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The joy of disinhibition

Ketamine discovery may yield fast-acting antidepressants

By John Fox
Staff Writer

Wednesday, March 7, 2018

HONG KONG – A Chinese study has shown for the first time that the powerful antidepressant effects of ketamine are due to blockade of rapid neuronal firing in the brain's lateral habenula (LHb) region. Such blockade was found to disinhibit reward centers and relieve depressive symptoms rapidly in animal models.

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