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No Signal for Others in Class

JAK ‘Sprat’ Out by Sanofi; Safety Issue Off-Target, Analyst Says

By Randy Osborne
Staff Writer

Monday, November 18, 2013
Less than a week after Cell Therapeutics Inc. (CTI) snagged a handsome deal with Baxter International Inc. for its Janus kinase (JAK) inhibitor pacritinib – adding another industry vote for the approach – Sanofi SA disclosed safety problems with its JAK inhibitor fedratinib and ended the Phase III effort, which sparked a new look at the class.

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