapy.
Taisho PharmaCyclic nucleosidaseEPO 682109
Tokyo
Cyclic nucleosidase isolated from rat brain that belongs toa different isozyme family.
Tanabe, T.Prostacyclin WO 95/30013
Osaka, Japansynthase
Gene for prostacyclin synthase, encoded protein,antibodies to it; for circulatory disease treatment.
Texas, Univ. ofCombination cancer WO95/28948
Austin, Tex.therapy
Combination therapy with adenoviral vector containingp53 gene and a chemotherapeutic agent.
ToyoThermostable EPO 682 121
Osaka, Japanamplification
Thermostable enzymes for amplifying nucleic acidswithout sequential addition of further enzymes.
UnileverPlant nematode WO 95/30017
Londonresistance
Gene for protein with collagenase activity linked to aplant promoter sequence; for resistance to nematodeinfection.
UpjohnLeukocyteWO 95/29243
Kalamazoo, Mich. integrin fusion
Bacterially expressed fusion protein of leukocyte a2-integrin Mac-1 domain and glutathione-S-transferase.
UpjohnFIV vaccinesWO 95/30019
Kalamazoo, Mich.
Genes for feline immunodeficiency virus (FIV) proteinsexpressed in baculoviruses; for making vaccines.
Washington, Univ. ofThymidine kinase WO95/30007
Seattlemutants
Thymidine kinase mutants from herpes virus that showincreased biological activity.
Whitehead Inst.Mycobacterial EPO 681 026
Cambridge, Mass.vaccine vectors
Recombinant mycobacterial shuttle vectors; fortransferring genes and preparing vaccines.
Wisconsin, Univ. ofEnhanced regulator WO95/29244
Madison, Wisc.expression
Mutant genes for cell regulatory molecules that code formore stable mRNA sequences; for enhanced expression.
Wistar Inst.Wilms' tumor WO 95/29995
Philadelphiaantigen antibodies
Monoclonal antibodies against a portion of Wilms' tumorantigen; for diagnosis.
ZenecaPlant fatty acid WO 95/29246
Londonmodification
Genes for acetyl Coenzyme A carboxylase; for modifyingthe production of fatty acids in plants.
_ Compiled By Chester A. Bisbee
(c) 1997 American Health Consultants. All rights reserved.