Published Feb. 28 & March 6 (EPO); Feb. 22 & 29 (WO)
Akzo NobelContraceptive WO 96/06113
Arnhem, Netherlandsantibodies
Zona pellucida protein fragments, antibodies against these peptides;for contraception.
American CyanamidPig somatotropin WO 96/05311
Wayne, N.J.peptide
Biologically active pig somatotropin polypeptide; for enhancinganimal growth.
American CyanamidStreptococcal WO 96/05859
Wayne, N.J.vaccines
Immunogenic streptococcal polysaccharide-protein conjugates; forpreparing vaccines for immunization.
Arch Develop. Corp.Dopamine WO 96/05319
Chicagoproducing cells
Vectors with genes for dopamine biosynthetic enzymes; fortransfection of cells and increased dopamine production.
Ariad Gene TherapeuticsExpression WO 96/06111
Cambridge, Mass.obstruction
Regulated obstruction or elimination of expression of a target gene incells and organisms.
Ariad PharmaDNA-binding WO 96/06110
Cambridge, Mass.chimeras
Chimeric proteins that have at least two different DNA bindingdomains, encoding genes.
Athena NeurosciencesIntegrin-blocking WO 96/05304
S. San Franciscomolecules
Gene for integrin-blocking molecules, encoded protein; for inhibitingleukocyte adhesion and endothelial migration.
Beckman InstrumentsStreptococcus WO 96/06174
Fullerton, Calif.detection kits
Gene for Streptococcus pyrogenes DNase B; for production and usein infection detection kits.
Bio MerieuxTrypanosome WO 96/05312
Marcy-l'Etoile, Franceantigen
Trypanosoma cruzi antigen, encoding gene; for detection andtreatment of Chagas' disease.
Bio MerieuxRickettsia ribosomal WO 96/06186
Marcy-l'Etoile, FranceRNA
Ribosomal RNA fragments of Rickettsia bacteria; for identifyingspecies.
Boehringer MannheimGene therapy WO 96/05297
Mannheim, Germanyminus selection
Vectors in which the gene of interest can be separated from themarker gene; for gene therapy.
Bristol-Myers SquibbMutant cancer EPO 699 756
New Yorkantibodies
Mutant BR96 antibodies and functional equivalents that are reactivewith human carcinomas, encoding genes.
Bristol-Myers SquibbTherapeutic EPO 699 766
New Yorkantibody fusions
Fusion proteins of antibodies and a non-lymphokine cellular factor;for generating therapeutics.
Ciba-GeigyAntitumor WO 96/05298
Basel, Switzerlandantisense oligos
Antisense oligos to S-adenosylmethionine decarboxylase; for use asan antitumor agent.
Ciba-GeigyGlutamate receptorWO 96/06167
Basel, Switzerland
Gene for human glutamate receptor, encoded protein, antibodies to it,preparation methods.
Collagen CorporationMutated EPO 699 752
Palo Alto, Calif.procollagens
Mutated procollagen chains having an inserted proteolyticrecognition site, encoding genes; for tissue engineering.
Columbia Univ.Kaposi's-associated WO 96/06159
New Yorkherpes
DNA sequence that is specific to Kaposi's sarcoma-associated herpesvirus, encoded protein, antibodies; for therapy.
Connaught LabsRetroviral-like WO 96/05292
Willowdale, Ont.particles
Non-infectious retroviral-like particles that have a foreign antigeninserted; for diagnosis and making antibodies.
Connaught LabsMultiply mutated WO 96/06177
Willowdale, Ont.retroviruses
Retroviruses with multiple mutations; for creating non-infectious,retrovirus-like particles.
CytogenSynthetic genesWO 96/06188
Princeton, N.J.
Binding of ligands to random peptide libraries; for identifyingsynthetic genes for use in therapy.
Duke Univ.Male contraceptiveWO 96/05305
Durham, N.C.
Amino terminal peptide domain of sperm-specific tyrosine kinase; forcontraception.
Environmental Res. Inst.Hybridoma IL-5 WO 96/06162
TokyomRNA
Hybridoma that expresses interleukin (IL)-5 mRNA but does notmake IL-5; for drug screening.
