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Heplisav Data Disappoint; Dynavax Stock Sinks 19%

By Marie Powers


Thursday, July 21, 2011
Dynavax Technologies Corp. reported Wednesday that top-line data from the Phase III trial comparing its investigational hepatitis B vaccine Heplisav met all three clinical endpoints, demonstrating noninferiority, superiority and safety in comparison to the marketed hep B vaccine Engerix-B (GlaxoSmithKline). Nevertheless, investors failed to respond with enthusiasm, perhaps reflecting nervousness about a second piece of news regarding the company's consistency analysis of manufacturing data.

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