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If it Ain’t Broke, Break it

Gene Editing Brings New Prostate Cancer Insights

By Anette Breindl
Science Editor

Friday, October 11, 2013
Most people tend to think of gene editing as a way to repair faulty genes. But a team from the University of Minnesota has gained new scientific insights into prostate cancer by taking the opposite tack. By using gene editing to introduce androgen receptor gene rearrangements that are seen in patients with castration-resistant prostate cancer into animals, they were able to show that such rearrangements drive resistance to current prostate cancer drugs because the rearranged version of the androgen receptor no longer needs to be activated by androgens.

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