• Advanced Life Science Holdings Inc., of Woodridge, Ill., said it increased its line of credit with Leaders Bank from $4 million to $10 million, extending the maturity date by 12 months to Jan. 1, 2011. Under terms of the agreement, ADLS will issue warrants to Leaders Bank for 65,000 shares of common stock at an exercise price of $1 per share for a five-year term.

• Cardiome Pharma Corp., of Vancouver, British Columbia, filed a shelf registration statement in connection with its obligation with a July 25, 2008, private placement of Series A preferred shares. The company intends to file a prospectus supplement to cover resales, from time to time, of the common shares issuable upon conversion of the Series A preferred shares. Cardiome focuses on developing treatments for heart and circulatory system disorders. Its stock (NASDAQ:CRME) closed at $4.50 Friday, down 23 cents.