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Regulatory T Cells to the Rescue

Gene Therapy Expression: No Problem from Immune System

By Brian Orelli
Contributing Writer

Monday, November 25, 2013

Adeno-associated virus (AAV)-based systems are ideally suited for delivering gene therapy. After the viral vector infects the cell, the DNA doesn’t integrate into the host genome, instead existing primarily in an episomal form, which allows for long-term expression in nonreplicating cells without DNA damage to the host cells and the risk of inducing malignancy.

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