Garvan Inst. Med. Res.Bone-specific WO 96/05299
Darlinghurst, Australiaexpression
Vector with sequences causing bone-specific expression; forscreening bone therapeutics in cells and transgenics.
Genetic TherapyResistant retroviral WO 96/04934
Gaithersburg, Md.vectors
Retroviral vectors made by producer cell lines that are resistant tolysis by serum; for gene delivery.
Gist-BrocadesMutant penicillin WO 96/05318
Delft, NetherlandsG acylases
Mutated a-lactam penicillin G acylase genes, encoded proteins,expression vectors.
Green CrossHuman serum EPO 699 687
Osaka, Japanalbumin
Recombinant human serum albumin produced by cells and purifiedby heating and chromatographic recovery.
Harvard Univ.FELV variantsEPO 699 758
Cambridge, Mass.
Feline leukemia virus (FELV) variants; for generating cell lines toproduce defective/attenuated viruses for vaccines.
Hitachi ChemicalChlamydia EPO 699 688
Tokyoantibody
Monoclonal antibody to the major outer membrane protein ofChlamydia pneumoniae; for diagnosis.
HoechstCationic drug EPO 699 753
Frankfurt, Germanytransport protein
Protein for the transport of xenobiotic and pharmaceuticalcompounds, encoding gene (in German).
Human Genome SciencesHuman CGRP WO 96/04928
Rockville, Md.receptor
Gene for human calcitonin gene related peptide (CGRP) receptor,encoded protein; for antagonist screening and therapy.
Human Genome SciencesHuman WO 96/05221
Rockville, Md.calcitonin receptor
Gene for human calcitonin receptor, encoded protein; for antagonistscreening and therapeutic development.
Human Genome SciencesHuman WO 96/05225
Rockville, Md.adrenergic receptor
Gene for human adrenergic receptor, encoded protein; for identifyingagonists and antagonists.
Human Genome SciencesHuman C5a WO 96/05226
Rockville, Md.receptor
Gene for human C5a receptor, encoded protein; for identifyingagonists and antagonists.
Human Genome SciencesHuman WO 96/05856 &
Rockville, Md.chemokines06169
Genes for human chemokines, encoded proteins; for identifyingantagonists and treating inflammation.
ImmunoEncephalitis EPO 698 665
Vienna, Austriavirus clone
Cloned tick-borne infectious encephalitis virus, its preparation; forvaccine production (in German).
ImmunogenBcl-Y apoptosis WO 96/05232
Cambridge, Mass.gene
Gene for Bcl-Y protein, encoded protein, antibodies, expressionvectors; for preventing apoptosis.
ImmunomedicsLymphoma/WO 96/04925
Morris Plains, N.J.leukemia immunoconjugates
Immunoconjugates of cytotoxic agents and humanized antibodies toB cell lymphomas and leukemias; for cancer therapy.
INSERM (Natl. Inst. Heart attack WO 96/05324
Hlth. Med. Res.)assay
Paris
In vitro detection of a predisposition for heart attacks usingcorrelated polymorphisms in angiotensin genes.
Karo BioOrphan receptorWO 96/05300
Huddinge, Sweden
Gene for OR-1, an orphan receptor belonging to the nuclear receptorfamily; encoded protein.
Kyowa Hakko KogyoMxA WO 96/05230
Tokyoantibodies
Monoclonal antibody against the human protein MxA, hybridomacell line; for viral infection diagnosis.
La Jolla Cancer Res. Fdn.Retinoblastoma WO 96/06168
La Jolla, Calif.zinc fingers
Retinoblastoma protein-interacting zinc finger proteins, encodinggenes; for modulating cell growth.
Eli LillyBK enhancer EPO 699 764
Indianapolisvectors
Eukaryotic expression vectors with the BK virus enhancer; for humanprotein C production.
Mass. Gen. Hosp.Chemotherapy WO 96/04789
Bostonsensitization
Viral vectors with cytochrome P450 gene; for transfection into braincancer cells and sensitization to chemotherapy.
Mass. Gen. Hosp.Breast cancer WO 96/05322
Bostonchloride channel
Chloride channel protein from human breast cancer cells; fordetection and diagnosis of breast cancer.
Mass. Gen. Hosp.Transplantation WO 96/06165
Bostontolerance
Pig cells genetically engineered to induce immunological tolerance;for xenograft transplantation.
Max Planck Inst.Lyme disease WO 96/05313
Heidelberg, Germanyantigen
Borrelia burgdorferi antigen OspG, encoding gene; for diagnosis andprevention of Lyme disease.
MRC (Med. Res. Counc.)Zinc finger WO 96/06166
LondonDNA libraries
DNA libraries encoding zinc finger binding domains; for display onparticles and targeting specific sequences.
Mitsubishi ChemicalHepatitis C EPO 699 751
Tokyoantisense
Antisense compounds complementary to hepatitis C virus; forinhibiting translation and use as an antiviral agent.
Molec. Immunol. Ctr.Humanized EPO 699 755
Havanaantibodies
Modified chimeric antibodies that are less immunogenic to humans,coding sequences for these antibodies.
Myriad GeneticsBRCA1 EPO 699 754; WO 96/
Salt Lake Citymutant alleles05306-05308
Isolation and detection of mutant human breast and ovarian cancerpredisposing gene alleles (BRCA1).
NIH (Natl. Inst. Hlth.)Hepatitis C WO 96/05315
Bethesda, Md.vaccine
Envelope and core hepatitis C genes, encoded peptides; for diagnosisand vaccination.
Netherlands Inst. RSV antigensWO 96/06112
Hlth. Welfare
Lelystad, Netherlands
Antigenic peptides from G protein of respiratory syncytial virus(RSV); for diagnosis and treatment of RSV infection.
Oklahoma Med. Res. Fdn.Protein WO 96/05303
Oklahoma CityC-binding protein
Gene for a transmembrane glycoprotein that binds protein C, encodedprotein; for regulating inflammation.
Pierre & Marie Curie, Univ. of HSV-1 WO 96/06176
Paristhymidine kinase
Thymidine kinase variant from type 1 herpes simplex virus (HSV-1);for blocking replication.
Rhone-Poulenc RorerAcetylcholine WO 96/05301
Antony, Francetransport protein
Gene for acetylcholine vesicular transport protein and its associatedcontrol sequences, expression vector.
Rhone-Poulenc RorerAdenoviral WO 96/05320
Antony, Franceglutathione peroxidase
Adenoviral-based vector with a gene for glutathione peroxidase; forutilization in therapy.
Rhone-Poulenc RorerRestenosis gene WO 96/05321
Antony, Francetherapy
Adenoviral-based vector with a suicide gene useful in treatingrestenosis by gene therapy.
Rockefeller Univ.Obesity geneWO 96/05309
New York
Ob gene, encoded protein, antibodies to it; for modulating bodyweight.
Sumitomo ElectricEpimorphinEPO 698 666
Osaka, Japan
Truncated and modified epimorphins, coding sequences for thesemuteins, expression vectors, production methods.
Synaptic PharmaBetaine/GABA WO 96/04790
Paramus, N.J.transporter
Gene for human betaine/GABA transporter, encoded protein, vectors;for drug screening.
TakedaG protein-coupled WO 96/05302
Osaka, Japanreceptor protein
Gene for G protein-coupled receptor protein, gene probes, encodedprotein, production methods.
TeijinTrypsin-like enzymeEPO 699 763
Osaka, Japan
Gene for a trypsin-like enzyme from the trachea of human lungs,recombinant production.
Washington Univ.Single-chain WO 96/05224
St. Louisglycoprotein hormones
Single-chain forms of glycoprotein hormones; for making agonistsand antagonists.
Washington Univ.Haemophilus WO 96/05858
St. Louisvaccines
Haemophilus adherence and penetration proteins, encoding genes,antibodies to proteins; for vaccines.
_ Compiled By Chester A. Bisbee
(c) 1997 American Health Consultants. All rights reserved.